PE20071064A1 - Derivados de pirrolonaftiridinonas como antibacterianos - Google Patents
Derivados de pirrolonaftiridinonas como antibacterianosInfo
- Publication number
- PE20071064A1 PE20071064A1 PE2006001655A PE2006001655A PE20071064A1 PE 20071064 A1 PE20071064 A1 PE 20071064A1 PE 2006001655 A PE2006001655 A PE 2006001655A PE 2006001655 A PE2006001655 A PE 2006001655A PE 20071064 A1 PE20071064 A1 PE 20071064A1
- Authority
- PE
- Peru
- Prior art keywords
- dihydro
- hydroxy
- alkyl
- methyl
- cr4r8
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A DERIVADOS DE PIRROLONAFTIRIDINONA DE FORMULA (I), DONDE R1a Y R1b SON H, HALOGENO, CIANO, ALQUILO C1-C6, OH, ENTRE OTROS; R2 ES H, ALQUILO C1-C4, ENTRE OTROS; A ES UN GRUPO (ia) O (ib), DONDE R3 ES COMO SE HA DEFINIDO PARA R1a O R1b O ES OXO, n ES 1 O 2; A ES UN GRUPO (ii), DONDE W1, W2 Y W3 SON CR4R8 O W2 Y W3 SON CR4R8 Y W1 ES UN ENLACE ENTRE W3 Y N; X ES O, CR4R8 O NR6; R4 ES COMO SE DEFINE PARA R1a Y R1b; R8 ES H; R6 ES H O ALQUILO C1-C6; R7 ES H, HALOGENO, OH, ENTRE OTROS; U ES CO, CH2; R5 ES UN ANILLO BICICLICO CARBOCICLICO O HETEROCICLICO (B), DONDE AL MENOS UNO DE LOS ANILLOS (a) Y (b) ES AROMATICO; X1 ES C, N O CR14; X2 ES N, NR13, O CO, ENTRE OTROS; X3 Y X5 SON N O C; Y1 Y Y2 SON GRUPOS CONECTORES DE 0 A 4 ATOMOS TAL COMO N, CO, ENTRE OTROS; R14 ES H, ALQUILTIO C1-C4, ALQUILO C1-C4, ENTRE OTROS; R9 ES FLUORO O HIDROXI. SON COMPUESTOS PREFERIDOS: (4S)-4-({4-[(2,3-DIHIDRO[1,4]DIOXINO[2,3-c]PIRIDIN-7-ILMETIL)AMINO]-1-PIPERIDINIL}METIL)-3-FLUORO-4-HIDROXI-4,5-DIHIDRO-7H-PIRROLO[3,2,1-de]-1,5-NAFTIRIDIN-7-ONA, (4S)-3-FLUORO-4-HIDROXI-4-[(4-{[(3-OXO-3,4-DIHIDRO-2H-PIRIDO[3,2-b][1,4]TIAZIN-6-IL)METIL]AMINO}-1-PIPERIDINIL)METIL]-4,5-DIHIDRO-7H-PIRROLO[3,2,1-de]-1,5-NAFTIRIDIN-7-ONA, (4R)-4-({4-[(2,3-DIHIDRO[1,4]OXATIINO[2,3-c]PIRIDIN-7-ILMETIL)AMINO]-1-PIPERIDINIL}METIL)-3-FLUORO-4-HIDROXI-4,5-DIHIDRO-7H-PIRROLO[3,2,1-de]-1,5-NAFTIRIDIN-7-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES COMO ANTIBACTERIANOS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75314905P | 2005-12-22 | 2005-12-22 | |
| US86687706P | 2006-11-22 | 2006-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071064A1 true PE20071064A1 (es) | 2007-12-16 |
Family
ID=37763790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001655A PE20071064A1 (es) | 2005-12-22 | 2006-12-20 | Derivados de pirrolonaftiridinonas como antibacterianos |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7732460B2 (es) |
| EP (1) | EP1963324B1 (es) |
| JP (1) | JP2009520779A (es) |
| AR (1) | AR058587A1 (es) |
| AT (1) | ATE465163T1 (es) |
| DE (1) | DE602006013878D1 (es) |
| ES (1) | ES2344523T3 (es) |
| PE (1) | PE20071064A1 (es) |
| TW (1) | TW200801001A (es) |
| WO (1) | WO2007071936A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1954697T3 (da) * | 2005-10-21 | 2010-06-14 | Glaxo Group Ltd | Peri-kondenserede tricykliske forbindelser, der er anvendelige som antibakterielle midler |
| WO2007115947A1 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| GB0608263D0 (en) * | 2006-04-26 | 2006-06-07 | Glaxo Group Ltd | Compounds |
| GB0613208D0 (en) * | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| GB0705672D0 (en) * | 2007-03-23 | 2007-05-02 | Glaxo Group Ltd | Compounds |
| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| GB0707706D0 (en) * | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| AU2008240764C1 (en) * | 2007-04-20 | 2011-10-20 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| EP2005995A1 (en) * | 2007-06-22 | 2008-12-24 | Glaxo Group Limited | Heterocyclic compounds for the treatment of tuberculosis |
