BR112015003328A2 - ciclopentilpirazóis como bloqueadores de canal de cálcio de tipo-n - Google Patents

ciclopentilpirazóis como bloqueadores de canal de cálcio de tipo-n

Info

Publication number
BR112015003328A2
BR112015003328A2 BR112015003328A BR112015003328A BR112015003328A2 BR 112015003328 A2 BR112015003328 A2 BR 112015003328A2 BR 112015003328 A BR112015003328 A BR 112015003328A BR 112015003328 A BR112015003328 A BR 112015003328A BR 112015003328 A2 BR112015003328 A2 BR 112015003328A2
Authority
BR
Brazil
Prior art keywords
cyclopentylpyrazoles
compounds
calcium channel
channel blockers
type calcium
Prior art date
Application number
BR112015003328A
Other languages
English (en)
Inventor
Flores Christopher
P Winters Michael
Sui Zhihua
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49036654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015003328(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112015003328A2 publication Critical patent/BR112015003328A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

abstract disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. such compounds are represented by formula (i) as follows: formula (i) wherein r1, r2 , r3 , q , and g are defined herein. __________________________________________ tradução do resumo resumo patente de invenção: "ciclopentilpirazóis como bloquea-dores de canal de cálcio de tipo-n". a presente invenção refere-se aos compostos, às compo-sições e aos métodos para o tratamento de várias doenças, síndro-mes, condições e distúrbios, incluindo dor. tais compostos são repre-sentados pela fórmula (i) a seguir, fórmula (i) em que r1, r2, r3, q, e g são aqui definidos.
BR112015003328A 2012-08-16 2013-08-16 ciclopentilpirazóis como bloqueadores de canal de cálcio de tipo-n BR112015003328A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683775P 2012-08-16 2012-08-16
PCT/US2013/055267 WO2014028801A1 (en) 2012-08-16 2013-08-16 Cyclopentylpyrazoles as n-type calcium channel blockers

Publications (1)

Publication Number Publication Date
BR112015003328A2 true BR112015003328A2 (pt) 2017-07-04

Family

ID=49036654

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015003328A BR112015003328A2 (pt) 2012-08-16 2013-08-16 ciclopentilpirazóis como bloqueadores de canal de cálcio de tipo-n

Country Status (21)

Country Link
US (1) US8853418B2 (pt)
EP (1) EP2885279A1 (pt)
JP (1) JP6262231B2 (pt)
KR (1) KR20150042270A (pt)
CN (1) CN105189464B (pt)
AU (1) AU2013302469B2 (pt)
BR (1) BR112015003328A2 (pt)
CA (1) CA2882042A1 (pt)
CL (1) CL2015000357A1 (pt)
CR (1) CR20150068A (pt)
EA (1) EA201590382A1 (pt)
EC (1) ECSP15009830A (pt)
HK (1) HK1217690A1 (pt)
IL (1) IL237189A0 (pt)
IN (1) IN2015DN01237A (pt)
MX (1) MX2015002037A (pt)
PE (1) PE20151137A1 (pt)
PH (1) PH12015500314A1 (pt)
SG (1) SG11201501140RA (pt)
WO (1) WO2014028801A1 (pt)
ZA (1) ZA201501746B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9434693B2 (en) 2012-08-16 2016-09-06 Janssen Pharmaceutica Nv Substituted pyrazoles as N-type calcium channel blockers
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
EP2957559A1 (en) * 2014-06-18 2015-12-23 L'Universite de Strasbourg Iminosydnone derivatives for conjugation and release of compounds of interest

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1287174B1 (it) * 1996-11-15 1998-08-04 Angelini Ricerche Spa Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono
JP2001220390A (ja) * 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
CN1938023A (zh) * 2004-03-08 2007-03-28 惠氏公司 离子通道调节剂
WO2005087747A1 (en) * 2004-03-08 2005-09-22 Wyeth Ion channel modulators
CN101304975A (zh) * 2005-11-09 2008-11-12 艾博特公司 P2x7受体拮抗剂及其用途

Also Published As

Publication number Publication date
CA2882042A1 (en) 2014-02-20
IL237189A0 (en) 2015-04-30
IN2015DN01237A (pt) 2015-06-26
JP2015524851A (ja) 2015-08-27
PE20151137A1 (es) 2015-08-07
JP6262231B2 (ja) 2018-01-17
PH12015500314A1 (en) 2015-03-30
CL2015000357A1 (es) 2015-06-12
SG11201501140RA (en) 2015-04-29
HK1217690A1 (zh) 2017-01-20
US20140051660A1 (en) 2014-02-20
EA201590382A1 (ru) 2015-08-31
US8853418B2 (en) 2014-10-07
AU2013302469A1 (en) 2015-02-26
ZA201501746B (en) 2017-08-30
EP2885279A1 (en) 2015-06-24
CR20150068A (es) 2015-04-30
CN105189464B (zh) 2017-12-12
WO2014028801A1 (en) 2014-02-20
CN105189464A (zh) 2015-12-23
KR20150042270A (ko) 2015-04-20
ECSP15009830A (es) 2015-12-31
MX2015002037A (es) 2016-01-22
AU2013302469B2 (en) 2017-08-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]