PE20080988A1 - Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa - Google Patents
Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasaInfo
- Publication number
- PE20080988A1 PE20080988A1 PE2007000685A PE2007000685A PE20080988A1 PE 20080988 A1 PE20080988 A1 PE 20080988A1 PE 2007000685 A PE2007000685 A PE 2007000685A PE 2007000685 A PE2007000685 A PE 2007000685A PE 20080988 A1 PE20080988 A1 PE 20080988A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- gama
- sulfonamide
- pirazol
- dihydro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
Abstract
SE REFIERE A COMPUESTOS TRICICLICOS FUSIONADOS DE SULFONAMIDA DE FORMULA (I), EN DONDE C ES CICLOALQUILO, ARILO, HETEROCICLOALQUILO O HETEROARILO, SUSTITUIDOS CON 1 A 4 GRUPOS DE HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; EL ANILLO A ES ARILO, CICLOALQUILO, HETEROARILO O HETEROCICLOALQUILO, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; EL ANILLO B ES HETEROARILO O HETEROCICLOALQUILO, OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6), ALCOXI(C1-C6), NR'R'', ENTRE OTROS; R1 ES H O ALQUILO(C1-C6); R2 ES H, ALQUILO(C1-C6), -NO2, -C(O)OR', ENTRE OTROS. SON COMPUESTOS PREFERIDOS; 5-[(4-CLOROFENIL)SULFONIL]-4,5-DIHIDRO-1H-PIRAZOL[4,3-c]QUINOLINA, 5-(4-CLOROFENILSULFONIL)-7-FLUORO-4-METIL-4,5-DIHIDRO-2H-PIRAZOL[4,3-c]QUINOLINA, 4-CICLOPROPIL-7,8-DIFLUORO-5-(TIOFEN-2-ILSULFONIL)-4,5-DIHIDRO-2H-PIRAZOL[4,3-e]PIRIMIDINA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS INHIBEN LA SINTESIS Y LIBERACION DEL PEPTIDO ß-AMILOIDE, GAMA-SECRETASA, SIENDO UTILES EN EL TRATAMIENTO Y PREVENCION DE TRANSTORNOS COGNITIVOS, COMO ALZHEIMER O DEMENCIA
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81043106P | 2006-06-02 | 2006-06-02 | |
US87693206P | 2006-12-22 | 2006-12-22 | |
US92277107P | 2007-04-10 | 2007-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080988A1 true PE20080988A1 (es) | 2008-08-15 |
Family
ID=38686795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000685A PE20080988A1 (es) | 2006-06-02 | 2007-06-01 | Compuestos triciclicos fusionados de sulfonamida como inhibidores de gama-secretasa |
Country Status (22)
Country | Link |
---|---|
US (1) | US20080021056A1 (es) |
EP (2) | EP2038280A2 (es) |
JP (1) | JP2009539773A (es) |
KR (1) | KR20090015159A (es) |
CN (2) | CN101501032B (es) |
AR (1) | AR061161A1 (es) |
AU (1) | AU2007256860A1 (es) |
BR (1) | BRPI0712123A2 (es) |
CA (1) | CA2651550A1 (es) |
EA (1) | EA200870577A1 (es) |
EC (1) | ECSP089019A (es) |
IL (1) | IL195078A0 (es) |
MA (1) | MA30532B1 (es) |
MX (1) | MX2008014947A (es) |
MY (1) | MY169274A (es) |
NO (1) | NO20085323L (es) |
NZ (1) | NZ572885A (es) |
PE (1) | PE20080988A1 (es) |
SG (1) | SG172629A1 (es) |
TW (1) | TW200813054A (es) |
UY (1) | UY30377A1 (es) |
WO (1) | WO2007143523A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102702044A (zh) | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
CA2687765A1 (en) | 2007-05-25 | 2008-12-04 | Elan Pharmaceuticals, Inc. | Pyrazolopyrrolidines as inhibitors of gamma secretase |
RU2483061C2 (ru) * | 2007-07-05 | 2013-05-27 | Шеринг Корпорейшн | Тетрагидропиранохроменовые ингибиторы гамма-секретазы |
KR20100044840A (ko) | 2007-07-17 | 2010-04-30 | 쉐링 코포레이션 | 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련 감마 세크레타제 억제제 |
US8283358B2 (en) * | 2008-09-05 | 2012-10-09 | Elan Pharmaceuticals, Inc. | N-sulfonamido polycyclic pyrazolyl compounds |
JP2012521993A (ja) * | 2009-03-25 | 2012-09-20 | エラン ファーマシューティカルズ,インコーポレイテッド | 縮合三環式スルホンアミドの製造プロセス |
US8293744B2 (en) | 2009-04-20 | 2012-10-23 | Merck Sharp & Dohme Corp. | Heterocyclic fused cinnoline M1 receptor positive allosteric modulators |
US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
WO2012033831A2 (en) | 2010-09-07 | 2012-03-15 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for gamma-secretase assay |
US10319527B2 (en) * | 2017-04-04 | 2019-06-11 | Samsung Electro-Mechanics Co., Ltd. | Multilayer capacitor |
CN110526913B (zh) * | 2019-08-30 | 2022-04-29 | 中国药科大学 | 一种抗凝药物阿哌沙班相关物质的制备方法 |
CN114853707B (zh) * | 2022-06-13 | 2024-01-26 | 上饶师范学院 | 一种合成二氟氢甲基化2,3-二氢苯并吡喃-4-酮衍生物的方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
JPH0977752A (ja) * | 1995-09-12 | 1997-03-25 | Kao Corp | N−無置換イソオキサゾリジンの製造法 |
GB9720899D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
EP1492765B1 (en) * | 2001-08-03 | 2011-07-06 | Schering Corporation | Novel gamma secretase inhibitors |
DE60220422T2 (de) * | 2001-09-19 | 2008-02-07 | Pharmacia Corp. | Substituierte pyrazol-verbindungen zur behandlung von entzündungen |
JP2006151810A (ja) * | 2002-12-26 | 2006-06-15 | Daiichi Asubio Pharma Co Ltd | ジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤 |
US20060264380A1 (en) | 2003-07-21 | 2006-11-23 | Mats Hellstrom | Compounds and Methods for Promoting Angiogenesis |
EP1758884A2 (en) * | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
WO2006068928A1 (en) * | 2004-12-20 | 2006-06-29 | Wyeth | Pyrrolo[1,2-a]quinoxalin-5-(4h)-yl)sulfonyls and carbonyls and their use as estrogenic agents |
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2007
- 2007-05-31 TW TW096119621A patent/TW200813054A/zh unknown
- 2007-05-31 UY UY30377A patent/UY30377A1/es unknown
- 2007-06-01 EP EP07797980A patent/EP2038280A2/en not_active Withdrawn
- 2007-06-01 PE PE2007000685A patent/PE20080988A1/es not_active Application Discontinuation
- 2007-06-01 MX MX2008014947A patent/MX2008014947A/es not_active Application Discontinuation
- 2007-06-01 CN CN2007800288411A patent/CN101501032B/zh not_active Expired - Fee Related
- 2007-06-01 CA CA002651550A patent/CA2651550A1/en not_active Abandoned
- 2007-06-01 US US11/757,140 patent/US20080021056A1/en not_active Abandoned
- 2007-06-01 EP EP11181803A patent/EP2450358A1/en not_active Withdrawn
- 2007-06-01 AU AU2007256860A patent/AU2007256860A1/en not_active Abandoned
- 2007-06-01 WO PCT/US2007/070176 patent/WO2007143523A2/en active Application Filing
- 2007-06-01 BR BRPI0712123-7A patent/BRPI0712123A2/pt not_active IP Right Cessation
- 2007-06-01 EA EA200870577A patent/EA200870577A1/ru unknown
- 2007-06-01 CN CN2012103016479A patent/CN102850349A/zh active Pending
- 2007-06-01 AR ARP070102379A patent/AR061161A1/es not_active Application Discontinuation
- 2007-06-01 MY MYPI20084826A patent/MY169274A/en unknown
- 2007-06-01 SG SG2011037546A patent/SG172629A1/en unknown
- 2007-06-01 JP JP2009513467A patent/JP2009539773A/ja active Pending
- 2007-06-01 NZ NZ572885A patent/NZ572885A/en not_active IP Right Cessation
- 2007-06-01 KR KR1020087031953A patent/KR20090015159A/ko not_active Application Discontinuation
-
2008
- 2008-11-03 IL IL195078A patent/IL195078A0/en unknown
- 2008-12-19 NO NO20085323A patent/NO20085323L/no not_active Application Discontinuation
- 2008-12-26 MA MA31514A patent/MA30532B1/fr unknown
- 2008-12-29 EC EC2008009019A patent/ECSP089019A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0712123A2 (pt) | 2012-07-10 |
TW200813054A (en) | 2008-03-16 |
US20080021056A1 (en) | 2008-01-24 |
KR20090015159A (ko) | 2009-02-11 |
AR061161A1 (es) | 2008-08-06 |
SG172629A1 (en) | 2011-07-28 |
ECSP089019A (es) | 2009-02-27 |
AU2007256860A1 (en) | 2007-12-13 |
CA2651550A1 (en) | 2007-12-13 |
UY30377A1 (es) | 2008-01-02 |
EP2450358A1 (en) | 2012-05-09 |
MX2008014947A (es) | 2008-12-10 |
NO20085323L (no) | 2009-02-24 |
MA30532B1 (fr) | 2009-06-01 |
MY169274A (en) | 2019-03-21 |
JP2009539773A (ja) | 2009-11-19 |
EA200870577A1 (ru) | 2009-06-30 |
CN101501032B (zh) | 2012-10-10 |
WO2007143523A2 (en) | 2007-12-13 |
CN101501032A (zh) | 2009-08-05 |
WO2007143523A8 (en) | 2008-01-31 |
NZ572885A (en) | 2012-02-24 |
CN102850349A (zh) | 2013-01-02 |
WO2007143523A3 (en) | 2008-06-12 |
EP2038280A2 (en) | 2009-03-25 |
IL195078A0 (en) | 2009-08-03 |
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