RS50939B - 2-fenil benzimidazoli i imidazo-/4,5/-piridini kao cdsi/chk2 -inhibitori i pomoćna sredstva u hemoterapiji ili terapiji zračenja pri lečenju kancera - Google Patents
2-fenil benzimidazoli i imidazo-/4,5/-piridini kao cdsi/chk2 -inhibitori i pomoćna sredstva u hemoterapiji ili terapiji zračenja pri lečenju kanceraInfo
- Publication number
- RS50939B RS50939B YUP-492/03A YUP49203A RS50939B RS 50939 B RS50939 B RS 50939B YU P49203 A YUP49203 A YU P49203A RS 50939 B RS50939 B RS 50939B
- Authority
- RS
- Serbia
- Prior art keywords
- pyridines
- imidazo
- chemotherapy
- adjuvants
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33030401P | 2001-10-19 | 2001-10-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU49203A YU49203A (sh) | 2006-05-25 |
| RS50939B true RS50939B (sr) | 2010-08-31 |
Family
ID=23289169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-492/03A RS50939B (sr) | 2001-10-19 | 2002-10-18 | 2-fenil benzimidazoli i imidazo-/4,5/-piridini kao cdsi/chk2 -inhibitori i pomoćna sredstva u hemoterapiji ili terapiji zračenja pri lečenju kancera |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7271261B2 (sr) |
| EP (1) | EP1435947B1 (sr) |
| JP (1) | JP4637481B2 (sr) |
| AT (1) | ATE369854T1 (sr) |
| BR (1) | BR0206161A (sr) |
| CA (1) | CA2464000C (sr) |
| DE (1) | DE60221866T2 (sr) |
| ES (1) | ES2292812T3 (sr) |
| NO (1) | NO20032759L (sr) |
| RS (1) | RS50939B (sr) |
| WO (1) | WO2003032984A1 (sr) |
| ZA (1) | ZA200305533B (sr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7884120B2 (en) | 2002-08-19 | 2011-02-08 | Lorus Therapeutics Inc. | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents |
| DE10243027A1 (de) | 2002-09-17 | 2004-03-25 | Bayer Ag | 2-Phenyl-benzimidazol-5-sulfonsäure aus isolierter 3,4-Diaminobenzol-sulfonsäure sowie deren Verwendung in kosmetischen Zubereitungen |
| WO2004093873A1 (en) | 2003-04-17 | 2004-11-04 | Janssen Pharmaceutica, N.V. | 2-phenyl-benzimidazol and 2-phenyl-imidazo-`4,5!-pyridine derivatives as checkpoint kinase cds1 (chk2) inhibitors for the treatment of cancer |
| US20050078598A1 (en) * | 2003-08-21 | 2005-04-14 | Anuj Batra | Enhancement to the multi-band OFDM physical layer |
| AU2004289539C1 (en) * | 2003-11-14 | 2012-06-07 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| US7250427B2 (en) | 2004-06-30 | 2007-07-31 | Janssen Pharmaceutica, N.V. | Aryl-substituted benzimidazole and imidazopyridine ethers |
| KR20060087386A (ko) * | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| WO2006080821A1 (en) * | 2005-01-28 | 2006-08-03 | Daewoong Pharmaceutical Co., Ltd. | Novel benzoimidazole derivatives and pharmaceutical composition comprising the same |
| MX2007011234A (es) | 2005-03-14 | 2007-11-12 | Transtech Pharma Inc | Derivados de benzazol, composiciones y metodos de uso en la forma de inhibidores de b-secretasa. |
| US8148392B2 (en) | 2005-05-25 | 2012-04-03 | Lorus Therapeutics Inc. | 2-indolyl imidazo [4,5-d] phenanthroline derivatives and their use in the treatment of cancer |
| CA2612419C (en) | 2005-06-23 | 2017-06-13 | Array Biopharma Inc. | Process for preparing benzimidazole compounds |
| WO2007070173A2 (en) * | 2005-10-31 | 2007-06-21 | Merck & Co., Inc. | Cetp inhibitors |
| PL2054405T3 (pl) | 2006-07-11 | 2014-03-31 | Dae Woong Pharma | Nowe pochodne biarylobenzimidazolu i zawierająca je kompozycja farmaceutyczna |
