ATE523511T1 - Pyrazolopyrrolidine als inhibitoren von gamma- sekretase - Google Patents

Pyrazolopyrrolidine als inhibitoren von gamma- sekretase

Info

Publication number
ATE523511T1
ATE523511T1 AT08756023T AT08756023T ATE523511T1 AT E523511 T1 ATE523511 T1 AT E523511T1 AT 08756023 T AT08756023 T AT 08756023T AT 08756023 T AT08756023 T AT 08756023T AT E523511 T1 ATE523511 T1 AT E523511T1
Authority
AT
Austria
Prior art keywords
pyrazolopyrrolidines
inhibitors
gamma secretase
secretase
gamma
Prior art date
Application number
AT08756023T
Other languages
English (en)
Inventor
Darren Dressen
Simeon Bowers
Albert Garofalo
Roy Hom
Matthew Mattson
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Application granted granted Critical
Publication of ATE523511T1 publication Critical patent/ATE523511T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08756023T 2007-05-25 2008-05-21 Pyrazolopyrrolidine als inhibitoren von gamma- sekretase ATE523511T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93184007P 2007-05-25 2007-05-25
PCT/US2008/064324 WO2008147800A1 (en) 2007-05-25 2008-05-21 Pyrazolopyrrolidines as inhibitors of gamma secretase

Publications (1)

Publication Number Publication Date
ATE523511T1 true ATE523511T1 (de) 2011-09-15

Family

ID=39679310

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08756023T ATE523511T1 (de) 2007-05-25 2008-05-21 Pyrazolopyrrolidine als inhibitoren von gamma- sekretase

Country Status (17)

Country Link
US (1) US7977368B2 (de)
EP (1) EP2152713B1 (de)
JP (1) JP2010528036A (de)
AR (1) AR066712A1 (de)
AT (1) ATE523511T1 (de)
AU (1) AU2008256940A1 (de)
BR (1) BRPI0812014A2 (de)
CA (1) CA2687765A1 (de)
CL (1) CL2008001516A1 (de)
CO (1) CO6241122A2 (de)
ES (1) ES2373253T3 (de)
MX (1) MX2009012525A (de)
NZ (1) NZ582039A (de)
PE (1) PE20090280A1 (de)
TW (1) TW200904413A (de)
WO (1) WO2008147800A1 (de)
ZA (1) ZA200908919B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201170421A1 (ru) * 2008-09-05 2012-01-30 Элан Фармасьютикалз, Инк. N-сульфонамидопиразолильные полициклические соединения
CN106518769A (zh) * 2009-08-03 2017-03-22 方济各安吉利克化学联合股份有限公司 1‑苄基‑3‑羟甲基‑1h‑吲唑及其衍生物以及所需镁中间体的制备方法
US8486940B2 (en) 2009-09-11 2013-07-16 Probiodrug Ag Inhibitors
US8518945B2 (en) 2010-03-22 2013-08-27 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
US8481541B2 (en) 2010-03-22 2013-07-09 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
BR112012029437A2 (pt) 2010-05-20 2017-03-07 F Hoffmann - La Roche Ag derivados de pirrolo[2,3-b]pirazina-7-carboxamida e seu uso como inibidores de jak e syk
EP2571881A1 (de) 2010-05-20 2013-03-27 F.Hoffmann-La Roche Ag Pyrrolopyrazinderivate als syk- und jak-hemmer
JP6644017B2 (ja) * 2017-03-30 2020-02-12 長弘生物科技股▲ふん▼有限公司 ブチリデンフタリドの用途、その使用方法及びそれを使用して医薬組成物を製造する方法
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999033785A1 (en) * 1997-12-27 1999-07-08 Kaneka Corporation PROCESSES FOR PRODUCING β-HALOGENO-α-AMINO-CARBOXYLIC ACIDS AND PHENYLCYSTEINE DERIVATIVES AND INTERMEDIATES THEREOF
US6887898B1 (en) * 1999-10-22 2005-05-03 Darrick S. H. L. Kim Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
US6559174B2 (en) 2001-03-20 2003-05-06 Merck & Co., Inc. N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
US20040171614A1 (en) * 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
US7256186B2 (en) 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
BR0312924A (pt) * 2002-07-25 2005-07-12 Pharmacia Italia Spa Biciclo-pirazóis ativos como inibidores de quinase, processo para sua preparação e composições farmacêuticas compreendendo os mesmos
US20060264380A1 (en) 2003-07-21 2006-11-23 Mats Hellstrom Compounds and Methods for Promoting Angiogenesis
CA2539549A1 (en) 2003-09-23 2005-04-07 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
EP1915371A4 (de) 2005-08-19 2010-09-15 Elan Pharm Inc Verbrückte n-bicyclische sulfonamid-hemmer der gammasekretase
TW200736255A (en) * 2005-12-01 2007-10-01 Elan Pharm Inc 5-(Substituted)-pyrazolopiperidines
UY30377A1 (es) 2006-06-02 2008-01-02 Elan Pharm Inc Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa

Also Published As

Publication number Publication date
CA2687765A1 (en) 2008-12-04
EP2152713A1 (de) 2010-02-17
AR066712A1 (es) 2009-09-09
CO6241122A2 (es) 2011-01-20
AU2008256940A1 (en) 2008-12-04
ES2373253T3 (es) 2012-02-01
EP2152713B1 (de) 2011-09-07
CL2008001516A1 (es) 2008-10-10
PE20090280A1 (es) 2009-03-19
ZA200908919B (en) 2010-08-25
MX2009012525A (es) 2009-12-09
TW200904413A (en) 2009-02-01
BRPI0812014A2 (pt) 2014-11-18
US20090099235A1 (en) 2009-04-16
US7977368B2 (en) 2011-07-12
NZ582039A (en) 2012-02-24
JP2010528036A (ja) 2010-08-19
WO2008147800A1 (en) 2008-12-04

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties