DE60324685D1 - 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren - Google Patents

2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren

Info

Publication number
DE60324685D1
DE60324685D1 DE60324685T DE60324685T DE60324685D1 DE 60324685 D1 DE60324685 D1 DE 60324685D1 DE 60324685 T DE60324685 T DE 60324685T DE 60324685 T DE60324685 T DE 60324685T DE 60324685 D1 DE60324685 D1 DE 60324685D1
Authority
DE
Germany
Prior art keywords
sub
phenylthiomethyl
selective norepinephrine
morpholin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60324685T
Other languages
English (en)
Inventor
Basingstoke Walter
Basingstoke Clark
Peter Thaddeus Gallagher
Basingstoke Haughton
Basingstoke Rudyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0219690A external-priority patent/GB0219690D0/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE60324685D1 publication Critical patent/DE60324685D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
DE60324685T 2002-08-23 2003-08-18 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren Expired - Fee Related DE60324685D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0219690A GB0219690D0 (en) 2002-08-23 2002-08-23 Benzyl morpholine derivatives
US41532802P 2002-10-01 2002-10-01
PCT/US2003/023269 WO2004017977A2 (en) 2002-08-23 2003-08-18 2- (phenoxymethyl)- and 2- (phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors

Publications (1)

Publication Number Publication Date
DE60324685D1 true DE60324685D1 (de) 2008-12-24

Family

ID=31948037

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324685T Expired - Fee Related DE60324685D1 (de) 2002-08-23 2003-08-18 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren

Country Status (7)

Country Link
US (1) US7384941B2 (de)
EP (1) EP1534291B1 (de)
AT (1) ATE413882T1 (de)
AU (1) AU2003269923A1 (de)
DE (1) DE60324685D1 (de)
ES (1) ES2315525T3 (de)
WO (1) WO2004017977A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002367147A1 (en) 2001-12-27 2003-07-15 Daiichi Pharmaceutical Co., Ltd. Beta-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
ATE327982T1 (de) 2002-08-23 2006-06-15 Lilly Co Eli Benzylmorpholinderivate
CA2526487A1 (en) * 2003-06-30 2005-01-06 Daiichi Pharmaceutical Co., Ltd. Heterocyclic methyl sulfone derivative
GB0319793D0 (en) * 2003-08-22 2003-09-24 Lilly Co Eli Pyridinylmorpholine derivatives
JP2007513945A (ja) * 2003-12-12 2007-05-31 イーライ リリー アンド カンパニー 体熱感、衝動調節障害および一般的な病状による人格変化の治療
ATE423772T1 (de) * 2003-12-23 2009-03-15 Lilly Co Eli Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
EP1745029A1 (de) * 2004-04-30 2007-01-24 Warner-Lambert Company LLC Substituierte morpholinverbindungen zur behandlung von erkrankungen des zentralen nervensystems
WO2007005935A2 (en) * 2005-07-06 2007-01-11 Molecular Neuroimaging, Llc Norepinephrine transporter radiotracers and methods of syntheses thereof
JP5405571B2 (ja) 2008-07-24 2014-02-05 セラヴァンス， インコーポレーテッド ３−（フェノキシフェニルメチル）ピロリジン化合物
DK2358674T3 (da) 2008-11-14 2013-04-08 Theravance Inc Fremgangsmåde til fremstilling af 4-[2-(2-fluorphenoxymethyl)phenyl]piperidinforbindelser
JP2012524098A (ja) * 2009-04-15 2012-10-11 セラヴァンス， インコーポレーテッド ３−（フェノキシピロリジン−３−イル−メチル）ヘテロアリール、３−（フェニルピロリジン−３−イルメトキシ）ヘテロアリールおよび３−（ヘテロアリールピロリジン−３−イルメトキシ）ヘテロアリール化合物
CN102471258A (zh) * 2009-07-13 2012-05-23 施万制药 3-苯氧基甲基吡咯烷化合物
WO2011011231A1 (en) 2009-07-21 2011-01-27 Theravance, Inc. 3-phenoxymethylpyrrolidine compounds
JP5705239B2 (ja) 2010-01-11 2015-04-22 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー セロトニンおよびノルエピネフリン再取込みインヒビターとしての１−（２−フェノキシメチルフェニル）ピペラジン化合物
US8530663B2 (en) * 2010-03-22 2013-09-10 Theravance, Inc. 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
ES2533434T3 (es) 2010-10-11 2015-04-10 Theravance Biopharma R&D Ip, Llc Inhibidores de la captación de la serotonina
WO2012075239A1 (en) 2010-12-03 2012-06-07 Theravance, Inc. Serotonin reuptake inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759013R (fr) 1969-11-17 1971-05-17 Ici Ltd Derives de la
GB1412546A (en) 1973-08-08 1975-11-05 Ici Ltd Morpholine derivatives
GB2167407B (en) 1984-11-22 1988-05-11 Erba Farmitalia Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof
US5658590A (en) 1995-01-11 1997-08-19 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
CZ16798A3 (cs) 1995-07-24 1998-11-11 Eli Lilly And Company Použití duloxetinu pro léčbu poruch pozornosti /hyperaktivity a farmaceutický prostředek s jeho obsahem
JP2001517628A (ja) 1997-09-23 2001-10-09 イーライ・リリー・アンド・カンパニー 注意欠陥／多動障害の治療法
US6274579B1 (en) 1998-01-21 2001-08-14 Glaxo Wellcome Inc. Pharmaceutically active morpholinol
GB9812662D0 (en) 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
US6503905B1 (en) 1998-12-29 2003-01-07 Pfizer Inc 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
AP2001002252A0 (en) 1999-02-23 2001-09-30 Pfizer Prod Inc Monoamine reuptake inhibitors for treatment of CNS disorders.
AU771258B2 (en) 1999-07-01 2004-03-18 Pharmacia & Upjohn Company Highly selective norepinephrine reuptake inhibitors and methods of using the same

Also Published As

Publication number Publication date
US20060035894A1 (en) 2006-02-16
AU2003269923A8 (en) 2004-03-11
US7384941B2 (en) 2008-06-10
WO2004017977A2 (en) 2004-03-04
AU2003269923A1 (en) 2004-03-11
EP1534291A2 (de) 2005-06-01
WO2004017977A3 (en) 2004-04-01
ES2315525T3 (es) 2009-04-01
ATE413882T1 (de) 2008-11-15
EP1534291B1 (de) 2008-11-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee