CL2011000903A1 - Compuestos derivados de 3-(3-hidroxifenil)-acrilamida sustituidos; procedimientos de preparacion; composicion farmaceutica; utiles en el tratamiento de enfermedades asociadas con la actividad del poro de permeabilidad transitoria mitocondrial (mptp) tales como daño por isquemia/reperfusion, enfermedades neurodegenerativas, entre otras. - Google Patents

Compuestos derivados de 3-(3-hidroxifenil)-acrilamida sustituidos; procedimientos de preparacion; composicion farmaceutica; utiles en el tratamiento de enfermedades asociadas con la actividad del poro de permeabilidad transitoria mitocondrial (mptp) tales como daño por isquemia/reperfusion, enfermedades neurodegenerativas, entre otras.

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Publication number
CL2011000903A1
CL2011000903A1 CL2011000903A CL2011000903A CL2011000903A1 CL 2011000903 A1 CL2011000903 A1 CL 2011000903A1 CL 2011000903 A CL2011000903 A CL 2011000903A CL 2011000903 A CL2011000903 A CL 2011000903A CL 2011000903 A1 CL2011000903 A1 CL 2011000903A1
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CL
Chile
Prior art keywords
activity
compounds
mptp
useful
treatment
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CL2011000903A
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English (en)
Inventor
Daniele Fancelli
Mario Varas
Simon Plyte
Marco Ballarini
Ana Cappa
Giacomo Carenzi
Saverio Minucci
Gilles Pain
Original Assignee
Congenia Srl
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Publication of CL2011000903A1 publication Critical patent/CL2011000903A1/es

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    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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Abstract

DERIVADOS DE ACRILAMIDO ÚTILES COMO AGENTES TERAPÉUTICOS, EN PARTICULAR EN LA PREVENCIÓN Y/O TRATAMIENTO DE ENFERMEDADES Y CONDICIONES ASOCIADAS CON LA ACTIVIDAD DEL PORO DE PERMEABILIDAD TRANSITORIA MITOCONDRIAL (MPTP), TALES COMO ENFERMEDADES CARACTERIZADAS POR ISQUEMIA/REPERFUSIÓN, DAÑO DE TEJIDOS OXIDATIVO O DEGENERATIVO, COMO AQUÍ SE DESCRIBEN ESTOS COMPUESTOS PERTENECEN A LA FÓRMULA ESTRUCTURAL (1) DONDE,  R', R´, R" W SON COMO SE DEFINE EN LA ESPECIFICACiÓN. LA INVENCiÓN TAMBIÉN SE RELACIONA CON LA PREPARACiÓN DE ESTOS COMPUESTOS, COMO TAMBlEN CON LAS COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN.
CL2011000903A 2008-10-27 2011-04-21 Compuestos derivados de 3-(3-hidroxifenil)-acrilamida sustituidos; procedimientos de preparacion; composicion farmaceutica; utiles en el tratamiento de enfermedades asociadas con la actividad del poro de permeabilidad transitoria mitocondrial (mptp) tales como daño por isquemia/reperfusion, enfermedades neurodegenerativas, entre otras. CL2011000903A1 (es)

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EP08018742A EP2179984A1 (en) 2008-10-27 2008-10-27 Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition

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KR101981818B1 (ko) * 2011-06-24 2019-05-23 도오꾜오까고오교 가부시끼가이샤 신규 화합물
US20150182546A1 (en) * 2013-03-15 2015-07-02 Mitochondrial Concepts Llc Therapeutic agent for enhancing mitochondrial function
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US20130245019A1 (en) 2013-09-19
IL212250A (en) 2015-11-30
EP2349982B1 (en) 2015-08-05
KR101631342B1 (ko) 2016-06-16
CN102264693B (zh) 2016-01-27
ES2552051T3 (es) 2015-11-25
SI2349982T1 (sl) 2015-12-31
DK2349982T3 (en) 2015-11-02
IL212250A0 (en) 2011-06-30
EP2349982A1 (en) 2011-08-03
PL2349982T3 (pl) 2016-02-29
AU2009309378B2 (en) 2014-01-16
PT2349982E (pt) 2015-11-23
US20110195977A1 (en) 2011-08-11
AU2009309378A1 (en) 2010-05-06
HK1164274A1 (zh) 2012-09-21
CA2741433A1 (en) 2010-05-06
JP5670338B2 (ja) 2015-02-18
US8669261B2 (en) 2014-03-11
EA201170607A1 (ru) 2011-12-30
CN102264693A (zh) 2011-11-30
JP2012506852A (ja) 2012-03-22
JP2015003921A (ja) 2015-01-08
HUE026249T2 (en) 2016-06-28
EP2179984A1 (en) 2010-04-28
MX2011004363A (es) 2012-01-20
WO2010049768A1 (en) 2010-05-06
NZ592224A (en) 2012-09-28
UA105018C2 (uk) 2014-04-10
EA020320B1 (ru) 2014-10-30
ZA201103047B (en) 2011-12-28
CA2741433C (en) 2016-08-23
BRPI0920506A2 (pt) 2016-09-27
US8470831B2 (en) 2013-06-25

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