PE20070793A1 - Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos - Google Patents

Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos

Info

Publication number
PE20070793A1
PE20070793A1 PE2006001266A PE2006001266A PE20070793A1 PE 20070793 A1 PE20070793 A1 PE 20070793A1 PE 2006001266 A PE2006001266 A PE 2006001266A PE 2006001266 A PE2006001266 A PE 2006001266A PE 20070793 A1 PE20070793 A1 PE 20070793A1
Authority
PE
Peru
Prior art keywords
dihydro
quinolin
ona
compounds containing
containing nitrogen
Prior art date
Application number
PE2006001266A
Other languages
English (en)
Inventor
Nathalie Cailleau
David Thomas Davies
Joel Michael Esken
Alan Joseph Hennessy
Sukumar Senthil Kumar Kusalakumari
Roger Edward Markwell
Timothy James Miles
Neil David Pearson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070793A1 publication Critical patent/PE20070793A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS 1,2-DIHIDRO-4H-PIRROLO[3,2,1-ij]QUINOLIN-4-ONA SUSTITUIDOS DE FORMULA (I), EN DONDE R1a Y R1b SON INDEPENDIENTEMENTE H, HALOGENO, CIANO, ALQUILO(C1-C6), TRIFLUOROMETILO, ENTRE OTROS; R2 ES H O ALQUIL(C1-C4); A ES UN GRUPO ia), ib) O ii); U ES CO Y CH2; R5 ES UN SISTEMA DE ANILLO BICICLICO, CARBOCICLICO O HETEROCICLICO DE FORMULA B) OPCIONALMENTE SUSTITUIDO; R9 MES H O HIDROXI. SON PREFERIDOS 1-({4-[(2,3-DIHIDRO-[1,4]DIOXINO[2,3-c]PIRIDIN-7-ILMETIL)AMINO]-1-PIPERIDINIL}METIL)-9-FLUORO-1,2-DIHIDRO-4H-PIRROLO[3,2,1-ij]QUINOLIN-4-ONA, 9-FLUORO-1-({(3R,4S)-3-HIDROXI-4-[([1,3]OXATIOLO[5,4-c]PIRIDIN-6-ILMETIL)AMINO]-1-PIPERIDINIL}METIL)-1,2-DIHIDRO-4H-PIRROLO[3,2,1-ij]QUINOLIN-4-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD ANTIBACTERIANA Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS ORIGINADAS POR ORGANISMOS GRAM NEGATIVOS COMO GRAM PROSITIVOS
PE2006001266A 2005-10-21 2006-10-19 Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos PE20070793A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72897505P 2005-10-21 2005-10-21
US82659006P 2006-09-22 2006-09-22

Publications (1)

Publication Number Publication Date
PE20070793A1 true PE20070793A1 (es) 2007-08-23

Family

ID=38256822

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001266A PE20070793A1 (es) 2005-10-21 2006-10-19 Compuestos triciclicos que contienen nitrogeno como agentes antibacterianos

Country Status (27)

Country Link
US (2) US20080221110A1 (es)
EP (1) EP1954697B1 (es)
JP (1) JP2009512695A (es)
KR (1) KR20080064173A (es)
AR (1) AR057981A1 (es)
AT (1) ATE458737T1 (es)
AU (1) AU2006335042A1 (es)
BR (1) BRPI0617467A2 (es)
CA (1) CA2626641A1 (es)
CR (1) CR9930A (es)
CY (1) CY1110137T1 (es)
DE (1) DE602006012535D1 (es)
DK (1) DK1954697T3 (es)
EA (1) EA200801128A1 (es)
ES (1) ES2340531T3 (es)
HK (1) HK1118546A1 (es)
HR (1) HRP20100194T8 (es)
IL (1) IL190803A0 (es)
MA (1) MA29873B1 (es)
NO (1) NO20082191L (es)
NZ (1) NZ567315A (es)
PE (1) PE20070793A1 (es)
PL (1) PL1954697T3 (es)
PT (1) PT1954697E (es)
SI (1) SI1954697T1 (es)
TW (1) TW200736263A (es)
WO (1) WO2007081597A2 (es)

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JP5653935B2 (ja) 2009-01-15 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物
WO2013038374A1 (en) 2011-09-16 2013-03-21 Actelion Pharmaceuticals Ltd Process for manufacturing a synthetic intermediate
JP2014533747A (ja) 2011-11-30 2014-12-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ３，７−二置換オクタヒドロ−２Ｈ−ピリド［４，３−ｅ］［１，３］オキサジン−２−オン抗生物質
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Also Published As

Publication number Publication date
US20080221110A1 (en) 2008-09-11
SI1954697T1 (sl) 2010-05-31
EP1954697B1 (en) 2010-02-24
HRP20100194T1 (hr) 2010-05-31
HRP20100194T8 (en) 2010-06-30
WO2007081597A3 (en) 2008-06-12
ES2340531T3 (es) 2010-06-04
EP1954697A2 (en) 2008-08-13
CA2626641A1 (en) 2007-07-19
PT1954697E (pt) 2010-05-17
AR057981A1 (es) 2008-01-09
ATE458737T1 (de) 2010-03-15
JP2009512695A (ja) 2009-03-26
EA200801128A1 (ru) 2008-10-30
MA29873B1 (fr) 2008-10-03
NZ567315A (en) 2011-01-28
DE602006012535D1 (de) 2010-04-08
NO20082191L (no) 2008-07-16
CR9930A (es) 2008-07-29
KR20080064173A (ko) 2008-07-08
US20080280892A1 (en) 2008-11-13
BRPI0617467A2 (pt) 2011-07-26
CY1110137T1 (el) 2015-01-14
WO2007081597A2 (en) 2007-07-19
PL1954697T3 (pl) 2010-07-30
AU2006335042A1 (en) 2007-07-19
HK1118546A1 (en) 2009-02-13
DK1954697T3 (da) 2010-06-14
IL190803A0 (en) 2008-12-29
TW200736263A (en) 2007-10-01

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