JPS5594382A - Chroman-based compound and cholestrol lowering drug comprising it - Google Patents
Chroman-based compound and cholestrol lowering drug comprising itInfo
- Publication number
- JPS5594382A JPS5594382A JP98879A JP98879A JPS5594382A JP S5594382 A JPS5594382 A JP S5594382A JP 98879 A JP98879 A JP 98879A JP 98879 A JP98879 A JP 98879A JP S5594382 A JPS5594382 A JP S5594382A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- cholestrol
- compound
- lowering drug
- chroman
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound shown by the formula I (R1, R2, and R3 are H or methyl; R4 is phenyl substituted lower alkyl or hydrooxysubstituted lower alkyl; A is -CO-, -CH2O-; B is -NH-, -O-, -CONH-, etc.). EXAMPLE:2- ( N,N-Dimethylamino ) -ethyl-2- ( 2,2,5,7,8-pentamethyl-6-chromanyloxy)-isobutylate. USE:A cholestrol lowering drug capable of improving the defect of the side action of digestive organs. PROCESS:A carboxylic acid shown by the formula II or its reactive is derivative reacted with an alcohol or amino compound shown by the formula H-B-R4 (B is -O-, -NH-, forms morpholino together with R4) to give a compound shown by the formula I where A is -CO- and B is -O- or -NH-. The clinical dose of the compound of this invention is 200-2000mg/day and the compound is administered twice or three times daily.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP98879A JPS5594382A (en) | 1979-01-11 | 1979-01-11 | Chroman-based compound and cholestrol lowering drug comprising it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP98879A JPS5594382A (en) | 1979-01-11 | 1979-01-11 | Chroman-based compound and cholestrol lowering drug comprising it |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP27907085A Division JPS61143372A (en) | 1985-12-13 | 1985-12-13 | Chroman compound and cholesterol-lowering agent containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5594382A true JPS5594382A (en) | 1980-07-17 |
JPS6123796B2 JPS6123796B2 (en) | 1986-06-07 |
Family
ID=11488971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP98879A Granted JPS5594382A (en) | 1979-01-11 | 1979-01-11 | Chroman-based compound and cholestrol lowering drug comprising it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5594382A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4681890A (en) * | 1984-10-30 | 1987-07-21 | Kuraray Co., Ltd. | 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same |
EP0183869B1 (en) * | 1984-12-06 | 1991-04-17 | Kuraray Co., Ltd. | Chroman compounds and their use |
EP0604995A1 (en) * | 1992-12-31 | 1994-07-06 | LIFEGROUP S.p.A. | Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena |
-
1979
- 1979-01-11 JP JP98879A patent/JPS5594382A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4681890A (en) * | 1984-10-30 | 1987-07-21 | Kuraray Co., Ltd. | 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same |
EP0183869B1 (en) * | 1984-12-06 | 1991-04-17 | Kuraray Co., Ltd. | Chroman compounds and their use |
EP0604995A1 (en) * | 1992-12-31 | 1994-07-06 | LIFEGROUP S.p.A. | Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena |
US5480645A (en) * | 1992-12-31 | 1996-01-02 | Lifegroup S.P.A. | Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena |
Also Published As
Publication number | Publication date |
---|---|
JPS6123796B2 (en) | 1986-06-07 |
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