CR11019A - 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas - Google Patents

3-imidazolil-indoles para el tratamiento de enfermedades proliferativas

Info

Publication number
CR11019A
CR11019A CR11019A CR11019A CR11019A CR 11019 A CR11019 A CR 11019A CR 11019 A CR11019 A CR 11019A CR 11019 A CR11019 A CR 11019A CR 11019 A CR11019 A CR 11019A
Authority
CR
Costa Rica
Prior art keywords
imidazolil
indoles
treatment
proliferative diseases
proliferative
Prior art date
Application number
CR11019A
Other languages
English (en)
Inventor
Boettcher Andreas
Buschmann Nicole
Furet Pascal
Groell Jean-Marc
Kallen Jorg
Hergovich Lisztwan Joanna
Masuya Keiichi
Mayr Lorenz
Vaupel Andrea
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38328915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR11019(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR11019A publication Critical patent/CR11019A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CR11019A 2007-03-29 2009-09-09 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas CR11019A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07105269 2007-03-29

Publications (1)

Publication Number Publication Date
CR11019A true CR11019A (es) 2009-10-20

Family

ID=38328915

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11019A CR11019A (es) 2007-03-29 2009-09-09 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas

Country Status (27)

Country Link
US (1) US8053457B2 (es)
EP (1) EP2142535A2 (es)
JP (1) JP2010522723A (es)
KR (1) KR20090122403A (es)
CN (1) CN101679382A (es)
AR (1) AR065860A1 (es)
AU (1) AU2008234954B9 (es)
BR (1) BRPI0810082A2 (es)
CA (1) CA2682483A1 (es)
CL (1) CL2008000899A1 (es)
CR (1) CR11019A (es)
DO (1) DOP2009000229A (es)
EA (1) EA200901212A1 (es)
EC (1) ECSP099660A (es)
GT (1) GT200900256A (es)
IL (1) IL200862A0 (es)
MA (1) MA31260B1 (es)
MX (1) MX2009010413A (es)
NI (1) NI200900177A (es)
PA (1) PA8774001A1 (es)
PE (1) PE20081897A1 (es)
SM (1) SMP200900085B (es)
TN (1) TN2009000388A1 (es)
TW (1) TW200843746A (es)
UY (1) UY30987A1 (es)
WO (1) WO2008119741A2 (es)
ZA (1) ZA200906210B (es)

