SK283869B6 - Tricyklické triazolobenzazepínové deriváty, spôsob ich prípravy a antialergické prostriedky - Google Patents

Tricyklické triazolobenzazepínové deriváty, spôsob ich prípravy a antialergické prostriedky Download PDF

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Publication number
SK283869B6
SK283869B6 SK425-2000A SK4252000A SK283869B6 SK 283869 B6 SK283869 B6 SK 283869B6 SK 4252000 A SK4252000 A SK 4252000A SK 283869 B6 SK283869 B6 SK 283869B6
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SK
Slovakia
Prior art keywords
compound
formula
alkyl
substituted
alkoxy
Prior art date
Application number
SK425-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK4252000A3 (en
Inventor
Yasuo Ohtsuka
Toshio Nishizuka
Sohjiro Shiokawa
Seiji Tsutsumi
Mami Kawaguchi
Hideo Kitagawa
Hiromi Takata
Takashi Shishikura
Toyoaki Ishikura
Kenichi Fushihara
Yumiko Okada
Sachiko Miyamoto
Maki Shiobara
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Publication of SK4252000A3 publication Critical patent/SK4252000A3/sk
Publication of SK283869B6 publication Critical patent/SK283869B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK425-2000A 1997-09-29 1998-09-29 Tricyklické triazolobenzazepínové deriváty, spôsob ich prípravy a antialergické prostriedky SK283869B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26461197 1997-09-29
JP5206398 1998-03-04
PCT/JP1998/004363 WO1999016770A1 (fr) 1997-09-29 1998-09-29 Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique

Publications (2)

Publication Number Publication Date
SK4252000A3 SK4252000A3 (en) 2000-10-09
SK283869B6 true SK283869B6 (sk) 2004-03-02

Family

ID=26392670

Family Applications (1)

Application Number Title Priority Date Filing Date
SK425-2000A SK283869B6 (sk) 1997-09-29 1998-09-29 Tricyklické triazolobenzazepínové deriváty, spôsob ich prípravy a antialergické prostriedky

Country Status (25)

Country Link
US (3) US6372735B1 (pt)
EP (1) EP1026167B1 (pt)
JP (1) JP3188482B2 (pt)
KR (1) KR100389140B1 (pt)
CN (2) CN1155599C (pt)
AT (1) ATE233764T1 (pt)
AU (1) AU744636B2 (pt)
BR (1) BR9814055B1 (pt)
CA (1) CA2305307C (pt)
DE (1) DE69811930T2 (pt)
DK (1) DK1026167T3 (pt)
ES (1) ES2191963T3 (pt)
HK (1) HK1032782A1 (pt)
HU (1) HUP0004020A3 (pt)
ID (1) ID24101A (pt)
IL (1) IL135303A0 (pt)
NO (2) NO319542B1 (pt)
NZ (1) NZ503601A (pt)
PL (1) PL339544A1 (pt)
PT (1) PT1026167E (pt)
RU (1) RU2198885C2 (pt)
SK (1) SK283869B6 (pt)
TR (1) TR200000808T2 (pt)
TW (1) TW510902B (pt)
WO (1) WO1999016770A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055886A1 (fr) * 2001-12-26 2003-07-10 Meiji Seika Kaisha, Ltd. Substance amorphe d'un derive de triazolobenzazepine tricyclique
ATE359277T1 (de) * 2002-02-01 2007-05-15 Meiji Seika Kaisha Verfahren zur herstellung einer 1,2,3- triazolverbindung
KR101120337B1 (ko) 2002-07-09 2012-02-29 브리스톨-마이어스 스큅 컴퍼니 항당뇨제 및 항비만제로서 유용한 치환된 헤테로시클릭유도체 및 방법
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004113343A1 (ja) * 2003-06-19 2004-12-29 Meiji Seika Kaisha, Ltd. 三環性トリアゾロベンゾアゼピン誘導体の新規結晶性物質
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
RS50568B8 (sr) 2004-05-14 2019-08-30 Millennium Pharm Inc Jedinjenja i postupci za inhibiciju mitotičke progresije inhibiranjem aurora kinaze
MX2008011178A (es) * 2006-03-02 2008-09-25 Meiji Seika Kaisha Agente profilàctico o terapèutico para enfermedad oftàlmica alèrgica o enfermedad nasal alèrgica, que comprende derivado tricìclico de triazolobenzacepina.
JP5588172B2 (ja) * 2006-09-25 2014-09-10 フォルシュングフェアブント ベルリン エー.ファウ. プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CA2709119C (en) * 2007-12-18 2013-08-06 Meiji Seika Kaisha, Ltd. Preventive or therapeutic agent for inflammatory bowel diseases
AU2009330727B2 (en) 2008-12-22 2016-07-28 Millennium Pharmaceuticals, Inc. Combination of Aurora kinase inhibitors and anti-CD20 antibodies
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
US9107911B2 (en) 2010-01-07 2015-08-18 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
US8653064B2 (en) 2010-02-19 2014-02-18 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-D][2]benzazepin-2-yl]amino}-2-methoxybenzoate
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3290664B2 (ja) * 1993-12-28 2002-06-10 明治製菓株式会社 3環性ベンゾアゼピンおよびベンゾチアゼピン誘導体
US6093714A (en) * 1995-06-15 2000-07-25 Meiji Seika Kaisha, Ltd. Tricyclic benzazepine compounds
KR19990087585A (ko) * 1996-03-08 1999-12-27 돈 리사 로얄 신경학적 활성제로서의 아졸로벤즈아제핀 유도체
US20070059533A1 (en) * 2005-09-12 2007-03-15 Burdette Steven R Thermal reflow of glass and fused silica body

Also Published As

Publication number Publication date
NZ503601A (en) 2002-02-01
CN1523019A (zh) 2004-08-25
AU9186998A (en) 1999-04-23
JP3188482B2 (ja) 2001-07-16
NO20043765L (no) 2000-05-18
NO20001500D0 (no) 2000-03-23
DK1026167T3 (da) 2003-05-26
BR9814055A (pt) 2000-09-26
US7238812B2 (en) 2007-07-03
TR200000808T2 (tr) 2000-08-21
KR100389140B1 (ko) 2003-06-25
NO319542B1 (no) 2005-08-29
US7022860B2 (en) 2006-04-04
NO20001500L (no) 2000-05-18
DE69811930D1 (de) 2003-04-10
PL339544A1 (en) 2000-12-18
CA2305307A1 (en) 1999-04-08
DE69811930T2 (de) 2003-12-18
US20020137739A1 (en) 2002-09-26
SK4252000A3 (en) 2000-10-09
HK1032782A1 (en) 2002-08-30
ID24101A (id) 2000-07-06
BR9814055B1 (pt) 2009-05-05
HUP0004020A2 (hu) 2001-09-28
EP1026167A4 (en) 2001-07-11
KR20010030784A (ko) 2001-04-16
CA2305307C (en) 2004-11-30
RU2198885C2 (ru) 2003-02-20
CN1155599C (zh) 2004-06-30
CN1312135C (zh) 2007-04-25
IL135303A0 (en) 2001-05-20
ES2191963T3 (es) 2003-09-16
US20060074074A1 (en) 2006-04-06
EP1026167B1 (en) 2003-03-05
HUP0004020A3 (en) 2002-12-28
WO1999016770A1 (fr) 1999-04-08
PT1026167E (pt) 2003-07-31
ATE233764T1 (de) 2003-03-15
AU744636B2 (en) 2002-02-28
CN1278262A (zh) 2000-12-27
US6372735B1 (en) 2002-04-16
EP1026167A1 (en) 2000-08-09
TW510902B (en) 2002-11-21

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