| FR2904314A1 (fr) * | 2006-07-26 | 2008-02-01 | Centre Nat Rech Scient | Composes pyridaziniques et pyrroliques lineaires, procedes d'obtention et applications |
| PE20080888A1 (es) * | 2006-10-18 | 2008-08-26 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1) |
| UA100684C2 (uk) | 2007-03-15 | 2013-01-25 | Новартіс Аг | Похідні бензилу та піридинілу як модулятори сигнального шляху hedgehog |
| MX2010001866A (es) * | 2007-08-23 | 2010-03-11 | Sanofi Aventis | Derivados de azoloarina, metodo para su produccion, productos farmaceuticos que contienen estos compuestos y su uso. |
| GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| AU2008335880B2 (en) * | 2007-12-13 | 2014-03-13 | Siena Biotech S.P.A. | Hedgehog pathway antagonists and therapeutic applications thereof |
| JP2009171854A (ja) * | 2008-01-21 | 2009-08-06 | Olympus Corp | 細胞洗浄方法および移植物の製造方法 |
| GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US20110021532A1 (en) * | 2008-04-22 | 2011-01-27 | Merck Frosst Canada Ltd. | Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| EP2424533A4 (en) | 2009-04-27 | 2012-10-17 | High Point Pharmaceuticals Llc | SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE AS-SECRETASE INHIBITORS |
| JP2013522364A (ja) | 2010-03-23 | 2013-06-13 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 置換イミダゾ［１，２−ｂ］ピリダジン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用の方法 |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US9273347B2 (en) * | 2010-09-10 | 2016-03-01 | Bio-Rad Laboratories, Inc. | Detection of RNA-interacting regions in DNA |
| JP5695749B2 (ja) * | 2010-09-28 | 2015-04-08 | デーウン ファーマシューティカル カンパニー リミテッド | ベンゾイミダゾール誘導体の新規な製造方法 |
| WO2012112606A1 (en) | 2011-02-15 | 2012-08-23 | Bio-Rad Laboratories, Inc. | Detecting methylati0n in a subpopulation of genomic dna |
| KR101387970B1 (ko) | 2011-04-20 | 2014-04-25 | 인제대학교 산학협력단 | 암 예방 및 치료용 조성물 및 건강기능식품 |
| JP6073910B2 (ja) | 2011-11-09 | 2017-02-01 | キャンサー・リサーチ・テクノロジー・リミテッド | ５−（ピリジン−２−イル−アミノ）−ピラジン−２−カルボニトリル化合物及びその治療使用 |
| SG11201407238VA (en) | 2012-05-15 | 2014-12-30 | Cancer Rec Tech Ltd | 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof |
| AU2014235962A1 (en) | 2013-03-20 | 2015-09-10 | Aptose Biosciences Inc. | 2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer |
| CN103288803B (zh) * | 2013-05-17 | 2017-10-31 | 郎恒元 | 苯并咪唑酰胺类化合物及其制备方法和应用 |
| WO2015051302A1 (en) | 2013-10-04 | 2015-04-09 | Aptose Biosciences Inc. | Compositions and methods for treating cancers |
| CN104194778B (zh) * | 2014-09-25 | 2016-03-30 | 黑龙江大学 | 磷氧基团修饰n-苯基-苯并咪唑电子传输材料、合成方法及电致磷光器件的制备方法 |
| JP7278945B2 (ja) * | 2016-09-20 | 2023-05-22 | サントル レオン ベラール | 抗癌剤としてのベンゾイミダゾール誘導体 |
| WO2019089511A1 (en) | 2017-10-30 | 2019-05-09 | Aptose Biosciences Inc. | Aryl imidazoles for the treatment of cancer |
| EA202192394A1 (ru) * | 2019-04-10 | 2022-01-24 | Селлестия Биотек Аг | Ингибиторы пути передачи сигнала notch и их применение для лечения рака |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346575A1 (de) | 1983-12-23 | 1985-07-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| LU85544A1 (fr) | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
| DE3522230A1 (de) | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| GB9108279D0 (en) * | 1991-04-18 | 1991-06-05 | Ucb Sa | A method of preparing 1h-benzimidazoles |
| US5821258A (en) | 1994-12-27 | 1998-10-13 | Mitsui Chemicals, Inc. | Phenylbenzimidazole derivatives |
| US6184235B1 (en) | 1996-08-14 | 2001-02-06 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as MCP-1 antagonists |
