NO20085323L - Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase - Google Patents

Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase

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Publication number
NO20085323L
NO20085323L NO20085323A NO20085323A NO20085323L NO 20085323 L NO20085323 L NO 20085323L NO 20085323 A NO20085323 A NO 20085323A NO 20085323 A NO20085323 A NO 20085323A NO 20085323 L NO20085323 L NO 20085323L
Authority
NO
Norway
Prior art keywords
melted
compounds
formula
gamma secretase
sulfonamide inhibitors
Prior art date
Application number
NO20085323A
Other languages
English (en)
Inventor
Andrei W Konradi
Gary Probst
Danielle L Aubele
Albert W Garofalo
Roy Hom
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO20085323L publication Critical patent/NO20085323L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)

Abstract

Oppfinnelsen tilveiebringer forbindelser med formel I: eller farmasøytisk akseptable salter derav, hvor Ri, R2 og A-, B- og C-ringene er som definert heri. Forbindelser med formel I er anvendelige ved behandling eller hindring av kognitive forstyrrelser, slik som Alzheimer's sykdom. Oppfinnelsen omfatter også farmasøytiske sammensetninger som innbefatter forbindelser og salter med formel I, fremgangsmåter for fremstilling av de ønskede forbindelsene, og fremgangsmåter for behandling av kognitive forstyrrelser slik som Alzheimer's sykdom, ved anvendelse av forbindelsene eller saltene med formel I.
NO20085323A 2006-06-02 2008-12-19 Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase NO20085323L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81043106P 2006-06-02 2006-06-02
US87693206P 2006-12-22 2006-12-22
US92277107P 2007-04-10 2007-04-10
PCT/US2007/070176 WO2007143523A2 (en) 2006-06-02 2007-06-01 Fused, tricyclic sulfonamide inhibitors of gamma secretase

Publications (1)

Publication Number Publication Date
NO20085323L true NO20085323L (no) 2009-02-24

Family

ID=38686795

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085323A NO20085323L (no) 2006-06-02 2008-12-19 Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase

Country Status (22)

Country Link
US (1) US20080021056A1 (no)
EP (2) EP2450358A1 (no)
JP (1) JP2009539773A (no)
KR (1) KR20090015159A (no)
CN (2) CN102850349A (no)
AR (1) AR061161A1 (no)
AU (1) AU2007256860A1 (no)
BR (1) BRPI0712123A2 (no)
CA (1) CA2651550A1 (no)
EA (1) EA200870577A1 (no)
EC (1) ECSP089019A (no)
IL (1) IL195078A0 (no)
MA (1) MA30532B1 (no)
MX (1) MX2008014947A (no)
MY (1) MY169274A (no)
NO (1) NO20085323L (no)
NZ (1) NZ572885A (no)
PE (1) PE20080988A1 (no)
SG (1) SG172629A1 (no)
TW (1) TW200813054A (no)
UY (1) UY30377A1 (no)
WO (1) WO2007143523A2 (no)

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EP1976843B1 (en) 2006-01-20 2013-09-04 Merck Sharp & Dohme Corp. Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
BRPI0812014A2 (pt) 2007-05-25 2014-11-18 Elan Pharm Inc Pirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos
BRPI0814256A8 (pt) * 2007-07-05 2016-02-10 Schering Corp Inibidores de tetrahidropiranocromeno gama secretase
CN101970445A (zh) * 2007-07-17 2011-02-09 先灵公司 苯磺酰基-色满、硫代色满、四氢萘和相关γ分泌酶抑制剂
CN102203089A (zh) * 2008-09-05 2011-09-28 伊兰医药品公司 N-磺酰氨基多环吡唑基化合物
AU2010229954A1 (en) * 2009-03-25 2011-10-06 Elan Pharmaceuticals, Inc. Process for the production of fused, tricyclic sulfonamides
WO2010123716A1 (en) * 2009-04-20 2010-10-28 Merck Sharp & Dohme Corp. Heterocyclic fused cinnoline m1 receptor positive allosteric modulators
US9023767B2 (en) * 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
CN103502466A (zh) 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
US10319527B2 (en) * 2017-04-04 2019-06-11 Samsung Electro-Mechanics Co., Ltd. Multilayer capacitor
CN110526913B (zh) * 2019-08-30 2022-04-29 中国药科大学 一种抗凝药物阿哌沙班相关物质的制备方法
CN114853707B (zh) * 2022-06-13 2024-01-26 上饶师范学院 一种合成二氟氢甲基化2,3-二氢苯并吡喃-4-酮衍生物的方法

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US4666829A (en) 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
US5766846A (en) 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
JPH0977752A (ja) * 1995-09-12 1997-03-25 Kao Corp Ｎ−無置換イソオキサゾリジンの製造法
GB9720899D0 (en) * 1997-10-01 1997-12-03 Pharmacia & Upjohn Spa Condensed heterocyclic compounds
PL372212A1 (en) * 2001-08-03 2005-07-11 Schering Corporation Novel gamma secretase inhibitors
DE60220422T2 (de) * 2001-09-19 2008-02-07 Pharmacia Corp. Substituierte pyrazol-verbindungen zur behandlung von entzündungen
JP2006151810A (ja) * 2002-12-26 2006-06-15 Daiichi Asubio Pharma Co Ltd ジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤
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WO2005113542A2 (en) * 2004-05-20 2005-12-01 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
WO2006068928A1 (en) * 2004-12-20 2006-06-29 Wyeth Pyrrolo[1,2-a]quinoxalin-5-(4h)-yl)sulfonyls and carbonyls and their use as estrogenic agents

Also Published As

Publication number Publication date
WO2007143523A8 (en) 2008-01-31
BRPI0712123A2 (pt) 2012-07-10
MX2008014947A (es) 2008-12-10
US20080021056A1 (en) 2008-01-24
JP2009539773A (ja) 2009-11-19
WO2007143523A2 (en) 2007-12-13
CN101501032B (zh) 2012-10-10
NZ572885A (en) 2012-02-24
MA30532B1 (fr) 2009-06-01
UY30377A1 (es) 2008-01-02
SG172629A1 (en) 2011-07-28
KR20090015159A (ko) 2009-02-11
CN101501032A (zh) 2009-08-05
EP2038280A2 (en) 2009-03-25
EP2450358A1 (en) 2012-05-09
WO2007143523A3 (en) 2008-06-12
IL195078A0 (en) 2009-08-03
CA2651550A1 (en) 2007-12-13
EA200870577A1 (ru) 2009-06-30
AU2007256860A1 (en) 2007-12-13
CN102850349A (zh) 2013-01-02
AR061161A1 (es) 2008-08-06
MY169274A (en) 2019-03-21
PE20080988A1 (es) 2008-08-15
TW200813054A (en) 2008-03-16
ECSP089019A (es) 2009-02-27

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