ES2185185T3 - Nuevos compuestos espiroazabiciclicos heterociclicos. - Google Patents
Nuevos compuestos espiroazabiciclicos heterociclicos.Info
- Publication number
- ES2185185T3 ES2185185T3 ES98934078T ES98934078T ES2185185T3 ES 2185185 T3 ES2185185 T3 ES 2185185T3 ES 98934078 T ES98934078 T ES 98934078T ES 98934078 T ES98934078 T ES 98934078T ES 2185185 T3 ES2185185 T3 ES 2185185T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Un compuesto de fórmula (I) en la que n es 0 ó 1; m es 0 ó 1; p es 0 ó 1; X es oxígeno o azufre; Y es CH, N o NO; W es oxígeno, H{sub,2} o F; A es N o C{(}R{sup,2}{; G es N o C{(}R{sup,3}{; D es N o C{(}R{sup,4}{; con la condición de que no más de uno de A, G y D sea nitrógeno, pero al menos uno de Y, A, G y D sea nitrógeno o NO; R{sup,1} es hidrógeno o alquilo C{sub,1} a C{sub,4}; R{sup,2}, R{sup,3}, y R{sup,4} son independientemente hidrógeno, halógeno, alquilo C{sub,1}-C{sub,4}, alquenilo C{sub,2}-C{sub,4}, alquinilo, arilo, heteroarilo C{sub,2}-C{sub,4}, OH, alquilo OC{sub,1}-C{sub,4}, CO{sub,2}R{sup,1}, -CN, -NO{sub,2}, -NR{sup,5} R{sup,6}, -CF{sub,3}, -OSO{sub,2}CF{sub,3} o R{sup,2} y R{sup,3}, o R{sup,3} y R{sup,4}, respectivamente, pueden formar al mismo tiempo otro anillo de seis elementos aromático o heteroaromático compartiendo A y G, o G y D, respectivamente, conteniendo entre cero y dos átomos de nitrógeno, y sustituido con uno a dos de los sustituyentes siguientes: independientemente hidrógeno, halógeno, alquilo C{sub,1}-C{sub,4}, alquenilo C{sub,2}-C{sub,4}, alquinilo, arilo, heteroarilo C{sub,2}-C{sub,4}, OH, alquilo OC{sub,1}-C{sub,4}, CO{sub,2}R{sup,1}, -CN, -NO{sub,2}, -NR{sup,5} R{sup,6}, -CF{sub,3}, -OSO{sub,2}CF{sub,3}; R{sup,5} y R{sup,6} son independientemente hidrógeno, alquilo C{sub,1}-C{sub,4}, C{(}O { R{sup,7}, C{(}O { NHR{sup,8}, C{(}O { OR{sup,9}, SO{sub,2}R{sup,10} o puede al mismo tiempo ser {(}CH{sub,2}{{sub,j}Q{(}CH{sub,2}{{sub,k} donde Q es O, S, NR{sup,11}, o un enlace; j es de 2 a 7, k es de 0 a 2; R{sup,7}, R{sup,8}, R{sup,9}, R{sup,10} y R{sup,11} son independientemente alquilo, arilo o heteroarilo C{sub,1}-C{sub,4}, o uno de sus enantiómeros, y sus sales farmacéuticamente aceptables, procedimientos para prepararlos, composiciones conteniéndolos, y su uso en terapia, especialmente en el tratamiento o profilaxis de enfermedades psicóticas y enfermedades de deterioro intelectual.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702746A SE9702746D0 (sv) | 1997-07-18 | 1997-07-18 | New compounds |
SE9800977A SE9800977D0 (sv) | 1998-03-24 | 1998-03-24 | New compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2185185T3 true ES2185185T3 (es) | 2003-04-16 |
Family
ID=26663041
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02005982T Expired - Lifetime ES2231599T3 (es) | 1997-07-18 | 1998-07-10 | Spiro [1-azabicyclo[2.2.2]octane-3,2'(3'h)-furo[2,3-b]pyridine for use in the treatment of psychotic and intellectual impairment disorders. |
