MA32290B1 - Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénératives - Google Patents
Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénérativesInfo
- Publication number
- MA32290B1 MA32290B1 MA33328A MA33328A MA32290B1 MA 32290 B1 MA32290 B1 MA 32290B1 MA 33328 A MA33328 A MA 33328A MA 33328 A MA33328 A MA 33328A MA 32290 B1 MA32290 B1 MA 32290B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- biperidenate
- spiro
- new class
- neurological diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention concerne des composés et des sels pharmaceutiquement acceptables de ces composés, les composés ayant la structure de la formule (i) telle que définie dans la description. La présente invention concerne également des compositions pharmaceutiques correspondantes, des procédés de traitement, des procédés de synthèse, et des intermédiaires.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5042308P | 2008-05-05 | 2008-05-05 | |
PCT/IB2009/051815 WO2009136350A1 (fr) | 2008-05-05 | 2009-05-04 | Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénératives |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32290B1 true MA32290B1 (fr) | 2011-05-02 |
Family
ID=40902870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33328A MA32290B1 (fr) | 2008-05-05 | 2010-11-05 | Nouvelle classe de spiro pipéridines pour le traitement de maladies neurodégénératives |
Country Status (22)
Country | Link |
---|---|
US (1) | US20110046160A1 (fr) |
EP (1) | EP2300484B1 (fr) |
JP (1) | JP2011519913A (fr) |
KR (1) | KR20110000749A (fr) |
CN (1) | CN102083841A (fr) |
AP (1) | AP2010005456A0 (fr) |
AT (1) | ATE537178T1 (fr) |
AU (1) | AU2009245322B2 (fr) |
BR (1) | BRPI0912433A2 (fr) |
CA (1) | CA2721786A1 (fr) |
CO (1) | CO6321280A2 (fr) |
CR (1) | CR11759A (fr) |
DO (1) | DOP2010000317A (fr) |
EA (1) | EA201001566A1 (fr) |
EC (1) | ECSP10010597A (fr) |
ES (1) | ES2375913T3 (fr) |
IL (1) | IL208793A0 (fr) |
MA (1) | MA32290B1 (fr) |
MX (1) | MX2010012066A (fr) |
NZ (1) | NZ588589A (fr) |
SV (1) | SV2010003725A (fr) |
WO (1) | WO2009136350A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
EP2556076A2 (fr) * | 2010-04-09 | 2013-02-13 | Pfizer Inc. | Nouveaux composés sultame |
US9221839B2 (en) | 2011-04-07 | 2015-12-29 | Merck Sharp & Dohme Corp. | C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
WO2012138590A1 (fr) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Composés de dioxyde de thiadiazine fusionnée à la pyrrolidine en tant qu'inhibiteurs de bace, compositions et leur utilisation |
AU2012298983A1 (en) | 2011-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use |
US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
EP3233077A4 (fr) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Ligands des récepteurs dopaminergiques d2 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1720873B1 (fr) * | 2004-01-08 | 2011-02-23 | F. Hoffmann-La Roche AG | Derives de diaza-spiropiperidine |
JP2006044497A (ja) * | 2004-08-05 | 2006-02-16 | Toyota Motor Corp | 車輪情報処理装置 |
WO2006044497A2 (fr) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Composes de spiropiperidine utilises comme inhibiteurs de beta-secretase en vue du traitement de la maladie d'alzheimer |
WO2007011833A2 (fr) * | 2005-07-18 | 2007-01-25 | Merck & Co., Inc. | Inhibiteurs de spiropiperidine beta-secretase pour le traitement de la maladie d'alzheimer |
CA2662776A1 (fr) * | 2006-09-07 | 2008-03-13 | Merck And Co., Inc. | Inhibiteurs de la spiropiperidine beta-secretase pour le traitement de la maladie d'alzheimer |
EP2117309B1 (fr) * | 2007-01-04 | 2013-11-06 | Merck Sharp & Dohme Corp. | Inhibiteurs de la bêta-sécrétase de spiropipéridine bi-cyclique destinés au traitement de la maladie d'alzheimer |
-
2009
- 2009-05-04 AT AT09742523T patent/ATE537178T1/de active
- 2009-05-04 CN CN2009801261947A patent/CN102083841A/zh active Pending
- 2009-05-04 JP JP2011508035A patent/JP2011519913A/ja not_active Withdrawn
- 2009-05-04 BR BRPI0912433A patent/BRPI0912433A2/pt not_active Application Discontinuation
- 2009-05-04 NZ NZ588589A patent/NZ588589A/en not_active IP Right Cessation
- 2009-05-04 KR KR1020107024794A patent/KR20110000749A/ko not_active Application Discontinuation
- 2009-05-04 MX MX2010012066A patent/MX2010012066A/es not_active Application Discontinuation
- 2009-05-04 AP AP2010005456A patent/AP2010005456A0/xx unknown
- 2009-05-04 US US12/990,739 patent/US20110046160A1/en not_active Abandoned
- 2009-05-04 EA EA201001566A patent/EA201001566A1/ru unknown
- 2009-05-04 EP EP09742523A patent/EP2300484B1/fr active Active
- 2009-05-04 CA CA2721786A patent/CA2721786A1/fr not_active Abandoned
- 2009-05-04 AU AU2009245322A patent/AU2009245322B2/en not_active Ceased
- 2009-05-04 WO PCT/IB2009/051815 patent/WO2009136350A1/fr active Application Filing
- 2009-05-04 ES ES09742523T patent/ES2375913T3/es active Active
-
2010
- 2010-10-18 IL IL208793A patent/IL208793A0/en unknown
- 2010-10-21 DO DO2010000317A patent/DOP2010000317A/es unknown
- 2010-10-26 CR CR11759A patent/CR11759A/es not_active Application Discontinuation
- 2010-11-05 SV SV2010003725A patent/SV2010003725A/es not_active Application Discontinuation
- 2010-11-05 MA MA33328A patent/MA32290B1/fr unknown
- 2010-11-09 EC EC2010010597A patent/ECSP10010597A/es unknown
- 2010-11-11 CO CO10141834A patent/CO6321280A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DOP2010000317A (es) | 2010-11-15 |
AU2009245322B2 (en) | 2011-07-14 |
CA2721786A1 (fr) | 2009-11-12 |
IL208793A0 (en) | 2010-12-30 |
EP2300484B1 (fr) | 2011-12-14 |
US20110046160A1 (en) | 2011-02-24 |
AP2010005456A0 (en) | 2010-12-31 |
CO6321280A2 (es) | 2011-09-20 |
MX2010012066A (es) | 2010-12-06 |
WO2009136350A1 (fr) | 2009-11-12 |
ATE537178T1 (de) | 2011-12-15 |
CN102083841A (zh) | 2011-06-01 |
JP2011519913A (ja) | 2011-07-14 |
BRPI0912433A2 (pt) | 2015-12-22 |
EA201001566A1 (ru) | 2011-04-29 |
CR11759A (es) | 2010-11-22 |
EP2300484A1 (fr) | 2011-03-30 |
ECSP10010597A (es) | 2010-12-30 |
KR20110000749A (ko) | 2011-01-05 |
SV2010003725A (es) | 2011-07-05 |
AU2009245322A1 (en) | 2009-11-12 |
ES2375913T3 (es) | 2012-03-07 |
NZ588589A (en) | 2012-07-27 |
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