DOP2009000229A - 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas - Google Patents

3-imidazolil-indoles para el tratamiento de enfermedades proliferativas

Info

Publication number
DOP2009000229A
DOP2009000229A DO2009000229A DO2009000229A DOP2009000229A DO P2009000229 A DOP2009000229 A DO P2009000229A DO 2009000229 A DO2009000229 A DO 2009000229A DO 2009000229 A DO2009000229 A DO 2009000229A DO P2009000229 A DOP2009000229 A DO P2009000229A
Authority
DO
Dominican Republic
Prior art keywords
treatment
proliferative diseases
imidazolil
indoles
variants
Prior art date
Application number
DO2009000229A
Other languages
English (en)
Inventor
Pascal Furet
Andreas Boettcher
Nicole Buschmann
Jean-Marc Groell
Jorg Kallen
Joanna Hergovich Lisztwan
Keiichi Masuya
Lorenz Mayr
Andrea Vaupel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38328915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2009000229(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DOP2009000229A publication Critical patent/DOP2009000229A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a compuestos de 3-heterociclil-indolilo capaces de inhibir la interaccion entre p53, o variantes del mismo, y MDM2 y/o MDM4, o variantes de los mismos, respectivamente, teniendo estos compuestos la formula I: en donde: R1, R2, R3, R4, Rn, e Y son como se definen en la memoria descriptiva. Debido a su actividad, los compuestos son utiles en el tratamiento de diferentes trastornos y enfermedades mediadas por la actividad de MDM2 y/o MDM4, o variantes de los mismos, tales coma enfermedades inflamatorias o proliferativas, o en la proteccion de las celulas.
DO2009000229A 2007-03-29 2009-09-28 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas DOP2009000229A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07105269 2007-03-29

Publications (1)

Publication Number Publication Date
DOP2009000229A true DOP2009000229A (es) 2009-10-31

Family

ID=38328915

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2009000229A DOP2009000229A (es) 2007-03-29 2009-09-28 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas

Country Status (27)

Country Link
US (1) US8053457B2 (es)
EP (1) EP2142535A2 (es)
JP (1) JP2010522723A (es)
KR (1) KR20090122403A (es)
CN (1) CN101679382A (es)
AR (1) AR065860A1 (es)
AU (1) AU2008234954B9 (es)
BR (1) BRPI0810082A2 (es)
CA (1) CA2682483A1 (es)
CL (1) CL2008000899A1 (es)
CR (1) CR11019A (es)
DO (1) DOP2009000229A (es)
EA (1) EA200901212A1 (es)
EC (1) ECSP099660A (es)
GT (1) GT200900256A (es)
IL (1) IL200862A0 (es)
MA (1) MA31260B1 (es)
MX (1) MX2009010413A (es)
NI (1) NI200900177A (es)
PA (1) PA8774001A1 (es)
PE (1) PE20081897A1 (es)
SM (1) SMP200900085B (es)
TN (1) TN2009000388A1 (es)
TW (1) TW200843746A (es)
UY (1) UY30987A1 (es)
WO (1) WO2008119741A2 (es)
ZA (1) ZA200906210B (es)

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Also Published As

Publication number Publication date
EP2142535A2 (en) 2010-01-13
CR11019A (es) 2009-10-20
GT200900256A (es) 2010-03-15
TN2009000388A1 (en) 2010-12-31
MA31260B1 (fr) 2010-03-01
NI200900177A (es) 2010-09-09
CL2008000899A1 (es) 2009-02-20
CA2682483A1 (en) 2008-10-09
ECSP099660A (es) 2009-10-30
ZA200906210B (en) 2010-05-26
EA200901212A1 (ru) 2010-04-30
CN101679382A (zh) 2010-03-24
TW200843746A (en) 2008-11-16
AR065860A1 (es) 2009-07-08
PE20081897A1 (es) 2009-02-09
SMP200900085B (it) 2010-11-12
WO2008119741A3 (en) 2008-12-04
BRPI0810082A2 (pt) 2014-10-21
WO2008119741A2 (en) 2008-10-09
UY30987A1 (es) 2008-10-31
PA8774001A1 (es) 2008-11-19
KR20090122403A (ko) 2009-11-27
MX2009010413A (es) 2009-10-20
AU2008234954B2 (en) 2011-10-27
US8053457B2 (en) 2011-11-08
JP2010522723A (ja) 2010-07-08
AU2008234954B9 (en) 2012-02-02
IL200862A0 (en) 2010-05-17
SMAP200900085A (it) 2010-01-19
AU2008234954A1 (en) 2008-10-09
US20100125064A1 (en) 2010-05-20

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