ES98934078T Expired - Lifetime ES2185185T3 (es) | 1997-07-18 | 1998-07-10 | Nuevos compuestos espiroazabiciclicos heterociclicos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02005982T Expired - Lifetime ES2231599T3 (es) | 1997-07-18 | 1998-07-10 | Spiro [1-azabicyclo[2.2.2]octane-3,2'(3'h)-furo[2,3-b]pyridine for use in the treatment of psychotic and intellectual impairment disorders. |
Country Status (31)
Country | Link |
---|---|
US (6) | US6110914A (es) |
EP (2) | EP0996622B1 (es) |
JP (1) | JP2001510194A (es) |
KR (1) | KR100560036B1 (es) |
CN (1) | CN1117755C (es) |
AR (2) | AR013184A1 (es) |
AT (2) | ATE283859T1 (es) |
AU (1) | AU739022B2 (es) |
BR (1) | BR9810924A (es) |
CA (1) | CA2296031C (es) |
DE (2) | DE69827977T2 (es) |
DK (1) | DK0996622T3 (es) |
EE (1) | EE04399B1 (es) |
ES (2) | ES2231599T3 (es) |
HK (3) | HK1025322A1 (es) |
HU (1) | HUP0003844A3 (es) |
ID (1) | ID25548A (es) |
IL (2) | IL134086A0 (es) |
IS (2) | IS2027B (es) |
MY (1) | MY116761A (es) |
NO (1) | NO325324B1 (es) |
NZ (1) | NZ502298A (es) |
PL (1) | PL193065B1 (es) |
PT (1) | PT996622E (es) |
RU (1) | RU2202553C2 (es) |
SA (1) | SA98190668B1 (es) |
SI (1) | SI0996622T1 (es) |
SK (1) | SK283484B6 (es) |
TR (1) | TR200000129T2 (es) |
TW (1) | TW515799B (es) |
WO (1) | WO1999003859A1 (es) |
Families Citing this family (110)
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US6277870B1 (en) * | 1998-05-04 | 2001-08-21 | Astra Ab | Use |
SE9900100D0 (sv) * | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
FR2790474B1 (fr) * | 1999-03-05 | 2001-04-06 | Synthelabo | Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique |
US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
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DK1397366T3 (da) * | 2001-06-01 | 2007-05-07 | Astrazeneca Ab | Hidtil ukendt ligander for nicotinacetylcholinreceptorer egnede i terapi |
US20040259909A1 (en) * | 2001-10-16 | 2004-12-23 | Mccarthy Dennis | Treatment of fibromyalgia syndrome |
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DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
US20030162770A1 (en) | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
EP1499618B1 (en) * | 2002-04-18 | 2010-10-13 | AstraZeneca AB | Furyl compounds |
US7186836B2 (en) * | 2002-04-18 | 2007-03-06 | Astrazeneca Ab | Thienyl compounds |
NZ561993A (en) * | 2002-04-18 | 2008-09-26 | Astrazeneca Ab | Spiroazabicyclic heterocyclic amines as potent ligands for nicotinic acetylcholine receptors |
US7091216B2 (en) | 2002-08-02 | 2006-08-15 | Merck & Co., Inc. | Substituted furo[2,3-b]pyridine derivatives |
SE0202598D0 (sv) * | 2002-09-02 | 2002-09-02 | Astrazeneca Ab | Alpha-7 Nicotinic receptor agonists and statins in combination |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
US7273872B2 (en) * | 2002-12-06 | 2007-09-25 | The Feinstein Institute For Medical Research | Inhibition of inflammation using α 7 receptor-binding cholinergic agonists |
US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
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US20050129610A1 (en) * | 2003-06-24 | 2005-06-16 | Johns Hopkins University | Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor |
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1998
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