CR20150068A - Ciclopentilpirazoles como bloqueadores del canal de calcio tipo n - Google Patents

Ciclopentilpirazoles como bloqueadores del canal de calcio tipo n

Info

Publication number
CR20150068A
CR20150068A CR20150068A CR20150068A CR20150068A CR 20150068 A CR20150068 A CR 20150068A CR 20150068 A CR20150068 A CR 20150068A CR 20150068 A CR20150068 A CR 20150068A CR 20150068 A CR20150068 A CR 20150068A
Authority
CR
Costa Rica
Prior art keywords
cyclopentilpirazoles
blockers
channel type
calcium channel
compounds
Prior art date
Application number
CR20150068A
Other languages
English (en)
Inventor
Michael P Winters
Zhihua Sui
Christopher Flores
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49036654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20150068(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR20150068A publication Critical patent/CR20150068A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/113Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen compuestos, composiciones y métodos para el tratamiento de varias enfermedades, síndromes, afecciones y trastornos, que incluyen el dolor. Tales compuestos están representados por la Fórmula (I) en donde R1, R2, R3, Q, y G se definen en la presente descripción.
CR20150068A 2012-08-16 2015-02-10 Ciclopentilpirazoles como bloqueadores del canal de calcio tipo n CR20150068A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683775P 2012-08-16 2012-08-16
PCT/US2013/055267 WO2014028801A1 (en) 2012-08-16 2013-08-16 Cyclopentylpyrazoles as n-type calcium channel blockers

Publications (1)

Publication Number Publication Date
CR20150068A true CR20150068A (es) 2015-04-30

Family

ID=49036654

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150068A CR20150068A (es) 2012-08-16 2015-02-10 Ciclopentilpirazoles como bloqueadores del canal de calcio tipo n

Country Status (21)

Country Link
US (1) US8853418B2 (es)
EP (1) EP2885279A1 (es)
JP (1) JP6262231B2 (es)
KR (1) KR20150042270A (es)
CN (1) CN105189464B (es)
AU (1) AU2013302469B2 (es)
BR (1) BR112015003328A2 (es)
CA (1) CA2882042A1 (es)
CL (1) CL2015000357A1 (es)
CR (1) CR20150068A (es)
EA (1) EA201590382A1 (es)
EC (1) ECSP15009830A (es)
HK (1) HK1217690A1 (es)
IL (1) IL237189A0 (es)
IN (1) IN2015DN01237A (es)
MX (1) MX2015002037A (es)
PE (1) PE20151137A1 (es)
PH (1) PH12015500314A1 (es)
SG (1) SG11201501140RA (es)
WO (1) WO2014028801A1 (es)
ZA (1) ZA201501746B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201501130PA (en) 2012-08-16 2015-04-29 Janssen Pharmaceutica Nv Substituted pyrazoles as n-type calcium channel blockers
EP2957559A1 (en) * 2014-06-18 2015-12-23 L'Universite de Strasbourg Iminosydnone derivatives for conjugation and release of compounds of interest

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1287174B1 (it) * 1996-11-15 1998-08-04 Angelini Ricerche Spa Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono
JP2001220390A (ja) * 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
BRPI0508594A (pt) * 2004-03-08 2007-08-21 Wyeth Corp moduladores de canal de ìon
CA2558214A1 (en) * 2004-03-08 2005-09-22 Wyeth Ion channel modulators
CN101304975A (zh) * 2005-11-09 2008-11-12 艾博特公司 P2x7受体拮抗剂及其用途

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Also Published As

Publication number Publication date
SG11201501140RA (en) 2015-04-29
PE20151137A1 (es) 2015-08-07
MX2015002037A (es) 2016-01-22
HK1217690A1 (zh) 2017-01-20
JP2015524851A (ja) 2015-08-27
JP6262231B2 (ja) 2018-01-17
CN105189464A (zh) 2015-12-23
US8853418B2 (en) 2014-10-07
EP2885279A1 (en) 2015-06-24
IL237189A0 (en) 2015-04-30
CA2882042A1 (en) 2014-02-20
US20140051660A1 (en) 2014-02-20
AU2013302469B2 (en) 2017-08-24
ZA201501746B (en) 2017-08-30
WO2014028801A1 (en) 2014-02-20
BR112015003328A2 (pt) 2017-07-04
EA201590382A1 (ru) 2015-08-31
AU2013302469A1 (en) 2015-02-26
CL2015000357A1 (es) 2015-06-12
IN2015DN01237A (es) 2015-06-26
PH12015500314A1 (en) 2015-03-30
CN105189464B (zh) 2017-12-12
ECSP15009830A (es) 2015-12-31
KR20150042270A (ko) 2015-04-20

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