JPS5594382A - Chroman-based compound and cholestrol lowering drug comprising it - Google Patents

Chroman-based compound and cholestrol lowering drug comprising it

Info

Publication number
JPS5594382A
JPS5594382A JP98879A JP98879A JPS5594382A JP S5594382 A JPS5594382 A JP S5594382A JP 98879 A JP98879 A JP 98879A JP 98879 A JP98879 A JP 98879A JP S5594382 A JPS5594382 A JP S5594382A
Authority
JP
Japan
Prior art keywords
formula
cholestrol
compound
lowering drug
chroman
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP98879A
Other languages
Japanese (ja)
Other versions
JPS6123796B2 (en
Inventor
Norio Minami
Shizumasa Kijima
Keiichi Nomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP98879A priority Critical patent/JPS5594382A/en
Publication of JPS5594382A publication Critical patent/JPS5594382A/en
Publication of JPS6123796B2 publication Critical patent/JPS6123796B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formula I (R1, R2, and R3 are H or methyl; R4 is phenyl substituted lower alkyl or hydrooxysubstituted lower alkyl; A is -CO-, -CH2O-; B is -NH-, -O-, -CONH-, etc.). EXAMPLE:2- ( N,N-Dimethylamino ) -ethyl-2- ( 2,2,5,7,8-pentamethyl-6-chromanyloxy)-isobutylate. USE:A cholestrol lowering drug capable of improving the defect of the side action of digestive organs. PROCESS:A carboxylic acid shown by the formula II or its reactive is derivative reacted with an alcohol or amino compound shown by the formula H-B-R4 (B is -O-, -NH-, forms morpholino together with R4) to give a compound shown by the formula I where A is -CO- and B is -O- or -NH-. The clinical dose of the compound of this invention is 200-2000mg/day and the compound is administered twice or three times daily.
JP98879A 1979-01-11 1979-01-11 Chroman-based compound and cholestrol lowering drug comprising it Granted JPS5594382A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP98879A JPS5594382A (en) 1979-01-11 1979-01-11 Chroman-based compound and cholestrol lowering drug comprising it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP98879A JPS5594382A (en) 1979-01-11 1979-01-11 Chroman-based compound and cholestrol lowering drug comprising it

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP27907085A Division JPS61143372A (en) 1985-12-13 1985-12-13 Chroman compound and cholesterol-lowering agent containing same

Publications (2)

Publication Number Publication Date
JPS5594382A true JPS5594382A (en) 1980-07-17
JPS6123796B2 JPS6123796B2 (en) 1986-06-07

Family

ID=11488971

Family Applications (1)

Application Number Title Priority Date Filing Date
JP98879A Granted JPS5594382A (en) 1979-01-11 1979-01-11 Chroman-based compound and cholestrol lowering drug comprising it

Country Status (1)

Country Link
JP (1) JPS5594382A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681890A (en) * 1984-10-30 1987-07-21 Kuraray Co., Ltd. 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
EP0183869B1 (en) * 1984-12-06 1991-04-17 Kuraray Co., Ltd. Chroman compounds and their use
EP0604995A1 (en) * 1992-12-31 1994-07-06 LIFEGROUP S.p.A. Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681890A (en) * 1984-10-30 1987-07-21 Kuraray Co., Ltd. 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
EP0183869B1 (en) * 1984-12-06 1991-04-17 Kuraray Co., Ltd. Chroman compounds and their use
EP0604995A1 (en) * 1992-12-31 1994-07-06 LIFEGROUP S.p.A. Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena
US5480645A (en) * 1992-12-31 1996-01-02 Lifegroup S.P.A. Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena

Also Published As

Publication number Publication date
JPS6123796B2 (en) 1986-06-07

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