CR11759A - Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas - Google Patents

Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas

Info

Publication number
CR11759A
CR11759A CR11759A CR11759A CR11759A CR 11759 A CR11759 A CR 11759A CR 11759 A CR11759 A CR 11759A CR 11759 A CR11759 A CR 11759A CR 11759 A CR11759 A CR 11759A
Authority
CR
Costa Rica
Prior art keywords
espiro
piperidines
treatment
neurodegenerative diseases
new class
Prior art date
Application number
CR11759A
Other languages
English (en)
Inventor
Michael Aaron Brodney
Chiristopher John Helal
Brian Thomas O'neill
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR11759A publication Critical patent/CR11759A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se desvelan compuestos y sales farmaceuticamente aceptables de los compuestos, teniendo los compuestos la estructura de la formula I, como se define en la memoria descriptiva.
CR11759A 2008-05-05 2010-10-26 Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas CR11759A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5042308P 2008-05-05 2008-05-05

Publications (1)

Publication Number Publication Date
CR11759A true CR11759A (es) 2010-11-22

Family

ID=40902870

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11759A CR11759A (es) 2008-05-05 2010-10-26 Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas

Country Status (22)

Country Link
US (1) US20110046160A1 (es)
EP (1) EP2300484B1 (es)
JP (1) JP2011519913A (es)
KR (1) KR20110000749A (es)
CN (1) CN102083841A (es)
AP (1) AP2010005456A0 (es)
AT (1) ATE537178T1 (es)
AU (1) AU2009245322B2 (es)
BR (1) BRPI0912433A2 (es)
CA (1) CA2721786A1 (es)
CO (1) CO6321280A2 (es)
CR (1) CR11759A (es)
DO (1) DOP2010000317A (es)
EA (1) EA201001566A1 (es)
EC (1) ECSP10010597A (es)
ES (1) ES2375913T3 (es)
IL (1) IL208793A0 (es)
MA (1) MA32290B1 (es)
MX (1) MX2010012066A (es)
NZ (1) NZ588589A (es)
SV (1) SV2010003725A (es)
WO (1) WO2009136350A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
JP2013523806A (ja) * 2010-04-09 2013-06-17 ファイザー・インク スルタム化合物
EP2694521B1 (en) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2694489B1 (en) 2011-04-07 2017-09-06 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
JP2014524472A (ja) 2011-08-22 2014-09-22 メルク・シャープ・アンド・ドーム・コーポレーション Ｂａｃｅ阻害剤としての２−スピロ置換イミノチアジンならびにそのモノオキシドおよびジオキシド、組成物、ならびにそれらの使用
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068463A1 (en) * 2004-01-08 2005-07-28 F. Hoffmann-La Roche Ag Diaza-spiropiperidine derivatives
JP2006044497A (ja) * 2004-08-05 2006-02-16 Toyota Motor Corp 車輪情報処理装置
AU2005295814A1 (en) * 2004-10-13 2006-04-27 Merck & Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of Alzhermer's disease
ATE550338T1 (de) * 2005-07-18 2012-04-15 Merck Sharp & Dohme Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
EP2063889A4 (en) * 2006-09-07 2009-09-16 Merck & Co Inc SPIROPIPERIDINE BETA SEKRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER DISEASE
WO2008085509A1 (en) * 2007-01-04 2008-07-17 Merck & Co., Inc. Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease

Also Published As

Publication number Publication date
IL208793A0 (en) 2010-12-30
BRPI0912433A2 (pt) 2015-12-22
EA201001566A1 (ru) 2011-04-29
EP2300484B1 (en) 2011-12-14
ECSP10010597A (es) 2010-12-30
WO2009136350A1 (en) 2009-11-12
AU2009245322A1 (en) 2009-11-12
ES2375913T3 (es) 2012-03-07
NZ588589A (en) 2012-07-27
MA32290B1 (fr) 2011-05-02
JP2011519913A (ja) 2011-07-14
EP2300484A1 (en) 2011-03-30
CA2721786A1 (en) 2009-11-12
US20110046160A1 (en) 2011-02-24
KR20110000749A (ko) 2011-01-05
SV2010003725A (es) 2011-07-05
CN102083841A (zh) 2011-06-01
CO6321280A2 (es) 2011-09-20
ATE537178T1 (de) 2011-12-15
DOP2010000317A (es) 2010-11-15
AP2010005456A0 (en) 2010-12-31
AU2009245322B2 (en) 2011-07-14
MX2010012066A (es) 2010-12-06

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Legal Events

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