| US5942532A (en) | 1997-09-05 | 1999-08-24 | Ortho Pharmaceutical Corporation | 2-substituted phenyl-benzimidazole antibacterial agents |
| AU747705C (en) * | 1997-12-13 | 2004-09-23 | Bristol-Myers Squibb Company | Use of pyrazolo (3,4-b) pyridine as cyclin dependent kinase inhibitors |
| CA2332989A1 (en) | 1998-05-22 | 1999-12-02 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of ige |
| ATE284392T1 (de) | 1998-11-03 | 2004-12-15 | Abbott Gmbh & Co Kg | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| GB9914825D0 (en) * | 1999-06-24 | 1999-08-25 | Smithkline Beecham Spa | Novel compounds |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| GB0007934D0 (en) * | 2000-03-31 | 2000-05-17 | Darwin Discovery Ltd | Chemical compounds |
| DE10026435A1 (de) * | 2000-05-29 | 2002-04-18 | Osram Opto Semiconductors Gmbh | Kalzium-Magnesium-Chlorosilikat-Leuchtstoff und seine Anwendung bei Lumineszenz-Konversions-LED |
| JP4695819B2 (ja) * | 2000-05-29 | 2011-06-08 | パテント−トロイハント−ゲゼルシヤフト フユール エレクトリツシエ グリユーラムペン ミツト ベシユレンクテル ハフツング | Ｌｅｄをベースとする白色発光照明ユニット |
| ATE350468T1 (de) | 2000-06-21 | 2007-01-15 | Chugai Pharmaceutical Co Ltd | Cds1-knockout-mäusen und davon abgeleitete zelllinien |
| US7311858B2 (en) * | 2004-08-04 | 2007-12-25 | Intematix Corporation | Silicate-based yellow-green phosphors |
| US20060027785A1 (en) * | 2004-08-04 | 2006-02-09 | Intematix Corporation | Novel silicate-based yellow-green phosphors |
| US20060279196A1 (en) * | 2005-06-02 | 2006-12-14 | Wei-Jen Hsu | White LED |
| JP2007231250A (ja) * | 2006-02-02 | 2007-09-13 | Nichia Chem Ind Ltd | 蛍光体及びそれを用いた発光装置 |
-
2002
- 2002-10-18 AT AT02770620T patent/ATE369854T1/de not_active IP Right Cessation
- 2002-10-18 US US10/273,487 patent/US7271261B2/en not_active Expired - Lifetime
- 2002-10-18 DE DE60221866T patent/DE60221866T2/de not_active Expired - Lifetime
- 2002-10-18 JP JP2003535787A patent/JP4637481B2/ja not_active Expired - Lifetime
- 2002-10-18 RS YUP-492/03A patent/RS50939B/sr unknown
- 2002-10-18 EP EP02770620A patent/EP1435947B1/en not_active Expired - Lifetime
- 2002-10-18 ES ES02770620T patent/ES2292812T3/es not_active Expired - Lifetime
- 2002-10-18 WO PCT/US2002/033371 patent/WO2003032984A1/en active IP Right Grant
- 2002-10-18 CA CA2464000A patent/CA2464000C/en not_active Expired - Lifetime
- 2002-10-18 BR BR0206161-9A patent/BR0206161A/pt not_active Application Discontinuation
-
2003
- 2003-06-17 NO NO20032759A patent/NO20032759L/no unknown
- 2003-07-17 ZA ZA200305533A patent/ZA200305533B/en unknown
-
2007
- 2007-08-02 US US11/832,789 patent/US7504414B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE369854T1 (de) | 2007-09-15 |
| YU49203A (sh) | 2006-05-25 |
| DE60221866D1 (de) | 2007-09-27 |
| DE60221866T2 (de) | 2008-05-29 |
| US7271261B2 (en) | 2007-09-18 |
| ES2292812T3 (es) | 2008-03-16 |
| US20080009493A1 (en) | 2008-01-10 |
| WO2003032984A8 (en) | 2003-11-20 |
| BR0206161A (pt) | 2005-02-01 |
| ZA200305533B (en) | 2004-10-18 |
| EP1435947B1 (en) | 2007-08-15 |
| WO2003032984A1 (en) | 2003-04-24 |
| JP2005506349A (ja) | 2005-03-03 |
| NO20032759L (no) | 2003-08-18 |
| EP1435947A1 (en) | 2004-07-14 |
| CA2464000A1 (en) | 2003-04-24 |
| US20030176438A1 (en) | 2003-09-18 |
| CA2464000C (en) | 2011-04-19 |
| NO20032759D0 (no) | 2003-06-17 |
| JP4637481B2 (ja) | 2011-02-23 |
| US7504414B2 (en) | 2009-03-17 |
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