BRPI0921348A2 - moduladores heterocíclicos da gama secretase - Google Patents
moduladores heterocíclicos da gama secretaseInfo
- Publication number
- BRPI0921348A2 BRPI0921348A2 BRPI0921348A BRPI0921348A BRPI0921348A2 BR PI0921348 A2 BRPI0921348 A2 BR PI0921348A2 BR PI0921348 A BRPI0921348 A BR PI0921348A BR PI0921348 A BRPI0921348 A BR PI0921348A BR PI0921348 A2 BRPI0921348 A2 BR PI0921348A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclic
- gamma secretase
- secretase modulators
- modulators
- gamma
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168719 | 2008-11-10 | ||
| PCT/EP2009/064497 WO2010052199A1 (en) | 2008-11-10 | 2009-11-03 | Heterocyclic gamma secretase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0921348A2 true BRPI0921348A2 (pt) | 2019-09-24 |
Family
ID=41728178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921348A BRPI0921348A2 (pt) | 2008-11-10 | 2009-11-03 | moduladores heterocíclicos da gama secretase |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8288403B2 (pt) |
| EP (1) | EP2355817A1 (pt) |
| JP (1) | JP5378532B2 (pt) |
| KR (1) | KR101293421B1 (pt) |
| CN (1) | CN102209537A (pt) |
| AR (1) | AR074304A1 (pt) |
| AU (1) | AU2009312856A1 (pt) |
| BR (1) | BRPI0921348A2 (pt) |
| CA (1) | CA2743196A1 (pt) |
| IL (1) | IL212497A0 (pt) |
| MX (1) | MX2011004954A (pt) |
| TW (1) | TW201021795A (pt) |
| WO (1) | WO2010052199A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110113197A (ko) | 2009-02-06 | 2011-10-14 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물 |
| EP2427453B1 (en) | 2009-05-07 | 2013-07-17 | Janssen Pharmaceuticals, Inc. | Substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| CN102482227A (zh) | 2009-07-15 | 2012-05-30 | 杨森制药公司 | 作为γ分泌酶调节剂的取代的三唑和咪唑衍生物 |
| BR112012017442A2 (pt) * | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol bicíclicos substituídos como moduladores de gamma secretase |
| AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| CA2830027C (en) | 2011-03-31 | 2016-04-26 | Pfizer Inc. | Novel bicyclic pyridinones |
| CN103874702B (zh) | 2011-07-15 | 2015-12-09 | 杨森制药公司 | 作为γ分泌酶调节剂的经取代的吲哚衍生物 |
| BR112014028395B1 (pt) | 2012-05-16 | 2022-02-01 | Janssen Pharmaceuticals, Inc. | Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| AU2013366668B2 (en) | 2012-12-20 | 2017-07-20 | Janssen Pharmaceutica Nv | Novel tricyclic 3,4-dihydro-2H-pyrido[1,2-alpha]pyrazine -1,6-dione derivatives as gamma secretase modulators |
| KR102171710B1 (ko) | 2013-01-17 | 2020-10-30 | 얀센 파마슈티카 엔.브이. | 감마 세크레타제 조절 인자로서의 신규 치환 피리도-피페라지논 유도체 |
| ES2701810T3 (es) | 2013-06-04 | 2019-02-26 | Acturum Real Estate Ab | Compuestos de triazol y su uso como moduladores de gamma-secretasa |
| WO2014195323A1 (en) | 2013-06-04 | 2014-12-11 | Acturum Life Science AB | Pyrimidine compounds and their use as gamma secretase modulators |
| EP3004081B1 (en) | 2013-06-04 | 2017-11-15 | Acturum Real Estate AB | Triazole compounds and their use as gamma secretase modulators |
| JP6532646B2 (ja) * | 2013-12-06 | 2019-06-19 | ロレアル | パウダー状化粧用組成物 |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| CN107406445B (zh) | 2015-02-03 | 2019-12-24 | 辉瑞公司 | 新颖环丙苯并呋喃基吡啶并吡嗪二酮类 |
| KR101719419B1 (ko) * | 2015-08-05 | 2017-03-23 | 건국대학교 산학협력단 | 베타 아밀로이드의 올리고화 및 섬유화 저해능과 함께 신경세포 보호능력을 갖는 신규 알츠하이머병 치료제 |
| WO2017042114A1 (en) * | 2015-09-09 | 2017-03-16 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| WO2018106646A1 (en) * | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018130555A1 (en) * | 2017-01-12 | 2018-07-19 | Vib Vzw | Gamma-secretase stabilizing compound screening assay |
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-
2009
- 2009-11-03 KR KR1020117013192A patent/KR101293421B1/ko not_active IP Right Cessation
- 2009-11-03 AU AU2009312856A patent/AU2009312856A1/en not_active Abandoned
- 2009-11-03 CN CN2009801446341A patent/CN102209537A/zh active Pending
- 2009-11-03 BR BRPI0921348A patent/BRPI0921348A2/pt not_active IP Right Cessation
- 2009-11-03 JP JP2011535094A patent/JP5378532B2/ja not_active Expired - Fee Related
- 2009-11-03 MX MX2011004954A patent/MX2011004954A/es active IP Right Grant
- 2009-11-03 WO PCT/EP2009/064497 patent/WO2010052199A1/en active Application Filing
- 2009-11-03 CA CA2743196A patent/CA2743196A1/en not_active Abandoned
- 2009-11-03 EP EP09751873A patent/EP2355817A1/en not_active Withdrawn
- 2009-11-04 US US12/612,002 patent/US8288403B2/en not_active Expired - Fee Related
- 2009-11-09 AR ARP090104314A patent/AR074304A1/es unknown
- 2009-11-09 TW TW098137962A patent/TW201021795A/zh unknown
-
2011
- 2011-04-26 IL IL212497A patent/IL212497A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2355817A1 (en) | 2011-08-17 |
| JP2012508211A (ja) | 2012-04-05 |
| JP5378532B2 (ja) | 2013-12-25 |
| MX2011004954A (es) | 2011-05-30 |
| US20100120874A1 (en) | 2010-05-13 |
| TW201021795A (en) | 2010-06-16 |
| US8288403B2 (en) | 2012-10-16 |
| CA2743196A1 (en) | 2010-05-14 |
| CN102209537A (zh) | 2011-10-05 |
| IL212497A0 (en) | 2011-06-30 |
| WO2010052199A1 (en) | 2010-05-14 |
| AU2009312856A1 (en) | 2010-05-14 |
| AR074304A1 (es) | 2011-01-05 |
| KR20110083731A (ko) | 2011-07-20 |
| KR101293421B1 (ko) | 2013-08-05 |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |