ATE413882T1 - 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren - Google Patents

2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren

Info

Publication number
ATE413882T1
ATE413882T1 AT03751812T AT03751812T ATE413882T1 AT E413882 T1 ATE413882 T1 AT E413882T1 AT 03751812 T AT03751812 T AT 03751812T AT 03751812 T AT03751812 T AT 03751812T AT E413882 T1 ATE413882 T1 AT E413882T1
Authority
AT
Austria
Prior art keywords
sub
inhibitors
reuppose
phenylthiomethyl
morpholine derivatives
Prior art date
Application number
AT03751812T
Other languages
English (en)
Inventor
Magnus Wilhelm Walter
Barry Peter Clark
Peter Thaddeus Gallagher
Helen Louise Haughton
Helene C E Rudyk
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0219690A external-priority patent/GB0219690D0/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE413882T1 publication Critical patent/ATE413882T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT03751812T 2002-08-23 2003-08-18 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren ATE413882T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0219690A GB0219690D0 (en) 2002-08-23 2002-08-23 Benzyl morpholine derivatives
US41532802P 2002-10-01 2002-10-01

Publications (1)

Publication Number Publication Date
ATE413882T1 true ATE413882T1 (de) 2008-11-15

Family

ID=31948037

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03751812T ATE413882T1 (de) 2002-08-23 2003-08-18 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren

Country Status (7)

Country Link
US (1) US7384941B2 (de)
EP (1) EP1534291B1 (de)
AT (1) ATE413882T1 (de)
AU (1) AU2003269923A1 (de)
DE (1) DE60324685D1 (de)
ES (1) ES2315525T3 (de)
WO (1) WO2004017977A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2304140C2 (ru) 2001-12-27 2007-08-10 Дайити Фармасьютикал Ко., Лтд. ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА
ES2264028T3 (es) 2002-08-23 2006-12-16 Eli Lilly And Company Derivados de bencilmorfolina.
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
CA2526487A1 (en) * 2003-06-30 2005-01-06 Daiichi Pharmaceutical Co., Ltd. Heterocyclic methyl sulfone derivative
GB0319793D0 (en) * 2003-08-22 2003-09-24 Lilly Co Eli Pyridinylmorpholine derivatives
CA2548304A1 (en) * 2003-12-12 2005-07-07 Eli Lilly And Company Selective norepinephrine reuptake inhibitors for the treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
DE602004019698D1 (de) * 2003-12-23 2009-04-09 Lilly Co Eli Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds
WO2005105763A1 (en) 2004-04-30 2005-11-10 Warner-Lambert Company Llc Substituted morpholine compounds for the treatment of central nervous system disorders
WO2007005935A2 (en) * 2005-07-06 2007-01-11 Molecular Neuroimaging, Llc Norepinephrine transporter radiotracers and methods of syntheses thereof
TWI438190B (zh) * 2008-07-24 2014-05-21 Theravance Inc ３－（苯氧基苯基甲基）吡咯啶化合物
DK2358675T3 (da) 2008-11-14 2013-01-14 Theravance Inc 4-[2-(2-Fluorphenoxymethyl)phenyl]piperidinforbindelser
US20100267743A1 (en) * 2009-04-15 2010-10-21 Stangeland Eric L 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
CA2767372A1 (en) * 2009-07-13 2011-01-20 Theravance, Inc. 3-phenoxymethylpyrrolidine compounds
ES2495366T3 (es) 2009-07-21 2014-09-17 Theravance, Inc. Compuestos de 3-fenoximetilpirrolidina
EP2523945A1 (de) 2010-01-11 2012-11-21 Theravance, Inc. 1-(2-phenoxymethylphenyl-)piperazinverbindungen als serotonin- und norepinephrin-wiederaufnahmehemmer
WO2011119461A1 (en) * 2010-03-22 2011-09-29 Theravance, Inc. 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
CA2811641A1 (en) 2010-10-11 2012-04-19 Theravance, Inc. Serotonin reuptake inhibitors
US8501964B2 (en) 2010-12-03 2013-08-06 Theravance, Inc. Serotonin reuptake inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759013R (fr) 1969-11-17 1971-05-17 Ici Ltd Derives de la
GB1412546A (en) 1973-08-08 1975-11-05 Ici Ltd Morpholine derivatives
GB2167407B (en) * 1984-11-22 1988-05-11 Erba Farmitalia Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof
US5658590A (en) 1995-01-11 1997-08-19 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
CA2227410A1 (en) 1995-07-24 1997-02-06 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
AU9214498A (en) 1997-09-23 1999-04-12 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
ATE365042T1 (de) 1998-01-21 2007-07-15 Glaxo Group Ltd Verwendung von morpholinol zur behandlung von sexuellen funktionsstörungen
GB9812662D0 (en) 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
US6503905B1 (en) 1998-12-29 2003-01-07 Pfizer Inc 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
CN1157365C (zh) 1999-02-23 2004-07-14 辉瑞产品公司 治疗cns疾病的一元胺摄取抑制剂
PT1459751E (pt) 1999-07-01 2005-11-30 Pharmacia & Upjohn Co Llc (s,s)-reboxetina para tratar as enxaquecas

