NO20060206L - Nye azetidinforbindelser - Google Patents
Nye azetidinforbindelserInfo
- Publication number
- NO20060206L NO20060206L NO20060206A NO20060206A NO20060206L NO 20060206 L NO20060206 L NO 20060206L NO 20060206 A NO20060206 A NO 20060206A NO 20060206 A NO20060206 A NO 20060206A NO 20060206 L NO20060206 L NO 20060206L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- thiophen
- benzo
- alkynyl
- cycloalkyl
- Prior art date
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P13/00—Drugs for disorders of the urinary system
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/76—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Foreliggende oppfinnelse angår en forbindelse med den generelle formel (I) hvor Het er en eventuelt substituert 4-, 5-, 6- eller 7-leddet heterocyklisk ring som har minst et nitrogenatom; RI er hydrogen, hydroksy, C1-C4 alkyl, C3-C4 cykloalkyl, C2-C4 alkenyl eller C2-C4 alkynyl; R2 og R3 er uavhengig av hverandre valgt fra hydrogen, C1-C4 alkyl, C3-C4 cykloalkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoksy, halogen og cyano, forutsatt at R2 og R3 ikke begge er hydrogen; R4 er C1-C4 alkyl, C3-C4 cykloalkyl, C2-C4 alkenyl eller C2-C4 alkynyl; Ar er et eventuelt substituert, aromatisk ringsystem valgt frapyridinyl; 1-naftyl; 5,6,7,8-tetrahydro-l-naftyl; quinolinyl; 2,3-dihydro-l,4-benzodioksinyl; 1,3-benzodioksolyl; 5,6,7,8-tetrahydroquinolinyl; 5,6,7,8-tetrahydroisoquinolinyl; 5,6,7,8-tetrahydroquinazolin-4-yl; l-benzo[b]tiofen-7-yl; 1-benzo[b]tiofen-4-yl; l-benzo[b]tiofen-3-yl; isoquinolinyl; quinazolinyl; og indan-4-yl; eller Ar er substituert fenyl; eller en enantiomer derav eller hvilket som helst salt derav; et farmasøytisk preparat som inneholder de nevnte forbindelser eller anvendelsen av de nevnte forbindelser i terapi. Foreliggende oppfinnelse angår videre fremgangsmåter for fremstilling av forbindelser med formel I og nye mellomprodukter som anvendes ved fremstilling av disse.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301744A SE0301744D0 (sv) | 2003-06-13 | 2003-06-13 | New compounds |
SE0303493A SE0303493D0 (sv) | 2003-12-19 | 2003-12-19 | New compounds |
PCT/SE2004/000901 WO2004110344A2 (en) | 2003-06-13 | 2004-06-09 | New azetidine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20060206L true NO20060206L (no) | 2006-03-13 |
NO332109B1 NO332109B1 (no) | 2012-06-25 |
Family
ID=33554614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060206A NO332109B1 (no) | 2003-06-13 | 2006-01-13 | Nye azetidinforbindelser, fremgangsmate for fremstilling derav og mellomprodukter, anvendelse derav, samt farmasoytiske formuleringer med slike forbindelser |
Country Status (24)
Country | Link |
---|---|
US (1) | US7402581B2 (no) |
EP (1) | EP1636221B1 (no) |
JP (1) | JP4982886B2 (no) |
KR (1) | KR20060021373A (no) |
AR (1) | AR044662A1 (no) |
AT (1) | ATE439358T1 (no) |
AU (1) | AU2004246983B2 (no) |
BR (1) | BRPI0411285A (no) |
CA (1) | CA2529126C (no) |
CO (1) | CO5640122A2 (no) |
DE (1) | DE602004022546D1 (no) |
DK (1) | DK1636221T3 (no) |
ES (1) | ES2330522T3 (no) |
HK (1) | HK1088004A1 (no) |
IL (1) | IL171894A (no) |
IS (1) | IS8228A (no) |
MX (1) | MXPA05013276A (no) |
MY (1) | MY146599A (no) |
NO (1) | NO332109B1 (no) |
PL (1) | PL1636221T3 (no) |
PT (1) | PT1636221E (no) |
RU (1) | RU2356888C2 (no) |
TW (1) | TW200508221A (no) |
WO (1) | WO2004110344A2 (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0403005D0 (sv) * | 2004-12-09 | 2004-12-09 | Astrazeneca Ab | New use |
CN101203511A (zh) * | 2005-06-23 | 2008-06-18 | 阿斯利康(瑞典)有限公司 | 作为神经激肽受体拮抗剂用于治疗胃肠疾病的新氮杂环丁烷衍生物 |
CN101208327A (zh) * | 2005-06-23 | 2008-06-25 | 阿斯利康(瑞典)有限公司 | 作为神经激肽受体拮抗剂用于治疗胃肠疾病的新氮杂环丁烷衍生物 |
AR057828A1 (es) * | 2005-09-29 | 2007-12-19 | Astrazeneca Ab | Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica |
AR056087A1 (es) * | 2005-09-29 | 2007-09-19 | Astrazeneca Ab | Derivados de azetidina como antagonistas de receptores de neuroquina nk |
WO2007043939A1 (en) * | 2005-10-07 | 2007-04-19 | Astrazeneca Ab | Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a |
WO2007043938A1 (en) * | 2005-10-07 | 2007-04-19 | Astrazeneca Ab | NOVEL CRYSTALLINE FORM OF 3,5-DIBROMO-N- [ (2S) -2- (-4- FLUOROPHENYL) -4- (3-MORPHOLIN-4-YLAZTIDIN-l-YL) BUTYL] -N METHYLBENZAMIDE, MODIFICATION B |
WO2007136325A1 (en) * | 2006-05-18 | 2007-11-29 | Astrazeneca Ab | 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 2 |
WO2007136326A2 (en) * | 2006-05-18 | 2007-11-29 | Astrazeneca Ab | ) t e text as een esta s e y t s ut o ty to rea as o ows: 1- [ (4- [benzoyl (methyl) amino] -3- (phenyl) butyl] azetidine derivatives for the treatment of gastrointestinal disorders 3 |
US8106208B2 (en) * | 2006-05-18 | 2012-01-31 | Albireo Ab | Benzamide compounds that act as NK receptor antagonists |
CL2007002097A1 (es) * | 2006-07-20 | 2008-01-18 | Smithkline Beecham Corp | Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras. |
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GB9601202D0 (en) * | 1996-01-22 | 1996-03-20 | Pfizer Ltd | Piperidones |
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GB9922519D0 (en) * | 1998-10-07 | 1999-11-24 | Zeneca Ltd | Compounds |
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GB9924141D0 (en) | 1998-10-30 | 1999-12-15 | Zeneca Ltd | Treatment of gastric asthma |
GB9826941D0 (en) | 1998-12-09 | 1999-02-03 | Zeneca Pharmaceuticals | Compounds |
SE0004827D0 (sv) | 2000-12-22 | 2000-12-22 | Astrazeneca Ab | Therapeutic compounds |
SE0103795D0 (sv) | 2001-11-02 | 2001-11-02 | Astrazeneca Ab | Compounds and method for the treatment of överactive bladder |
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- 2004-06-09 US US10/560,319 patent/US7402581B2/en not_active Expired - Fee Related
- 2004-06-09 DK DK04736475T patent/DK1636221T3/da active
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- 2004-06-09 WO PCT/SE2004/000901 patent/WO2004110344A2/en active Application Filing
- 2004-06-09 AU AU2004246983A patent/AU2004246983B2/en not_active Ceased
- 2004-06-09 RU RU2005136535/04A patent/RU2356888C2/ru not_active IP Right Cessation
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- 2004-06-09 AT AT04736475T patent/ATE439358T1/de not_active IP Right Cessation
- 2004-06-09 KR KR1020057023907A patent/KR20060021373A/ko not_active Application Discontinuation
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- 2004-06-09 PT PT04736475T patent/PT1636221E/pt unknown
- 2004-06-09 BR BRPI0411285-7A patent/BRPI0411285A/pt active Search and Examination
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EP1636221A2 (en) | 2006-03-22 |
JP2006527267A (ja) | 2006-11-30 |
WO2004110344A2 (en) | 2004-12-23 |
IL171894A0 (en) | 2006-04-10 |
AR044662A1 (es) | 2005-09-21 |
ATE439358T1 (de) | 2009-08-15 |
CA2529126C (en) | 2011-11-08 |
JP4982886B2 (ja) | 2012-07-25 |
EP1636221B1 (en) | 2009-08-12 |
PT1636221E (pt) | 2009-11-05 |
HK1088004A1 (en) | 2006-10-27 |
MXPA05013276A (es) | 2006-03-09 |
DE602004022546D1 (de) | 2009-09-24 |
RU2005136535A (ru) | 2006-07-27 |
CO5640122A2 (es) | 2006-05-31 |
TW200508221A (en) | 2005-03-01 |
AU2004246983A1 (en) | 2004-12-23 |
US7402581B2 (en) | 2008-07-22 |
CA2529126A1 (en) | 2004-12-23 |
PL1636221T3 (pl) | 2010-01-29 |
KR20060021373A (ko) | 2006-03-07 |
RU2356888C2 (ru) | 2009-05-27 |
NO332109B1 (no) | 2012-06-25 |
US20060172988A1 (en) | 2006-08-03 |
MY146599A (en) | 2012-08-30 |
AU2004246983B2 (en) | 2008-06-12 |
ES2330522T3 (es) | 2009-12-11 |
BRPI0411285A (pt) | 2006-08-01 |
WO2004110344A3 (en) | 2005-02-17 |
DK1636221T3 (da) | 2009-10-12 |
IS8228A (is) | 2006-01-11 |
IL171894A (en) | 2012-05-31 |
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