BRPI0814256A2 - Inibidores de tetrahidropiranocromeno gama secretase - Google Patents
Inibidores de tetrahidropiranocromeno gama secretaseInfo
- Publication number
- BRPI0814256A2 BRPI0814256A2 BRPI0814256-4A2A BRPI0814256A BRPI0814256A2 BR PI0814256 A2 BRPI0814256 A2 BR PI0814256A2 BR PI0814256 A BRPI0814256 A BR PI0814256A BR PI0814256 A2 BRPI0814256 A2 BR PI0814256A2
- Authority
- BR
- Brazil
- Prior art keywords
- tetrahydropyrochyromene
- secretase
- inhibitors
- range
- range inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94803307P | 2007-07-05 | 2007-07-05 | |
PCT/US2008/008192 WO2009008980A2 (en) | 2007-07-05 | 2008-07-01 | Tetrahydropyranochromene gamma secretase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0814256A2 true BRPI0814256A2 (pt) | 2015-02-03 |
BRPI0814256A8 BRPI0814256A8 (pt) | 2016-02-10 |
Family
ID=39830164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0814256A BRPI0814256A8 (pt) | 2007-07-05 | 2008-07-01 | Inibidores de tetrahidropiranocromeno gama secretase |
Country Status (16)
Country | Link |
---|---|
US (1) | US8664411B2 (pt) |
EP (1) | EP2435416B1 (pt) |
JP (1) | JP5240871B2 (pt) |
KR (1) | KR20100044197A (pt) |
CN (1) | CN101754960A (pt) |
AR (1) | AR067445A1 (pt) |
AU (1) | AU2008275735B2 (pt) |
BR (1) | BRPI0814256A8 (pt) |
CA (1) | CA2691542A1 (pt) |
CL (1) | CL2008001960A1 (pt) |
CO (1) | CO6270309A2 (pt) |
EC (1) | ECSP109845A (pt) |
PE (1) | PE20090435A1 (pt) |
RU (1) | RU2483061C2 (pt) |
TW (1) | TW200908959A (pt) |
WO (1) | WO2009008980A2 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080095885A (ko) | 2006-01-20 | 2008-10-29 | 쉐링 코포레이션 | 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제 |
WO2009011851A1 (en) | 2007-07-17 | 2009-01-22 | Schering Corporation | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
KR101755737B1 (ko) | 2009-09-11 | 2017-07-07 | 프로비오드룩 아게 | 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 |
WO2012040444A2 (en) * | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Treatment of patients with incipient alzheimer's disease |
US8933116B2 (en) | 2011-04-04 | 2015-01-13 | Merck Sharp & Dohme Corp. | Gamma secretase inhibitors |
EP2753623A4 (en) * | 2011-09-09 | 2015-01-28 | Merck Sharp & Dohme | GAMMA SECRETASE INHIBITORS |
US9464103B2 (en) | 2012-11-29 | 2016-10-11 | Merck Sharp & Dohme Corp. | Spirocyclic sulfones as gamma secretase inhibitors |
CN104918938B (zh) * | 2012-12-20 | 2017-08-15 | 詹森药业有限公司 | 新颖的作为γ分泌酶调节剂的三环3,4‑二氢‑2H‑吡啶并[1,2‑a]吡嗪‑1,6‑二酮衍生物 |
WO2014111457A1 (en) | 2013-01-17 | 2014-07-24 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
AU2017356911A1 (en) | 2016-11-09 | 2019-06-20 | Bristol-Myers Squibb Company | Tricyclic sulfones as ROR gamma modulators |
CA3066077A1 (en) | 2017-06-07 | 2018-12-13 | Adrx, Inc. | Tau aggregation inhibitors |
CA3073062A1 (en) | 2017-08-18 | 2019-02-21 | Adrx, Inc. | Tau aggregation peptide inhibitors |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020006626A (ko) | 1999-02-26 | 2002-01-23 | 폴락 돈나 엘. | 신규한 술폰아미드 화합물 및 그의 용도 |
FR2827590B1 (fr) * | 2001-07-18 | 2003-10-24 | Atuser | Transbordeur de liquides alimentaires usages |
GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
AU2002324582B9 (en) * | 2001-08-03 | 2006-02-16 | Schering Corporation | Novel gamma secretase inhibitors |
