ATE549311T1 - Amino-propanolderivative als modulatoren des sphingosin-1-phosphat-rezeptors - Google Patents

Amino-propanolderivative als modulatoren des sphingosin-1-phosphat-rezeptors

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Publication number
ATE549311T1
ATE549311T1 AT04739810T AT04739810T ATE549311T1 AT E549311 T1 ATE549311 T1 AT E549311T1 AT 04739810 T AT04739810 T AT 04739810T AT 04739810 T AT04739810 T AT 04739810T AT E549311 T1 ATE549311 T1 AT E549311T1
Authority
AT
Austria
Prior art keywords
amino
sphingosine
modulators
phosphate receptor
propanol derivatives
Prior art date
Application number
AT04739810T
Other languages
English (en)
Inventor
Claus Ehrhardt
Klaus Hinterding
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE549311T1 publication Critical patent/ATE549311T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Surgery (AREA)
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AT04739810T 2003-06-12 2004-06-11 Amino-propanolderivative als modulatoren des sphingosin-1-phosphat-rezeptors ATE549311T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0313612.4A GB0313612D0 (en) 2003-06-12 2003-06-12 Organic compounds
PCT/EP2004/006318 WO2004110979A2 (en) 2003-06-12 2004-06-11 Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator

Publications (1)

Publication Number Publication Date
ATE549311T1 true ATE549311T1 (de) 2012-03-15

Family

ID=27589973

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04739810T ATE549311T1 (de) 2003-06-12 2004-06-11 Amino-propanolderivative als modulatoren des sphingosin-1-phosphat-rezeptors

Country Status (12)

Country Link
US (1) US7696184B2 (de)
EP (1) EP1636171B1 (de)
JP (1) JP4512592B2 (de)
CN (1) CN100358861C (de)
AT (1) ATE549311T1 (de)
AU (1) AU2004247384B2 (de)
BR (1) BRPI0411294A (de)
CA (1) CA2527977A1 (de)
ES (1) ES2384324T3 (de)
GB (1) GB0313612D0 (de)
MX (1) MXPA05013348A (de)
WO (1) WO2004110979A2 (de)

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GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
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ES2369520T3 (es) 2005-12-15 2011-12-01 Mitsubishi Tanabe Pharma Corporation Compuesto amínico y su uso para propósitos médicos.
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
US8273748B2 (en) 2006-08-08 2012-09-25 Kyorin Pharmaceutical Co., Ltd. Amino alcohol derivative and immunosuppresive agent having same as an active ingredient
RU2430925C2 (ru) 2006-08-08 2011-10-10 Киорин Фармасьютикал Ко., Лтд. Производное аминофосфата и модулятор рецептора s1p, содержащий его в качестве активного ингредиента
BRPI0813683A2 (pt) * 2007-06-14 2019-09-24 Mitsubishi Tanabe Pharma Corp composto amina e uso farmacêutico do mesmo
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
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BRPI0917923B1 (pt) 2008-08-27 2022-04-05 Arena Pharmaceuticals Inc Derivado de ácido tricíclico substituído, sua composição, seu uso e processo para preparar a referida composição
MY160127A (en) 2009-06-22 2017-02-28 Ampio Pharmaceuticals Inc Method for treatment of diseases
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EP2542554B1 (de) 2010-03-03 2015-11-04 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von s1p1-rezeptormodulatoren und kristallinen formen davon
CN102565253A (zh) * 2010-12-16 2012-07-11 中国人民解放军第二军医大学 一种小分子代谢物图谱及其制作方法和用途
US8895753B2 (en) * 2011-12-23 2014-11-25 Meiji Seika Pharma Co., Ltd. S1P receptor modulating agent
AU2013361338A1 (en) 2012-12-19 2015-08-06 Ampio Pharmaceuticals, Inc. Method for treatment of diseases
WO2016112075A1 (en) 2015-01-06 2016-07-14 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
AU2016284162A1 (en) 2015-06-22 2018-02-01 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(Compound1) for use in SIP1 receptor-associated disorders
CA3053416A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
EP3847158A1 (de) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Verbindungen zur verwendung bei der behandlung von autoimmun- und entzündlichen erkrankungen

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JP4512592B2 (ja) 2010-07-28
US7696184B2 (en) 2010-04-13
JP2006527231A (ja) 2006-11-30
MXPA05013348A (es) 2006-03-09
CN1798728A (zh) 2006-07-05
CN100358861C (zh) 2008-01-02
WO2004110979A2 (en) 2004-12-23
AU2004247384B2 (en) 2008-02-28
EP1636171A2 (de) 2006-03-22
EP1636171B1 (de) 2012-03-14
AU2004247384A1 (en) 2004-12-23
CA2527977A1 (en) 2004-12-23
WO2004110979A3 (en) 2005-02-10
ES2384324T3 (es) 2012-07-03
BRPI0411294A (pt) 2006-08-29
US20070010494A1 (en) 2007-01-11
GB0313612D0 (en) 2003-07-16

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