EA201170607A1 - Акриламидопроизводные, применимые как ингибиторы перехода митохондриальной проницаемости - Google Patents

Акриламидопроизводные, применимые как ингибиторы перехода митохондриальной проницаемости

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Publication number
EA201170607A1
EA201170607A1 EA201170607A EA201170607A EA201170607A1 EA 201170607 A1 EA201170607 A1 EA 201170607A1 EA 201170607 A EA201170607 A EA 201170607A EA 201170607 A EA201170607 A EA 201170607A EA 201170607 A1 EA201170607 A1 EA 201170607A1
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EA
Eurasian Patent Office
Prior art keywords
acrylamid
inhibitors
compounds
derivatives applicable
derivatives
Prior art date
Application number
EA201170607A
Other languages
English (en)
Other versions
EA020320B1 (ru
Inventor
Даниеле Фанчелли
Марио Варази
Симон Плит
Марко Балларини
Анна Каппа
Джакомо Каренци
Саверио Минуччи
Джиллес Паин
Мануела Вилла
Original Assignee
Конгения Срл
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Publication date
Application filed by Конгения Срл filed Critical Конгения Срл
Publication of EA201170607A1 publication Critical patent/EA201170607A1/ru
Publication of EA020320B1 publication Critical patent/EA020320B1/ru

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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

В данном изобретении описаны акриламидопроизводные, применимые в качестве терапевтических средств, в особенности для предупреждения и/или лечения болезней и состояний, связанных с активностью поры перехода митохондриальной проницаемости (МРТР), таких как болезни, характеризующиеся ишемией/реперфузией, окислительным или дегенеративным повреждением ткани. Эти соединения относятся к структурной формуле (I), где R, R', R", W и а являются такими, как определено в описании. Данное изобретение также касается получения этих соединений, а также фармацевтических композиций, содержащих их.
EA201170607A 2008-10-27 2009-09-23 Акриламидопроизводные, применимые как ингибиторы перехода митохондриальной проницаемости EA020320B1 (ru)

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EP08018742A EP2179984A1 (en) 2008-10-27 2008-10-27 Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
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