IT1256264B - N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione - Google Patents

N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione

Info

Publication number
IT1256264B
IT1256264B ITMI922997A ITMI922997A IT1256264B IT 1256264 B IT1256264 B IT 1256264B IT MI922997 A ITMI922997 A IT MI922997A IT MI922997 A ITMI922997 A IT MI922997A IT 1256264 B IT1256264 B IT 1256264B
Authority
IT
Italy
Prior art keywords
acil
hydroxyamine
peroxidation
phenomena
inflammation
Prior art date
Application number
ITMI922997A
Other languages
English (en)
Inventor
Valle Francesco Della
Silvana Lorenzi
Gabriele Marcolongo
Original Assignee
Lifegroup Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifegroup Spa filed Critical Lifegroup Spa
Publication of ITMI922997A0 publication Critical patent/ITMI922997A0/it
Priority to ITMI922997A priority Critical patent/IT1256264B/it
Priority to JP5350273A priority patent/JPH06234756A/ja
Priority to DK93121046T priority patent/DK0604995T3/da
Priority to DE69321332T priority patent/DE69321332T2/de
Priority to US08/175,233 priority patent/US5480645A/en
Priority to ES93121046T priority patent/ES2124765T3/es
Priority to AT93121046T priority patent/ATE171703T1/de
Priority to EP93121046A priority patent/EP0604995B1/en
Priority to CA002112611A priority patent/CA2112611A1/en
Publication of ITMI922997A1 publication Critical patent/ITMI922997A1/it
Application granted granted Critical
Publication of IT1256264B publication Critical patent/IT1256264B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

N-acilderivati di idrossiammine con acidi carbossilici di derivati del benzocromano o del 2,3-diidro-benzofurano e relative composizioni farmaceutiche atte al trattamento terapeutico di quelle patologie del SNC, vascolari, cardiovascolari e dermatologiche ed oftalmiche in cui, accanto ad un effetto antiossidante sia importante avere un effetto di modulazione del processo infiammatorio.
ITMI922997A 1992-12-31 1992-12-31 N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione IT1256264B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITMI922997A IT1256264B (it) 1992-12-31 1992-12-31 N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione
JP5350273A JPH06234756A (ja) 1992-12-31 1993-12-28 スカベンジャー活性を有し、かつ過酸化および炎症症状を伴う急性および慢性病状に有用なヒドロキシアミンｎ−アシル誘導体
US08/175,233 US5480645A (en) 1992-12-31 1993-12-29 Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
DE69321332T DE69321332T2 (de) 1992-12-31 1993-12-29 Hydroxyamin-N-acyl-Derivate mit Radikalfängeraktivität und nützlich in akuten und chronischen Erkrankungen die mit Peroxidations- und Entzündungserscheinungen einhergehen
DK93121046T DK0604995T3 (da) 1992-12-31 1993-12-29 Hydroxyamin-N-acylderivater, som har radikalfjernende aktivitet og kan anvendes ved akutte og kroniske patologier forbundet
ES93121046T ES2124765T3 (es) 1992-12-31 1993-12-29 N-acil derivados de hidroxiaminas que tienen actividad eliminadora y que son utiles en patologias agudas y cronicas asociadas con los fenomenos de peroxidacion e inflamacion.
AT93121046T ATE171703T1 (de) 1992-12-31 1993-12-29 Hydroxyamin-n-acyl-derivate mit radikalfängeraktivität und nützlich in akuten und chronischen erkrankungen die mit peroxidations- und entzündungserscheinungen einhergehen
EP93121046A EP0604995B1 (en) 1992-12-31 1993-12-29 Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
CA002112611A CA2112611A1 (en) 1992-12-31 1993-12-30 Hydroxyamines n-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922997A IT1256264B (it) 1992-12-31 1992-12-31 N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione

Publications (3)

Publication Number Publication Date
ITMI922997A0 ITMI922997A0 (it) 1992-12-31
ITMI922997A1 ITMI922997A1 (it) 1994-07-01
IT1256264B true IT1256264B (it) 1995-11-29

Family

ID=11364566

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922997A IT1256264B (it) 1992-12-31 1992-12-31 N-acilderivati di idrossiammine dotati di attivita' scavenger ed utilizzabili nelle patologie acute e croniche correlate a fenomeni di perossidazione ed infiammazione

Country Status (9)

Country Link
US (1) US5480645A (it)
EP (1) EP0604995B1 (it)
JP (1) JPH06234756A (it)
AT (1) ATE171703T1 (it)
CA (1) CA2112611A1 (it)
DE (1) DE69321332T2 (it)
DK (1) DK0604995T3 (it)
ES (1) ES2124765T3 (it)
IT (1) IT1256264B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017953A (en) * 1993-12-28 2000-01-25 Allergan Sales, Inc. Thromboxane ligands
ES2217392T3 (es) * 1996-02-02 2004-11-01 MERCK & CO., INC. Agentes antidiabeticos.
US5859051A (en) * 1996-02-02 1999-01-12 Merck & Co., Inc. Antidiabetic agents
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6703384B2 (en) 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
WO2000046183A1 (en) 1999-02-08 2000-08-10 Checkpoint Genetics, Inc. N-substituted amino acids, antioxidant pharmaceutical compositions containing same and methods using same
IL151108A0 (en) * 2000-02-11 2003-04-10 Res Dev Foundation Tocopherols, tocotrienols, other chroman and chain derivatives and uses thereof
US6299865B1 (en) * 2000-05-02 2001-10-09 Peter Styczynski Reduction of hair growth
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
CA2542795A1 (en) * 2003-10-15 2005-04-28 Matsushita Electric Industrial Co., Ltd. Systems and methods for assessing neuronal degeneration
FR2875803B1 (fr) * 2004-09-24 2006-11-24 Catalys Sarl Preparation de composes phenol-amides a proprietes antioxydantes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5594382A (en) * 1979-01-11 1980-07-17 Eisai Co Ltd Chroman-based compound and cholestrol lowering drug comprising it
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
JPH02215778A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd ３，４―ジヒドロ―２ｈ―ベンゾピラン誘導体及びその医薬用途
IT1231341B (it) * 1989-08-18 1991-11-28 Foscama Biomed Chim Farma 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche.
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE158287T1 (de) * 1992-04-06 1997-10-15 Merrell Pharma Inc Derivate von 2,3-dihydro-2,2,4,6,7-pentaalkyl-5- benzofuranen

Also Published As

Publication number Publication date
DE69321332D1 (de) 1998-11-05
EP0604995B1 (en) 1998-09-30
US5480645A (en) 1996-01-02
CA2112611A1 (en) 1994-07-01
ITMI922997A0 (it) 1992-12-31
ITMI922997A1 (it) 1994-07-01
ES2124765T3 (es) 1999-02-16
ATE171703T1 (de) 1998-10-15
JPH06234756A (ja) 1994-08-23
EP0604995A1 (en) 1994-07-06
DE69321332T2 (de) 1999-04-22
DK0604995T3 (da) 1999-06-21

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