BRPI0920506A2 - derivados acrilamida úteis como inibidores da transição de permeabilidade mitocondrial - Google Patents

derivados acrilamida úteis como inibidores da transição de permeabilidade mitocondrial

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Publication number
BRPI0920506A2
BRPI0920506A2 BRPI0920506A BRPI0920506A BRPI0920506A2 BR PI0920506 A2 BRPI0920506 A2 BR PI0920506A2 BR PI0920506 A BRPI0920506 A BR PI0920506A BR PI0920506 A BRPI0920506 A BR PI0920506A BR PI0920506 A2 BRPI0920506 A2 BR PI0920506A2
Authority
BR
Brazil
Prior art keywords
derivatives useful
acrylamide derivatives
permeability transition
mitochondrial permeability
inhibitors
Prior art date
Application number
BRPI0920506A
Other languages
English (en)
Inventor
Anna Cappa
Daniele Fancelli
Giacomo Carenzi
Giles Pain
Manuela Villa
Marco Ballarini
Mario Varasi
Saverio Minucci
Simon Plyte
Original Assignee
Congenia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Congenia Srl filed Critical Congenia Srl
Publication of BRPI0920506A2 publication Critical patent/BRPI0920506A2/pt

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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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BRPI0920506A 2008-10-27 2009-09-23 derivados acrilamida úteis como inibidores da transição de permeabilidade mitocondrial BRPI0920506A2 (pt)

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EP08018742A EP2179984A1 (en) 2008-10-27 2008-10-27 Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
PCT/IB2009/006939 WO2010049768A1 (en) 2008-10-27 2009-09-23 Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition

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IN2012DN03312A (pt) 2009-10-22 2015-10-23 Fibrotech Therapeutics Pty Ltd
JP5722892B2 (ja) * 2010-07-15 2015-05-27 武田薬品工業株式会社 複素環化合物
JP5797476B2 (ja) * 2011-06-24 2015-10-21 株式会社ダイセル 不飽和カルボン酸アミド組成物の製造方法
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WO2014150318A1 (en) * 2013-03-15 2014-09-25 Mitochondrial Concepts Llc Therapeutic agent for enhancing mitochondrial function
WO2015191533A1 (en) * 2014-06-13 2015-12-17 East Carolina University Methods of using carnosinol and analogs thereof
EP2993175A1 (en) 2014-09-05 2016-03-09 IEO - Istituto Europeo di Oncologia Srl Thienopyrroles as histone demethylase inhibitors
CN105601540B (zh) * 2016-04-01 2017-09-29 南阳师范学院 一种4‑氨基甲酸酯‑3‑甲氧基肉桂酸苯酰胺类化合物及其制备方法和用途
EP3526225A1 (en) * 2016-10-14 2019-08-21 Universidade do Porto Hydroxycinnamic derivatives, methods and uses thereof
BR112019013371A2 (pt) * 2017-01-06 2019-12-10 Rivus Pharmaceuticals Inc novos derivados de fenila
US11014873B2 (en) 2017-02-03 2021-05-25 Certa Therapeutics Pty Ltd. Anti-fibrotic compounds
GB202013731D0 (en) 2020-09-01 2020-10-14 Nrg Therapeutics Ltd Novel cmpounds
GB202013728D0 (en) 2020-09-01 2020-10-14 Nrg Therapeutics Ltd Novel compounds
GB202202921D0 (en) 2022-03-02 2022-04-13 Nrg Therapeutics Ltd Novel compounds

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AU2009309378B2 (en) 2014-01-16
AU2009309378A1 (en) 2010-05-06
US8470831B2 (en) 2013-06-25
KR20110089852A (ko) 2011-08-09
WO2010049768A1 (en) 2010-05-06
CL2011000903A1 (es) 2011-11-11
CA2741433C (en) 2016-08-23
DK2349982T3 (en) 2015-11-02
PT2349982E (pt) 2015-11-23
PL2349982T3 (pl) 2016-02-29
ZA201103047B (en) 2011-12-28
EP2349982A1 (en) 2011-08-03
EP2349982B1 (en) 2015-08-05
JP2012506852A (ja) 2012-03-22
HUE026249T2 (en) 2016-06-28
CA2741433A1 (en) 2010-05-06
ES2552051T3 (es) 2015-11-25
IL212250A (en) 2015-11-30
UA105018C2 (uk) 2014-04-10
JP5670338B2 (ja) 2015-02-18
KR101631342B1 (ko) 2016-06-16
US20110195977A1 (en) 2011-08-11
EP2179984A1 (en) 2010-04-28
JP2015003921A (ja) 2015-01-08
CN102264693B (zh) 2016-01-27
US8669261B2 (en) 2014-03-11
NZ592224A (en) 2012-09-28
MX2011004363A (es) 2012-01-20
US20130245019A1 (en) 2013-09-19
HK1164274A1 (zh) 2012-09-21
IL212250A0 (en) 2011-06-30
CN102264693A (zh) 2011-11-30
SI2349982T1 (sl) 2015-12-31
EA020320B1 (ru) 2014-10-30

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