Also Published As

Publication number Publication date
ES2315525T3 (es) 2009-04-01
AU2003269923A8 (en) 2004-03-11
EP1534291A2 (de) 2005-06-01
US7384941B2 (en) 2008-06-10
WO2004017977A3 (en) 2004-04-01
US20060035894A1 (en) 2006-02-16
DE60324685D1 (de) 2008-12-24
AU2003269923A1 (en) 2004-03-11
EP1534291B1 (de) 2008-11-12
WO2004017977A2 (en) 2004-03-04

Similar Documents

Publication Publication Date Title
ATE413882T1 (de) 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren
BRPI0413232A (pt) novos compostos tendo atividade inibitória contra os trasnportadores dependentes de sódio
MXPA04001258A (es) Activador para el receptor d que responde al proliferador de peroxisoma.
ATE377004T1 (de) Proteinkinaseinhibitoren
DE60331187D1 (de) Kinaseinhibitoren
EP1642880A4 (de) Proteininhibitoren der hsp90-familie
EA200401172A1 (ru) Производные n-[фенил(пиперидин-2-ил)метил]бензамида, способ их получения и их применение в терапии
HRP20000406B1 (en) Arylpiperazines having activity at the serotonin 1a receptor
PH12015501098A1 (en) Antituberculous composition comprising oxazole compounds
NO20015446D0 (no) Kinolin-derivater som inhibitorer for MEK-enzymer
DE602004020730D1 (de) Pharmazeutisches verfahren und damit hergestellte verbindungen
ATE374750T1 (de) Serotoninwiederaufnahme-inhibitoren
HUP0302961A2 (hu) (Aminoalkoxibenzoil) benzofuránok vagy benzotiofének, eljárás ilyen vegyületek előállítására és ilyen vegyületeket tartalmazó készítmények
EA200800149A1 (ru) 4,5-диарилпиррольные производные, способ их получения и применение в терапии
NO971687D0 (no) Diazepinoindoler som forsfodiesterase IV-inhibitorer
EA200101230A1 (ru) Новые ингибиторы металлопротеаз, метод их получения и содержащие их фармацевтические композиции
ATE343566T1 (de) Propanamine derivate als serotonin und norepinephrin reuptake-inhibitoren
ATE239722T1 (de) Benzofurylpiperazine als serotonin-agonisten
DK1628968T3 (da) 4-imidazolin-2-on-forbindelser
EA200200523A1 (ru) Новые разветвленные замещенные аминопроизводные 3-амино-1-фенил-1h[1,2,4]триазола, способы их получения и содержащие их фармацевтические композиции
EA200101050A1 (ru) Замещенные бензолактамные соединения
ATE497497T1 (de) 1,2,4-triazolderivat, verfahren zu dessenherstellung, und dieses enthaltende pharmazeutische zusammensetzung
ATE327982T1 (de) Benzylmorpholinderivate
DK1433480T3 (da) Lægemiddel indeholdende pyrimidin-derivat

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties