PE20060437A1 - COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR - Google Patents

COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR

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Publication number
PE20060437A1
PE20060437A1 PE2005000689A PE2005000689A PE20060437A1 PE 20060437 A1 PE20060437 A1 PE 20060437A1 PE 2005000689 A PE2005000689 A PE 2005000689A PE 2005000689 A PE2005000689 A PE 2005000689A PE 20060437 A1 PE20060437 A1 PE 20060437A1
Authority
PE
Peru
Prior art keywords
aza
compounds
nachr
cholinergic
group
Prior art date
Application number
PE2005000689A
Other languages
English (en)
Inventor
Dominik Feuerbach
Werner Muller
Thomas J Troxler
Mathias Frederiksen
Konstanze Hurth
Bernard Lucien Roy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20060437A1 publication Critical patent/PE20060437A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Abstract

SE REFIERE A COMPUESTOS DE 1-AZA-BICICLOALQUILO DE FORMULA (I), EN DONDE A ES O O N(R1); Y ES UN GRUPO a), b), c), d), ENTRE OTROS, EN DONDE EL ENLACE IZQUIERDO ESTA UNIDO A UN GRUPO A Y EL DERECHO AL GRUPO R; R ES ARILO (C5-C10), HETEROARILO(C5-C10) OPCIONALMENTE SUSTITUIDOS, N(R1)(RR4) O N(R2)(CHR3R4), EN DONDE R1, R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C4) O CF3; R4 ES ARILO O HETEROARILO(C5-C10). SON PREFERIDOS: 4-[6-(2-FLUORO-4-METIL-FENIL)-PIRAZIN-3-ILOXI]1-AZA-BICICLO[3.3.1]NONANO, 4-[6-(2,5-DIFLUOROFENIL-4-METIL-FENIL)-PIRAZIN-3-ILOXI]1-AZA-BICICLO[3.3.1]NONANO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCESO DE PREPARACION. ESTOS COMPUESTOS SON LIGANDOS COLINERGICOS DE nAChR Y MUESTRAN ACTIVIDAD SELECTIVA EN EL RECEPTOR DE ACETIL COLINA NICOTINICO *7 nAChR, POR LO QUE SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS SICOTICOS Y NEURODEGENERATIVOS
PE2005000689A 2004-06-18 2005-06-16 COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR PE20060437A1 (es)

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US58102004P 2004-06-18 2004-06-18

Publications (1)

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PE20060437A1 true PE20060437A1 (es) 2006-06-08

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Country Link
US (3) US20070249657A1 (es)
EP (2) EP2336129A1 (es)
JP (1) JP4944772B2 (es)
KR (3) KR20120047317A (es)
CN (1) CN1964968A (es)
AR (1) AR049401A1 (es)
AT (1) ATE506362T1 (es)
AU (1) AU2005254689B2 (es)
BR (1) BRPI0510940A (es)
CA (1) CA2566155C (es)
CY (1) CY1111528T1 (es)
DE (1) DE602005027567D1 (es)
DK (1) DK1761533T3 (es)
EC (1) ECSP067053A (es)
ES (1) ES2364971T3 (es)
HK (1) HK1107559A1 (es)
HR (1) HRP20110535T1 (es)
IL (2) IL179611A (es)
MA (1) MA28684B1 (es)
MX (1) MXPA06014697A (es)
MY (1) MY147262A (es)
NO (1) NO20070339L (es)
NZ (1) NZ551198A (es)
PE (1) PE20060437A1 (es)
PL (1) PL1761533T3 (es)
PT (1) PT1761533E (es)
RU (1) RU2445313C2 (es)
SG (1) SG153834A1 (es)
SI (1) SI1761533T1 (es)
TN (1) TNSN06407A1 (es)
TW (1) TWI370128B (es)
WO (1) WO2005123732A1 (es)
ZA (1) ZA200609255B (es)

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