ECSP109845A - Inhibidores tetrahidropiranocromeno de gamma secretasa - Google Patents
Inhibidores tetrahidropiranocromeno de gamma secretasaInfo
- Publication number
- ECSP109845A ECSP109845A EC2010009845A ECSP109845A ECSP109845A EC SP109845 A ECSP109845 A EC SP109845A EC 2010009845 A EC2010009845 A EC 2010009845A EC SP109845 A ECSP109845 A EC SP109845A EC SP109845 A ECSP109845 A EC SP109845A
- Authority
- EC
- Ecuador
- Prior art keywords
- tertiary amine
- gamma secretase
- basic tertiary
- heteroaryl
- basic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen nuevos inhibidores de gamma secretasa de la fórmula: .También se describen métodos de inhibir la gamma-secretasa, métodos de tratar enfermedades neurodegenerativas, y métodos de tratar enfermedad de Alzheimer. También se describen procesos para preparar alquenos en un paso de reacción usando una mezcla de un aldehído (o cetona) y un alquilo sustituido con dos grupos atrayentes de electrones y la reacción de la mezcla con: (a) un haluro de sulfonilo (por ej., un cloruro de sulfonilo) y una amina terciaria básica, o, (b) un anhídrido de sulfonilo y una amina básica, o (c) un aril-C(O)-haluro y una amina terciaria básica, o (d) un aril-C(O)-O-C(O)-arilo y una amina terciaria básica, o (e) un heteroaril-C(O)-haluro y una amina terciaria básica, o (f) un heteroaril-C(O)-O-C(O)-heteroarilo y una amina terciaria básica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94803307P | 2007-07-05 | 2007-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP109845A true ECSP109845A (es) | 2010-02-26 |
Family
ID=39830164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010009845A ECSP109845A (es) | 2007-07-05 | 2010-01-05 | Inhibidores tetrahidropiranocromeno de gamma secretasa |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8664411B2 (es) |
| EP (1) | EP2435416B1 (es) |
| JP (1) | JP5240871B2 (es) |
| KR (1) | KR20100044197A (es) |
| CN (1) | CN101754960A (es) |
| AR (1) | AR067445A1 (es) |
| AU (1) | AU2008275735B2 (es) |
| BR (1) | BRPI0814256A8 (es) |
| CA (1) | CA2691542A1 (es) |
| CL (1) | CL2008001960A1 (es) |
| CO (1) | CO6270309A2 (es) |
| EC (1) | ECSP109845A (es) |
| PE (1) | PE20090435A1 (es) |
| RU (1) | RU2483061C2 (es) |
| TW (1) | TW200908959A (es) |
| WO (1) | WO2009008980A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20071321A1 (es) | 2006-01-20 | 2007-12-29 | Schering Corp | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados |
| US8618123B2 (en) * | 2007-07-17 | 2013-12-31 | Merck Sharp & Dohme Corp. | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| WO2012040444A2 (en) * | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Treatment of patients with incipient alzheimer's disease |
| EP2693880A1 (en) * | 2011-04-04 | 2014-02-12 | Merck Sharp & Dohme Corp. | Gamma secretase inhibitors |
| WO2013036464A1 (en) * | 2011-09-09 | 2013-03-14 | Merck Sharp & Dohme Corp. | Gamma secretase inhibitors |
| US9464103B2 (en) | 2012-11-29 | 2016-10-11 | Merck Sharp & Dohme Corp. | Spirocyclic sulfones as gamma secretase inhibitors |
| KR102209418B1 (ko) | 2012-12-20 | 2021-01-29 | 얀센 파마슈티카 엔.브이. | 감마 세크레타제 조절 인자로서의 신규 삼환 3,4-디하이드로-2H-피리도[1,2-α]피라진-1,6-디온 유도체 |
| US10246454B2 (en) | 2013-01-17 | 2019-04-02 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| TW201821404A (zh) * | 2016-11-09 | 2018-06-16 | 美商必治妥美雅史谷比公司 | 作為ROR γ調節劑之三環碸 |
| WO2018226992A1 (en) | 2017-06-07 | 2018-12-13 | Adrx, Inc. | Tau aggregation inhibitors |
| US11453701B2 (en) | 2017-08-18 | 2022-09-27 | Adrx, Inc. | Tau aggregation peptide inhibitors |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU773273B2 (en) | 1999-02-26 | 2004-05-20 | Bristol-Myers Squibb Company | Novel sulfonamide compounds and uses thereof |
| FR2827590B1 (fr) * | 2001-07-18 | 2003-10-24 | Atuser | Transbordeur de liquides alimentaires usages |
| GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| WO2003014075A2 (en) | 2001-08-03 | 2003-02-20 | Schering Corporation | Novel gamma secretase inhibitors |
| RU2202370C1 (ru) * | 2001-12-26 | 2003-04-20 | Эпштейн Олег Ильич | Нейропсихотропное лекарственное средство |
| GB0222833D0 (en) | 2002-10-02 | 2002-11-06 | Syngenta Ltd | Chemical process |
| GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| JP4818114B2 (ja) | 2003-05-16 | 2011-11-16 | メルク シャープ エンド ドーム リミテッド | γ−セクレターゼ阻害剤としてのシクロヘキシルスルホン類 |
| GB0317491D0 (en) * | 2003-07-25 | 2003-08-27 | Novartis Ag | Organic compounds |
| DE102005062098A1 (de) * | 2005-12-22 | 2007-06-28 | Merck Patent Gmbh | Oxaphenanthren-Derivate |
| PE20071321A1 (es) * | 2006-01-20 | 2007-12-29 | Schering Corp | Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados |
| TW200813054A (en) | 2006-06-02 | 2008-03-16 | Elan Pharm Inc | Fused, tricyclic sulfonamide inhibitors of gamma secretase |
| WO2010056849A1 (en) | 2008-11-13 | 2010-05-20 | Schering Corporation | Gamma secretase modulators |
-
2008
- 2008-07-01 WO PCT/US2008/008192 patent/WO2009008980A2/en active Application Filing
- 2008-07-01 AU AU2008275735A patent/AU2008275735B2/en not_active Ceased
- 2008-07-01 JP JP2010514862A patent/JP5240871B2/ja not_active Expired - Fee Related
- 2008-07-01 US US12/665,580 patent/US8664411B2/en active Active
- 2008-07-01 KR KR1020107002496A patent/KR20100044197A/ko not_active Application Discontinuation
- 2008-07-01 BR BRPI0814256A patent/BRPI0814256A8/pt not_active IP Right Cessation
- 2008-07-01 RU RU2010103716/04A patent/RU2483061C2/ru not_active IP Right Cessation
- 2008-07-01 EP EP08768856.0A patent/EP2435416B1/en active Active
- 2008-07-01 CN CN200880023464A patent/CN101754960A/zh active Pending
- 2008-07-01 CA CA002691542A patent/CA2691542A1/en not_active Abandoned
- 2008-07-02 TW TW097124900A patent/TW200908959A/zh unknown
- 2008-07-02 AR ARP080102867A patent/AR067445A1/es not_active Application Discontinuation
- 2008-07-02 PE PE2008001121A patent/PE20090435A1/es not_active Application Discontinuation
- 2008-07-02 CL CL2008001960A patent/CL2008001960A1/es unknown
-
2009
- 2009-12-30 CO CO09149364A patent/CO6270309A2/es not_active Application Discontinuation
-
2010
- 2010-01-05 EC EC2010009845A patent/ECSP109845A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR067445A1 (es) | 2009-10-14 |
| RU2010103716A (ru) | 2011-08-10 |
| AU2008275735A2 (en) | 2010-02-11 |
| US20110236400A1 (en) | 2011-09-29 |
| WO2009008980A2 (en) | 2009-01-15 |
| US8664411B2 (en) | 2014-03-04 |
| WO2009008980A3 (en) | 2009-03-19 |
| EP2435416B1 (en) | 2016-03-30 |
| BRPI0814256A8 (pt) | 2016-02-10 |
| CA2691542A1 (en) | 2009-01-15 |
| AU2008275735A1 (en) | 2009-01-15 |
| RU2483061C2 (ru) | 2013-05-27 |
| TW200908959A (en) | 2009-03-01 |
| CN101754960A (zh) | 2010-06-23 |
| BRPI0814256A2 (pt) | 2015-02-03 |
| KR20100044197A (ko) | 2010-04-29 |
| CL2008001960A1 (es) | 2009-11-27 |
| JP2010532359A (ja) | 2010-10-07 |
| JP5240871B2 (ja) | 2013-07-17 |
| AU2008275735B2 (en) | 2014-03-27 |
| CO6270309A2 (es) | 2011-04-20 |
| EP2435416A2 (en) | 2012-04-04 |
| PE20090435A1 (es) | 2009-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP109845A (es) | Inhibidores tetrahidropiranocromeno de gamma secretasa | |
| NO2023022I1 (no) | cobimetinib, optionally in any form protected by the basic patent, including harmaceutically acceptable salts and sovates thereof, particularly cobimetinib hemifumarate | |
| MX2018009633A (es) | Inhibidor de indoleamina-2,3-dioxigenasa (ido). | |
| BRPI0712631B8 (pt) | compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações | |
| EA200900959A1 (ru) | Ингибиторы мек | |
| BRPI0606524A2 (pt) | derivados de indol para o tratamento de infecções virais | |
| CY1110214T1 (el) | Μεθοδοι και ενδιαμεσα | |
| DK1853602T3 (da) | Kemiske forbindelser | |
| DK1853588T3 (da) | Kemiske forbindelser | |
| BRPI0821994B8 (pt) | composto ou um enantiômero, um diasteroisômero ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto | |
| BR0305258A (pt) | Inibidores de polimerase de ns5b de hcv | |
| BRPI0815920A2 (pt) | Composto, composição farmacêutica, e, uso do composto. | |
| CR11483A (es) | Inhibidores de peptido desformilasa | |
| ATE496914T1 (de) | Verfahren zur synthese von triazolen | |
| BRPI0408353A (pt) | composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto | |
| BRPI0416287A (pt) | compostos, processo para a manufatura dos mesmos, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que são moduladas por inibidores de accß e sua utilização | |
| BR112022000782A2 (pt) | Composto, composição farmacêutica, processo para preparar um composto, composto intermediário, e, uso de um composto, ou de um sal farmaceuticamente aceitável ou solvato do mesmo, ou de uma composição farmacêutica | |
| NO20091495L (no) | Pyrazolopyrimidinderivat | |
| DE60322852D1 (de) | Verfahren zur herstellung von eplerenon | |
| DE502007003531D1 (de) | Verfahren zum herstellen von alkylaniliden aus halogenbenzolderivaten | |
| BRPI0720835A2 (pt) | processo para preparação de 3,5-di-omicron-acil-2-fluoro-2-c-metil-d-ribono-gama-lactona | |
| ATE540026T1 (de) | Hydroxyphenylsulfonsäureamide als antiapoptotische bcl-inhibitoren | |
| BR112021018254A8 (pt) | Derivados de nicorandil | |
| EA200600560A1 (ru) | Ингибиторы проникновения вируса вич | |
| BRPI0411921A (pt) | processo para preparar intermediários úteis para preparar determinadas hidroxilaminas de n-formila antibacterianas |