ATE382615T1 - Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung - Google Patents
Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendungInfo
- Publication number
- ATE382615T1 ATE382615T1 AT01909008T AT01909008T ATE382615T1 AT E382615 T1 ATE382615 T1 AT E382615T1 AT 01909008 T AT01909008 T AT 01909008T AT 01909008 T AT01909008 T AT 01909008T AT E382615 T1 ATE382615 T1 AT E382615T1
- Authority
- AT
- Austria
- Prior art keywords
- chromes
- tocotrienols
- tocopherols
- side chain
- chain derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/502,592 US6770672B1 (en) | 1998-09-23 | 2000-02-11 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE382615T1 true ATE382615T1 (de) | 2008-01-15 |
Family
ID=23998504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01909008T ATE382615T1 (de) | 2000-02-11 | 2001-02-09 | Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung |
Country Status (14)
Country | Link |
---|---|
US (2) | US7312232B2 (de) |
EP (1) | EP1254130B1 (de) |
JP (1) | JP2004504268A (de) |
KR (1) | KR100847678B1 (de) |
CN (1) | CN1243000C (de) |
AT (1) | ATE382615T1 (de) |
AU (2) | AU2001236805B2 (de) |
CA (1) | CA2399802C (de) |
DE (1) | DE60132171D1 (de) |
IL (2) | IL151108A0 (de) |
NZ (1) | NZ520798A (de) |
RU (1) | RU2263672C2 (de) |
WO (1) | WO2001058889A1 (de) |
ZA (1) | ZA200206243B (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
RU2263672C2 (ru) | 2000-02-11 | 2005-11-10 | Рисерч Дивелопмент Фаундейшн | Токоферолы, токотриенолы, другие хроманы и производные по боковым цепям и их применение |
AUPR549901A0 (en) * | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
CN1262274C (zh) * | 2000-11-14 | 2006-07-05 | 生命健康科学有限公司 | 磷酸盐衍生物复合物 |
CA2453823C (en) * | 2001-07-27 | 2010-12-21 | Vital Health Sciences Pty Ltd | Dermal therapy using phosphate derivatives of electron transfer agents |
CN1604772A (zh) * | 2001-12-13 | 2005-04-06 | 生命健康科学有限公司 | 化合物的透皮转运 |
US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
CA2513427C (en) * | 2003-01-17 | 2012-03-27 | Vital Health Sciences Pty Ltd. | Compounds having anti-proliferative properties |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
GB0313612D0 (en) | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
EP1664067A2 (de) * | 2003-09-15 | 2006-06-07 | DSM IP Assets B.V. | NEUE ROUTE ZU alpha-TOCOPHEROL, alpha-TOCOPHERYLALKANOATEN UND VORSTUFEN DAVON |
JP4847437B2 (ja) | 2004-03-03 | 2011-12-28 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | アルカロイド製剤 |
KR20070108382A (ko) * | 2005-03-03 | 2007-11-09 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | 항암성 화합물 |
MX2007015949A (es) | 2005-06-17 | 2008-03-07 | Vital Health Sciences Pty Ltd | Un vehiculo que comprende uno o mas derivados de fosfato de di- y/o mono-(agentes de transferencia de electrones) o complejos de los mismos. |
EP1973547A1 (de) * | 2005-12-23 | 2008-10-01 | Vital Health Sciences Pty Ltd. | Verbindungen mit zytokin-modulierenden eigenschaften |
JP5256049B2 (ja) * | 2006-02-21 | 2013-08-07 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | 抗癌剤 |
ES2414205T3 (es) | 2006-06-02 | 2013-07-18 | The Ohio State University Research Foundation | Agentes terapéuticos para el tratamiento de linfoma de células del manto |
US8288369B2 (en) * | 2006-06-27 | 2012-10-16 | University Of South Florida | Delta-tocotrienol treatment and prevention of pancreatic cancer |
US20100292316A1 (en) * | 2007-07-18 | 2010-11-18 | Research Development Foundation | Improved therapeutic methods and compositions comprising chroman ring compounds |
NZ602579A (en) | 2008-03-14 | 2013-12-20 | Stephen John Ralph | Mitochondrially delivered anti-cancer compounds |
EP2419414A4 (de) * | 2009-04-13 | 2013-12-04 | Univ Ohio State Res Found | Mittel zur aktivierung der protein-phosphatase 2a |
WO2010121111A1 (en) | 2009-04-17 | 2010-10-21 | The Ohio State University Research Foundation | Antiadhesion agents |
AU2011213557B2 (en) | 2010-02-05 | 2015-05-07 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
CA2794734C (en) | 2010-03-30 | 2017-12-12 | Phosphagenics Limited | Transdermal delivery patch |
US8309768B2 (en) | 2010-11-29 | 2012-11-13 | The Ohio State University Research Foundation | FTY720-derived anticancer agents |
EP2685992A4 (de) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | Aminochinoline als kinasehemmer |
CN104470358A (zh) * | 2012-05-18 | 2015-03-25 | 俄亥俄州立大学 | 用于改善肝功能的方法 |
CA2875975A1 (en) | 2012-06-06 | 2013-12-12 | Unither Virology, Llc | Novel iminosugars and their applications |
IN2014KN02893A (de) * | 2012-06-13 | 2015-05-08 | Cytec Tech Corp | |
AU2014318014C1 (en) * | 2013-09-06 | 2018-11-15 | Research Development Foundation | Alpha-tea salt forms: compositions and uses for treating disease |
MX2016003215A (es) | 2013-09-13 | 2016-11-25 | Univ Arkansas | Preparacion y uso de una composicion para la prevencion y mitigacion de los efectos de la radiacion. |
US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
CN105078963B (zh) * | 2015-09-29 | 2018-06-22 | 中山大学 | α-生育酚在制备治疗血吸虫病药物中的应用 |
CA3007587C (en) | 2015-12-09 | 2023-12-05 | Phosphagenics Limited | Pharmaceutical formulation |
BR112019012946A2 (pt) | 2016-12-21 | 2019-11-26 | Avecho Biotechnology Ltd | processo |
KR20180002728U (ko) | 2017-03-10 | 2018-09-19 | 주식회사 두울온돌침대 | 전열 매트리스 |
CA3135920A1 (en) * | 2020-10-28 | 2022-04-28 | Hermay Labs Corporation | SILENT LABLE AND COHERENT REDOX ANALOGS FOR VITAMIN E ENRICHMENT |
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CA2220541A1 (en) | 1997-11-07 | 1999-05-07 | Mcgill University | Analogs of vitamin e |
US5917060A (en) * | 1997-12-17 | 1999-06-29 | Basf Aktiengesellschaft | Preparation of chromanyl derivatives |
US6770672B1 (en) | 1998-09-23 | 2004-08-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
WO2000016772A1 (en) * | 1998-09-23 | 2000-03-30 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
FR2784988B1 (fr) * | 1998-10-23 | 2002-09-20 | Adir | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5990322A (en) | 1999-03-09 | 1999-11-23 | Sk Corporation | Alpha-tocopherol cyclopropylates, the new vitamin E derivatives and method for producing the same |
US6127382A (en) | 1999-08-16 | 2000-10-03 | Allergan Sales, Inc. | Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
RU2263672C2 (ru) | 2000-02-11 | 2005-11-10 | Рисерч Дивелопмент Фаундейшн | Токоферолы, токотриенолы, другие хроманы и производные по боковым цепям и их применение |
US20030236301A1 (en) | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
EP1520014A4 (de) * | 2002-04-19 | 2006-01-25 | Res Dev Foundation | Mit tocopherol assoziiertes protein und verwendungen davon |
-
2001
- 2001-02-09 RU RU2002124135/04A patent/RU2263672C2/ru not_active IP Right Cessation
- 2001-02-09 AU AU2001236805A patent/AU2001236805B2/en not_active Ceased
- 2001-02-09 DE DE60132171T patent/DE60132171D1/de not_active Expired - Lifetime
- 2001-02-09 JP JP2001558439A patent/JP2004504268A/ja not_active Ceased
- 2001-02-09 CA CA002399802A patent/CA2399802C/en not_active Expired - Fee Related
- 2001-02-09 AU AU3680501A patent/AU3680501A/xx active Pending
- 2001-02-09 EP EP01909008A patent/EP1254130B1/de not_active Expired - Lifetime
- 2001-02-09 AT AT01909008T patent/ATE382615T1/de not_active IP Right Cessation
- 2001-02-09 IL IL15110801A patent/IL151108A0/xx active IP Right Grant
- 2001-02-09 CN CNB018075363A patent/CN1243000C/zh not_active Expired - Fee Related
- 2001-02-09 WO PCT/US2001/004168 patent/WO2001058889A1/en active IP Right Grant
- 2001-02-09 NZ NZ520798A patent/NZ520798A/en not_active IP Right Cessation
- 2001-02-09 KR KR1020027010387A patent/KR100847678B1/ko not_active IP Right Cessation
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2002
- 2002-08-06 IL IL151108A patent/IL151108A/en not_active IP Right Cessation
- 2002-08-06 ZA ZA200206243A patent/ZA200206243B/xx unknown
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2003
- 2003-08-20 US US10/644,418 patent/US7312232B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
CA2399802C (en) | 2009-12-08 |
DE60132171D1 (de) | 2008-02-14 |
IL151108A0 (en) | 2003-04-10 |
NZ520798A (en) | 2004-05-28 |
IL151108A (en) | 2006-08-01 |
RU2002124135A (ru) | 2004-01-10 |
EP1254130B1 (de) | 2008-01-02 |
CA2399802A1 (en) | 2001-08-16 |
RU2263672C2 (ru) | 2005-11-10 |
EP1254130A4 (de) | 2003-04-23 |
JP2004504268A (ja) | 2004-02-12 |
CN1243000C (zh) | 2006-02-22 |
US20080119514A1 (en) | 2008-05-22 |
WO2001058889A1 (en) | 2001-08-16 |
AU2001236805B2 (en) | 2005-07-14 |
AU3680501A (en) | 2001-08-20 |
US7608638B2 (en) | 2009-10-27 |
US20040235938A1 (en) | 2004-11-25 |
US7312232B2 (en) | 2007-12-25 |
KR100847678B1 (ko) | 2008-07-23 |
ZA200206243B (en) | 2009-10-28 |
CN1529701A (zh) | 2004-09-15 |
KR20030005186A (ko) | 2003-01-17 |
EP1254130A1 (de) | 2002-11-06 |
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