| BRPI0820394A2 (pt) * | 2007-11-26 | 2015-05-19 | Toyama Chemical Co Ltd | Composto, método para produzir um composto, derivado do ácido kójico, e, agente antibacteriano. |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| MX2010008922A (es) * | 2008-02-20 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos azatriciclicos. |
| WO2009104159A1 (en) | 2008-02-22 | 2009-08-27 | Actelion Pharmaceuticals Ltd | Oxazolidinone derivatives |
| WO2009125809A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | ピペリジン誘導体 |
| WO2009125808A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | アミノシクロヘキシル誘導体 |
| EP2276766A1 (en) | 2008-04-15 | 2011-01-26 | Actelion Pharmaceuticals Ltd. | Tricyclic antibiotics |
| JP2011520944A (ja) * | 2008-05-23 | 2011-07-21 | グラクソ グループ リミテッド | 窒素含有三環式化合物および抗菌剤としてのその使用 |
| JP5474941B2 (ja) * | 2008-05-23 | 2014-04-16 | グラクソ グループ リミテッド | 窒素含有三環式化合物およびその抗菌剤としての使用 |
| AR073774A1 (es) * | 2008-10-07 | 2010-12-01 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos oxazolidinona triciclicos |
| US20110275661A1 (en) * | 2008-10-17 | 2011-11-10 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| JP4955835B2 (ja) | 2008-12-12 | 2012-06-20 | アクテリオン ファーマシューティカルズ リミテッド | ５−アミノ−２−（１−ヒドロキシ−エチル）−テトラヒドロピラン誘導体 |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| TW201313726A (zh) | 2011-09-16 | 2013-04-01 | Actelion Pharmaceuticals Ltd | 製造合成之中間體之方法 |
| JP2014533747A (ja) | 2011-11-30 | 2014-12-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ３，７−二置換オクタヒドロ−２Ｈ−ピリド［４，３−ｅ］［１，３］オキサジン−２−オン抗生物質 |
| MX2017002321A (es) | 2014-08-22 | 2017-08-02 | Glaxosmithkline Ip Dev Ltd | Compuestos que contienen nitrogeno triciclico para tratar infeccion por neisseria gonorrhoeae. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112836D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| JP4508650B2 (ja) * | 2002-01-29 | 2010-07-21 | グラクソ グループ リミテッド | アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物 |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| JP2007522093A (ja) | 2003-09-22 | 2007-08-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ７−アミノアルキリデニル−複素環式キノロンおよびナフチリドン |
| US7732612B2 (en) | 2004-09-09 | 2010-06-08 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| DK1954697T3 (da) | 2005-10-21 | 2010-06-14 | Glaxo Group Ltd | Peri-kondenserede tricykliske forbindelser, der er anvendelige som antibakterielle midler |
| WO2007115947A1 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| GB0608263D0 (en) | 2006-04-26 | 2006-06-07 | Glaxo Group Ltd | Compounds |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
-
2006
- 2006-12-15 EP EP06831388A patent/EP1963324B1/en active Active
- 2006-12-15 DE DE602006013878T patent/DE602006013878D1/de active Active
- 2006-12-15 AT AT06831388T patent/ATE465163T1/de not_active IP Right Cessation
- 2006-12-15 US US12/158,397 patent/US7732460B2/en not_active Expired - Fee Related
- 2006-12-15 US US11/611,214 patent/US20070185153A1/en not_active Abandoned
- 2006-12-15 WO PCT/GB2006/004686 patent/WO2007071936A1/en active Application Filing
- 2006-12-15 JP JP2008546579A patent/JP2009520779A/ja active Pending
- 2006-12-15 ES ES06831388T patent/ES2344523T3/es active Active
- 2006-12-20 TW TW095147764A patent/TW200801001A/zh unknown
- 2006-12-20 AR ARP060105654A patent/AR058587A1/es unknown
- 2006-12-20 PE PE2006001655A patent/PE20071064A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006013878D1 (de) | 2010-06-02 |
| EP1963324B1 (en) | 2010-04-21 |
| ES2344523T3 (es) | 2010-08-30 |
| TW200801001A (en) | 2008-01-01 |
| EP1963324A1 (en) | 2008-09-03 |
| US7732460B2 (en) | 2010-06-08 |
| US20090036433A1 (en) | 2009-02-05 |
| JP2009520779A (ja) | 2009-05-28 |
| WO2007071936A1 (en) | 2007-06-28 |
| ATE465163T1 (de) | 2010-05-15 |
| AR058587A1 (es) | 2008-02-13 |
| US20070185153A1 (en) | 2007-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |