EA200870577A1 - Конденсированные трициклические сульфонамидные ингибиторы гамма-секретазы - Google Patents

Конденсированные трициклические сульфонамидные ингибиторы гамма-секретазы

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Publication number
EA200870577A1
EA200870577A1 EA200870577A EA200870577A EA200870577A1 EA 200870577 A1 EA200870577 A1 EA 200870577A1 EA 200870577 A EA200870577 A EA 200870577A EA 200870577 A EA200870577 A EA 200870577A EA 200870577 A1 EA200870577 A1 EA 200870577A1
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Eurasian Patent Office
Prior art keywords
secretases
compounds
formula
condensed tricyclic
sulphonamide
Prior art date
Application number
EA200870577A
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English (en)
Inventor
Андрей В. Конради
Гэри Пробст
Даниелль Л. Обель
Альберт В. Гарофэло
Рой Хом
Мартин Л. Нэйтзел
Кристофер М. Семко
Анх П. Труонг
Original Assignee
Элан Фармасьютикалз, Инк.
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Application filed by Элан Фармасьютикалз, Инк. filed Critical Элан Фармасьютикалз, Инк.
Publication of EA200870577A1 publication Critical patent/EA200870577A1/ru

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Abstract

Изобретение относится к соединениям формулы Iили к их фармацевтически приемлемым солям, где R, Rи А, В и С-кольца имеют определенные здесь значения. Соединения формулы I могут быть использованы в лечении или профилактике когнитивных нарушений, таких как болезнь Альцгеймера. Изобретение также охватывает фармацевтические композиции, содержащие соединения или соли формулы I, способы получения желаемых соединений и способы лечения когнитивных нарушений, таких как болезнь Альцгеймера, с использованием соединений или солей формулы I.
EA200870577A 2006-06-02 2007-06-01 Конденсированные трициклические сульфонамидные ингибиторы гамма-секретазы EA200870577A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81043106P 2006-06-02 2006-06-02
US87693206P 2006-12-22 2006-12-22
US92277107P 2007-04-10 2007-04-10
PCT/US2007/070176 WO2007143523A2 (en) 2006-06-02 2007-06-01 Fused, tricyclic sulfonamide inhibitors of gamma secretase

Publications (1)

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EA200870577A1 true EA200870577A1 (ru) 2009-06-30

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US (1) US20080021056A1 (ru)
EP (2) EP2038280A2 (ru)
JP (1) JP2009539773A (ru)
KR (1) KR20090015159A (ru)
CN (2) CN101501032B (ru)
AR (1) AR061161A1 (ru)
AU (1) AU2007256860A1 (ru)
BR (1) BRPI0712123A2 (ru)
CA (1) CA2651550A1 (ru)
EA (1) EA200870577A1 (ru)
EC (1) ECSP089019A (ru)
IL (1) IL195078A0 (ru)
MA (1) MA30532B1 (ru)
MX (1) MX2008014947A (ru)
MY (1) MY169274A (ru)
NO (1) NO20085323L (ru)
NZ (1) NZ572885A (ru)
PE (1) PE20080988A1 (ru)
SG (1) SG172629A1 (ru)
TW (1) TW200813054A (ru)
UY (1) UY30377A1 (ru)
WO (1) WO2007143523A2 (ru)

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BRPI0712123A2 (pt) 2012-07-10
CN102850349A (zh) 2013-01-02
WO2007143523A2 (en) 2007-12-13
US20080021056A1 (en) 2008-01-24
ECSP089019A (es) 2009-02-27
CN101501032A (zh) 2009-08-05
WO2007143523A8 (en) 2008-01-31
IL195078A0 (en) 2009-08-03
MA30532B1 (fr) 2009-06-01
MY169274A (en) 2019-03-21
NO20085323L (no) 2009-02-24
AU2007256860A1 (en) 2007-12-13
UY30377A1 (es) 2008-01-02
KR20090015159A (ko) 2009-02-11
EP2450358A1 (en) 2012-05-09
JP2009539773A (ja) 2009-11-19
PE20080988A1 (es) 2008-08-15
NZ572885A (en) 2012-02-24
CN101501032B (zh) 2012-10-10
CA2651550A1 (en) 2007-12-13
AR061161A1 (es) 2008-08-06
WO2007143523A3 (en) 2008-06-12
TW200813054A (en) 2008-03-16
SG172629A1 (en) 2011-07-28
MX2008014947A (es) 2008-12-10
EP2038280A2 (en) 2009-03-25

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