EA200801481A1 - 5-(арилсульфонил)пиразолопиперидины - Google Patents
5-(арилсульфонил)пиразолопиперидиныInfo
- Publication number
- EA200801481A1 EA200801481A1 EA200801481A EA200801481A EA200801481A1 EA 200801481 A1 EA200801481 A1 EA 200801481A1 EA 200801481 A EA200801481 A EA 200801481A EA 200801481 A EA200801481 A EA 200801481A EA 200801481 A1 EA200801481 A1 EA 200801481A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- formula
- compounds
- pyrazolopiperides
- arosulfonyl
- alzheimer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к N-циклическим сульфонамидным соединениям формулы I в которой A, B, R, R, R, R, Rи Rявляются такими, как описано в описании. Соединения формулы I могут быть использованы в лечении или профилактике когнитивных нарушений, таких как болезнь Альцгеймера. Изобретение также охватывает фармацевтические композиции, включающие соединения формулы I, способы получения соединений формулы I и способы лечения когнитивных нарушений, таких как болезнь Альцгеймера.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74136605P | 2005-12-01 | 2005-12-01 | |
PCT/US2006/046039 WO2007064914A2 (en) | 2005-12-01 | 2006-12-01 | 5-(arylsulfonyl)-pyrazolopiperidines |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200801481A1 true EA200801481A1 (ru) | 2009-02-27 |
EA014906B1 EA014906B1 (ru) | 2011-02-28 |
Family
ID=38092841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801481A EA014906B1 (ru) | 2005-12-01 | 2006-12-01 | 5-(арилсульфонил)пиразолопиперидины |
Country Status (18)
Country | Link |
---|---|
US (2) | US7732609B2 (ru) |
EP (1) | EP1957458A2 (ru) |
JP (1) | JP2009518301A (ru) |
KR (1) | KR20080073359A (ru) |
CN (1) | CN101370776A (ru) |
AR (1) | AR057959A1 (ru) |
AU (1) | AU2006320423B2 (ru) |
BR (1) | BRPI0619633A2 (ru) |
CA (1) | CA2632227A1 (ru) |
EA (1) | EA014906B1 (ru) |
EC (1) | ECSP088593A (ru) |
IL (1) | IL190608A0 (ru) |
MA (1) | MA30089B1 (ru) |
MY (1) | MY149422A (ru) |
NZ (1) | NZ568109A (ru) |
PE (1) | PE20071090A1 (ru) |
TW (1) | TW200736255A (ru) |
WO (1) | WO2007064914A2 (ru) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2653506A1 (en) * | 2006-05-31 | 2007-12-06 | Galapagos Nv. | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases |
US7977368B2 (en) | 2007-05-25 | 2011-07-12 | Elan Pharmaceuticals, Inc. | Pyrazolopyrrolidines as inhibitors of gamma secretase |
CN102083797B (zh) | 2008-04-01 | 2014-06-04 | Abbvie公司 | 四氢异喹啉、含有它们的药物组合物和它们在治疗中的用途 |
AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
TW201038569A (en) * | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
JP2012521993A (ja) * | 2009-03-25 | 2012-09-20 | エラン ファーマシューティカルズ,インコーポレイテッド | 縮合三環式スルホンアミドの製造プロセス |
US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
JP2014521682A (ja) | 2011-08-05 | 2014-08-28 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミノクロマン、アミノチオクロマンおよびアミノ−1,2,3,4−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用 |
WO2013072520A1 (en) | 2011-11-18 | 2013-05-23 | AbbVie Deutschland GmbH & Co. KG | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
CA2924689A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
EP3057958B1 (en) | 2013-10-17 | 2019-05-01 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
CN104059063A (zh) * | 2014-04-03 | 2014-09-24 | 丽水绿氟科技有限公司 | 7,7-二氟-4,5,6,7-四氢吡唑并[4,3-c]吡啶及其衍生物的制备方法 |
UA128288C2 (uk) | 2018-03-08 | 2024-05-29 | Інсайт Корпорейшн | СПОЛУКИ АМІНОПІРАЗИНДІОЛУ ЯК ІНГІБІТОРИ PI3K-<font face="Symbol">g</font> |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1050129C (zh) | 1994-10-20 | 2000-03-08 | 美国辉瑞有限公司 | 二环四氢吡唑并吡啶和其作为药物的应用 |
PL213199B1 (pl) * | 2000-08-10 | 2013-01-31 | Pharmacia Italia Spa | Zwiazek bicyklo-pirazolowy, sposób wytwarzania go, jego kompozycja farmaceutyczna, oraz kombinatoryczna biblioteka chemiczna |
ATE417845T1 (de) * | 2001-10-09 | 2009-01-15 | Kyorin Seiyaku Kk | Neue 4-(2-furoyl)-amino-piperidine, zwischenprodukte für deren synthese, verfahren zu deren herstellung und deren medizinische verwendung |
AU2003292724A1 (en) * | 2002-12-27 | 2004-07-29 | Japan Tobacco Inc. | Fused n-containing heterocyclic compounds and medicinal use thereof |
WO2005113542A2 (en) * | 2004-05-20 | 2005-12-01 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
DE602005026037D1 (de) | 2004-10-27 | 2011-03-03 | Janssen Pharmaceutica Nv | Tetrahydro pyridinyl pyrazole cannabinoid modulatoren |
DE102005002500A1 (de) * | 2005-01-19 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen |
US20100113502A1 (en) * | 2005-03-22 | 2010-05-06 | Astrazeneca Ab | Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands |
DE102005016170A1 (de) * | 2005-04-07 | 2006-10-12 | Grünenthal GmbH | 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
JP2009506988A (ja) * | 2005-08-19 | 2009-02-19 | エラン ファーマシューティカルズ,インコーポレイテッド | ガンマセクレターゼの架橋n−環状スルホンアミド阻害剤 |
-
2006
- 2006-12-01 CA CA002632227A patent/CA2632227A1/en not_active Abandoned
- 2006-12-01 BR BRPI0619633-0A patent/BRPI0619633A2/pt not_active Application Discontinuation
- 2006-12-01 EP EP06844721A patent/EP1957458A2/en not_active Withdrawn
- 2006-12-01 KR KR1020087015935A patent/KR20080073359A/ko not_active Application Discontinuation
- 2006-12-01 WO PCT/US2006/046039 patent/WO2007064914A2/en active Application Filing
- 2006-12-01 AU AU2006320423A patent/AU2006320423B2/en not_active Ceased
- 2006-12-01 EA EA200801481A patent/EA014906B1/ru not_active IP Right Cessation
- 2006-12-01 PE PE2006001542A patent/PE20071090A1/es not_active Application Discontinuation
- 2006-12-01 AR ARP060105326A patent/AR057959A1/es not_active Application Discontinuation
- 2006-12-01 JP JP2008543496A patent/JP2009518301A/ja active Pending
- 2006-12-01 MY MYPI20081060A patent/MY149422A/en unknown
- 2006-12-01 CN CNA2006800451866A patent/CN101370776A/zh active Pending
- 2006-12-01 NZ NZ568109A patent/NZ568109A/en not_active IP Right Cessation
- 2006-12-01 TW TW095144766A patent/TW200736255A/zh unknown
- 2006-12-01 US US11/566,070 patent/US7732609B2/en not_active Expired - Fee Related
-
2008
- 2008-04-03 IL IL190608A patent/IL190608A0/en unknown
- 2008-06-26 MA MA31080A patent/MA30089B1/fr unknown
- 2008-07-01 EC EC2008008593A patent/ECSP088593A/es unknown
-
2010
- 2010-06-08 US US12/796,441 patent/US20100267747A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ568109A (en) | 2011-07-29 |
US7732609B2 (en) | 2010-06-08 |
BRPI0619633A2 (pt) | 2011-10-04 |
WO2007064914A2 (en) | 2007-06-07 |
AU2006320423A1 (en) | 2007-06-07 |
JP2009518301A (ja) | 2009-05-07 |
WO2007064914A8 (en) | 2008-05-15 |
ECSP088593A (es) | 2008-08-29 |
US20100267747A1 (en) | 2010-10-21 |
EP1957458A2 (en) | 2008-08-20 |
CN101370776A (zh) | 2009-02-18 |
TW200736255A (en) | 2007-10-01 |
IL190608A0 (en) | 2008-11-03 |
MA30089B1 (fr) | 2008-12-01 |
CA2632227A1 (en) | 2007-06-07 |
MY149422A (en) | 2013-08-30 |
KR20080073359A (ko) | 2008-08-08 |
AR057959A1 (es) | 2007-12-26 |
PE20071090A1 (es) | 2007-10-24 |
WO2007064914A3 (en) | 2007-12-27 |
US20070155753A1 (en) | 2007-07-05 |
AU2006320423B2 (en) | 2012-06-21 |
EA014906B1 (ru) | 2011-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200801481A1 (ru) | 5-(арилсульфонил)пиразолопиперидины | |
EP1841426A4 (en) | TERTIARY CARBINAMINES INCLUDING SUBSTITUTED HETEROCYCLES AS BETA SECRETASE INHIBITORS AND FOR THE TREATMENT OF ALZHEIMER'S DISEASE | |
EP1673078A4 (en) | BENZYL ETHER AND BENZYLAMINO BETA SEKRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER DISEASE | |
EA200870569A1 (ru) | Соединения и способы модуляции fxr | |
EA200700489A1 (ru) | Новые бензоконденсированные гетероарилсульфамидные производные, полезные в качестве противоконвульсивных средств | |
NZ596579A (en) | Bace inhibitors | |
WO2005004802A3 (en) | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease | |
EA200901373A1 (ru) | Аминогетероциклические соединения | |
TW200728305A (en) | Spiropiperidine beta-sectetase inhibitors for the treatment of alzheimer's disease | |
WO2005004803A3 (en) | Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease | |
EA200401114A3 (ru) | Замещённые гидроксиэтиламины | |
EA200900152A1 (ru) | Ингибиторы пирролотриазинкиназы | |
WO2006078576A3 (en) | Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease | |
ATE538651T1 (de) | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
WO2005090296A3 (en) | N-substituted benzene sulfonamides | |
WO2005051914A8 (en) | Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease | |
EA200800880A1 (ru) | Комбинация росиглитазона и донепезила, предназначенная для улучшения когнитивной функции | |
EA200870577A1 (ru) | Конденсированные трициклические сульфонамидные ингибиторы гамма-секретазы | |
WO2006055434A3 (en) | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease | |
EP1817312A4 (en) | MACROCYCLIC AMINIOPYRIDYL BETA SEKRETASE INHIBITORS FOR THE TREATMENT OF MORBUS ALZHEIMER | |
WO2007058862A3 (en) | Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
ATE389395T1 (de) | Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson | |
EA200801302A1 (ru) | Композиции и способы лечения нарушений цнс | |
EA200601607A1 (ru) | Сульфонамидные соединения для лечения нейродегенеративных расстройств | |
NO20076405L (no) | Anvendelse av 24-nor-UDCA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |