JP6644017B2 - ブチリデンフタリドの用途、その使用方法及びそれを使用して医薬組成物を製造する方法 - Google Patents
ブチリデンフタリドの用途、その使用方法及びそれを使用して医薬組成物を製造する方法 Download PDFInfo
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- 230000019491 signal transduction Effects 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
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- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000023895 stem cell maintenance Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 102000013498 tau Proteins Human genes 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Description
(I)であり、その製造又は入手方式が当業者の常識であり、且つ本発明の技術的特徴ではないことから、本発明では詳細な説明を省略する。例えば、中国特許出願第200910066666号には、有機溶剤を使用してセリ科又はキク科植物からブチリデンフタリドを抽出することが開示され、中国特許公告第1041725C号には、チリデンフタリドを化学合成方式により合成することが開示されている。
(II)(式中、x、y、zはそれぞれ1より大きい整数である。)である。高分子物質F127の両端におけるポリオキシエチレンが親水性を有し、中部におけるポリオキシプロピレンが疎水性であるため、高分子物質F127は両性物質になる。高分子物質F127は、水溶液に存在する場合に、徐々に界面へ拡散して界面に吸着して、表面張力を低下させ、且つ、高分子物質内における親水基と疎水基の比率を制御することによって、高分子物質の表面活性を制御できる。
Claims (3)
- β-アミロイドタンパク質の濃度を低減するための医薬組成物の製造におけるブチリデンフタリドの使用であって、
前記医薬組成物が高分子物質であるF127をさらに含み、前記ブチリデンフタリドがF127で被覆される、使用。 - 前記医薬組成物がアルツハイマー病を治療及び/又は予防するための請求項1に記載の使用。
- 前記ブチリデンフタリドが化学合成技術により製造される請求項1に記載の使用。
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