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CN103201263A (zh) 2010-09-08 2013-07-10 匹兹堡高等教育联邦体系大学 p53-Mdm2拮抗剂
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
EP2638046A4 (en) 2010-11-12 2014-06-25 Univ Michigan SPIRO-OXINDOLES ANTAGONISTS OF MDM2
US20120202794A1 (en) * 2011-01-24 2012-08-09 Pharmasset, Inc. Compounds
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WO2012176123A1 (en) * 2011-06-22 2012-12-27 Novartis Ag 3 - imidazolyl- indoles for the treatment of proliferative diseases
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
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WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
WO2014028487A1 (en) 2012-08-13 2014-02-20 Massachusetts Institute Of Technology Amine-containing lipidoids and uses thereof
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
ES2707305T3 (es) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de HDM2
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
SG11201606239UA (en) 2014-01-28 2016-08-30 Buck Inst For Res On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
EP3708170A1 (en) 2014-05-05 2020-09-16 BioVentures, LLC Compositions and methods for inhibiting antiapoptotic bcl-2 proteins as anti-aging agents
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
EP3164401B1 (en) 2014-07-03 2018-12-26 Boehringer Ingelheim International GmbH New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
CA2955972A1 (en) 2014-07-22 2016-01-28 Bioventures, Llc. Compositions and methods for selectively depleting senescent cells
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CA2976752C (en) 2015-02-20 2019-12-17 Daiichi Sankyo Company, Limited Method for treating cancer by combined use
WO2016167236A1 (ja) 2015-04-13 2016-10-20 第一三共株式会社 Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法
WO2016207089A1 (de) * 2015-06-22 2016-12-29 Bayer Pharma Aktiengesellschaft Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
TWI737635B (zh) 2015-10-09 2021-09-01 德商百靈佳殷格翰國際股份有限公司 作為mdm2－p53抑制劑之新穎螺﹝3h－吲哚－3，2´－吡咯啶﹞－2（1h）－酮化合物及其衍生物
WO2017176958A1 (en) 2016-04-06 2017-10-12 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
US11192898B2 (en) 2016-04-06 2021-12-07 The Regents Of The University Of Michigan MDM2 protein degraders
CN109152933B (zh) 2016-04-21 2022-12-02 生物风险投资有限责任公司 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途
CN105906610B (zh) * 2016-05-24 2018-10-23 绍兴文理学院 一种3-（4-苯基-1h-咪唑-5-基）-1h-吲哚衍生物及其制备方法和应用
EP3272745B1 (en) * 2016-07-21 2019-06-26 Instytut Farmakologii Polskiej Akademii Nauk Imidazolyl-substituted indole derivatives binding 5-ht7 serotonin receptor and pharmaceutical compositions thereof
TW201818934A (zh) 2016-10-17 2018-06-01 日商第一三共股份有限公司 Ｍｄｍ２抑制劑與ｄｎａ甲基轉移酶抑制劑之倂用治療法
TW201831477A (zh) * 2016-11-28 2018-09-01 瑞士商赫孚孟拉羅股份公司 噁二唑酮瞬時受體電位通道抑制劑
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CN110461838B (zh) 2017-03-07 2022-05-06 豪夫迈·罗氏有限公司 噁二唑瞬时受体电位通道抑制剂
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JP7281822B2 (ja) * 2017-05-26 2023-05-26 ラトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー 細菌の排出ポンプ阻害剤
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
WO2019221755A1 (en) 2018-05-18 2019-11-21 Bioventures, Llc Piperlongumine analogues and uses thereof
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣３多肽之持續遞送
EP3931188B1 (en) * 2019-02-26 2023-08-30 Boehringer Ingelheim International GmbH New isoindolinone substituted indoles and derivatives as ras inhibitors
TW202241873A (zh) * 2020-12-22 2022-11-01 瑞士商諾華公司 用於治療與ｃｇａｓ相關的病症之化合物及組成物
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Also Published As

Publication number Publication date
CA2682483A1 (en) 2008-10-09
WO2008119741A2 (en) 2008-10-09
AR065860A1 (es) 2009-07-08
US8053457B2 (en) 2011-11-08
NI200900177A (es) 2010-09-09
SMP200900085B (it) 2010-11-12
AU2008234954B2 (en) 2011-10-27
EP2142535A2 (en) 2010-01-13
PE20081897A1 (es) 2009-02-09
JP2010522723A (ja) 2010-07-08
WO2008119741A3 (en) 2008-12-04
EA200901212A1 (ru) 2010-04-30
ECSP099660A (es) 2009-10-30
IL200862A0 (en) 2010-05-17
CL2008000899A1 (es) 2009-02-20
PA8774001A1 (es) 2008-11-19
KR20090122403A (ko) 2009-11-27
MX2009010413A (es) 2009-10-20
BRPI0810082A2 (pt) 2014-10-21
AU2008234954B9 (en) 2012-02-02
DOP2009000229A (es) 2009-10-31
CN101679382A (zh) 2010-03-24
TN2009000388A1 (en) 2010-12-31
SMAP200900085A (it) 2010-01-19
MA31260B1 (fr) 2010-03-01
ZA200906210B (en) 2010-05-26
GT200900256A (es) 2010-03-15
TW200843746A (en) 2008-11-16
AU2008234954A1 (en) 2008-10-09
UY30987A1 (es) 2008-10-31
US20100125064A1 (en) 2010-05-20

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