RU2202370C1 (ru) * | 2001-12-26 | 2003-04-20 | Эпштейн Олег Ильич | Нейропсихотропное лекарственное средство |
GB0222833D0 (en) | 2002-10-02 | 2002-11-06 | Syngenta Ltd | Chemical process |
GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
US7410964B2 (en) * | 2003-05-16 | 2008-08-12 | Merck Sharp & Dohme Ltd. | Cyclohexyl sulphones as gamma-secretase inhibitors |
GB0317491D0 (en) * | 2003-07-25 | 2003-08-27 | Novartis Ag | Organic compounds |
DE102005062098A1 (de) * | 2005-12-22 | 2007-06-28 | Merck Patent Gmbh | Oxaphenanthren-Derivate |
KR20080095885A (ko) * | 2006-01-20 | 2008-10-29 | 쉐링 코포레이션 | 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제 |
TW200813054A (en) * | 2006-06-02 | 2008-03-16 | Elan Pharm Inc | Fused, tricyclic sulfonamide inhibitors of gamma secretase |
CA2742486A1 (en) | 2008-11-13 | 2010-05-20 | Schering Corporation | Gamma secretase modulators |
-
2008
- 2008-07-01 KR KR1020107002496A patent/KR20100044197A/ko not_active Application Discontinuation
- 2008-07-01 WO PCT/US2008/008192 patent/WO2009008980A2/en active Application Filing
- 2008-07-01 RU RU2010103716/04A patent/RU2483061C2/ru not_active IP Right Cessation
- 2008-07-01 US US12/665,580 patent/US8664411B2/en active Active
- 2008-07-01 JP JP2010514862A patent/JP5240871B2/ja not_active Expired - Fee Related
- 2008-07-01 CN CN200880023464A patent/CN101754960A/zh active Pending
- 2008-07-01 CA CA002691542A patent/CA2691542A1/en not_active Abandoned
- 2008-07-01 AU AU2008275735A patent/AU2008275735B2/en not_active Ceased
- 2008-07-01 EP EP08768856.0A patent/EP2435416B1/en active Active
- 2008-07-01 BR BRPI0814256A patent/BRPI0814256A8/pt not_active IP Right Cessation
- 2008-07-02 AR ARP080102867A patent/AR067445A1/es not_active Application Discontinuation
- 2008-07-02 CL CL2008001960A patent/CL2008001960A1/es unknown
- 2008-07-02 PE PE2008001121A patent/PE20090435A1/es not_active Application Discontinuation
- 2008-07-02 TW TW097124900A patent/TW200908959A/zh unknown
-
2009
- 2009-12-30 CO CO09149364A patent/CO6270309A2/es not_active Application Discontinuation
-
2010
- 2010-01-05 EC EC2010009845A patent/ECSP109845A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP5240871B2 (ja) | 2013-07-17 |
AU2008275735B2 (en) | 2014-03-27 |
RU2483061C2 (ru) | 2013-05-27 |
WO2009008980A2 (en) | 2009-01-15 |
BRPI0814256A8 (pt) | 2016-02-10 |
AR067445A1 (es) | 2009-10-14 |
AU2008275735A1 (en) | 2009-01-15 |
KR20100044197A (ko) | 2010-04-29 |
WO2009008980A3 (en) | 2009-03-19 |
CL2008001960A1 (es) | 2009-11-27 |
US8664411B2 (en) | 2014-03-04 |
RU2010103716A (ru) | 2011-08-10 |
EP2435416A2 (en) | 2012-04-04 |
AU2008275735A2 (en) | 2010-02-11 |
EP2435416B1 (en) | 2016-03-30 |
CO6270309A2 (es) | 2011-04-20 |
ECSP109845A (es) | 2010-02-26 |
CA2691542A1 (en) | 2009-01-15 |
TW200908959A (en) | 2009-03-01 |
PE20090435A1 (es) | 2009-04-18 |
CN101754960A (zh) | 2010-06-23 |
JP2010532359A (ja) | 2010-10-07 |
US20110236400A1 (en) | 2011-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B25D | Requested change of name of applicant approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
|
B25G | Requested change of headquarter approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |