ZA200906210B - 3-Imidazolyl-Indoles for the treatment of proliferative diseases - Google Patents

3-Imidazolyl-Indoles for the treatment of proliferative diseases

Info

Publication number
ZA200906210B
ZA200906210B ZA200906210A ZA200906210A ZA200906210B ZA 200906210 B ZA200906210 B ZA 200906210B ZA 200906210 A ZA200906210 A ZA 200906210A ZA 200906210 A ZA200906210 A ZA 200906210A ZA 200906210 B ZA200906210 B ZA 200906210B
Authority
ZA
South Africa
Prior art keywords
indoles
imidazolyl
treatment
proliferative diseases
proliferative
Prior art date
Application number
ZA200906210A
Other languages
English (en)
Inventor
Andreas Boettcher
Nicole Buschmann
Pascal Furet
Jean-March Groell
Joerg Kallen
Lisztwan Joanna Hergovich
Keiichi Masuya
Lorenz Mayr
Andrea Vaupel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38328915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200906210(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200906210B publication Critical patent/ZA200906210B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200906210A 2007-03-29 2009-09-08 3-Imidazolyl-Indoles for the treatment of proliferative diseases ZA200906210B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07105269 2007-03-29

Publications (1)

Publication Number Publication Date
ZA200906210B true ZA200906210B (en) 2010-05-26

Family

ID=38328915

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200906210A ZA200906210B (en) 2007-03-29 2009-09-08 3-Imidazolyl-Indoles for the treatment of proliferative diseases

Country Status (27)

Country Link
US (1) US8053457B2 (es)
EP (1) EP2142535A2 (es)
JP (1) JP2010522723A (es)
KR (1) KR20090122403A (es)
CN (1) CN101679382A (es)
AR (1) AR065860A1 (es)
AU (1) AU2008234954B9 (es)
BR (1) BRPI0810082A2 (es)
CA (1) CA2682483A1 (es)
CL (1) CL2008000899A1 (es)
CR (1) CR11019A (es)
DO (1) DOP2009000229A (es)
EA (1) EA200901212A1 (es)
EC (1) ECSP099660A (es)
GT (1) GT200900256A (es)
IL (1) IL200862A0 (es)
MA (1) MA31260B1 (es)
MX (1) MX2009010413A (es)
NI (1) NI200900177A (es)
PA (1) PA8774001A1 (es)
PE (1) PE20081897A1 (es)
SM (1) SMP200900085B (es)
TN (1) TN2009000388A1 (es)
TW (1) TW200843746A (es)
UY (1) UY30987A1 (es)
WO (1) WO2008119741A2 (es)
ZA (1) ZA200906210B (es)

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WO2011106650A2 (en) * 2010-02-27 2011-09-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Novel p53-mdm2/p53-mdm4 antagonists to treat proliferative disease
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FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
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US20120202794A1 (en) * 2011-01-24 2012-08-09 Pharmasset, Inc. Compounds
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CN102702066A (zh) * 2011-03-28 2012-10-03 苏州百灵威超精细材料有限公司 一种用于合成抗癌和减肥药物中间体6-氯-5-氟吲哚的制备新方法
SG194873A1 (en) 2011-05-11 2013-12-30 Sanofi Sa Spiro-oxindole mdm2 antagonists
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
WO2012176123A1 (en) * 2011-06-22 2012-12-27 Novartis Ag 3 - imidazolyl- indoles for the treatment of proliferative diseases
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US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
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RU2690663C2 (ru) 2012-12-20 2019-06-05 Мерк Шарп И Доум Корп. Замещенные имидазопиридины в качестве ингибиторов hdm2
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
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WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
WO2015171591A1 (en) 2014-05-05 2015-11-12 Board Of Trustees Of The University Of Arkansas COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
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WO2016001376A1 (en) 2014-07-03 2016-01-07 Boehringer Ingelheim International Gmbh New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
WO2016014625A1 (en) 2014-07-22 2016-01-28 Board Of Trustees Of The University Of Arkansas Compositions and methods for selectively depleting senescent cells
JP2018502846A (ja) 2014-12-26 2018-02-01 ダウ グローバル テクノロジーズ エルエルシー 有機化合物、及び有機化合物を含む有機層を備える電子デバイス
TWI711452B (zh) 2015-02-20 2020-12-01 日商第一三共股份有限公司 癌症的倂用治療法
EP3284466A4 (en) 2015-04-13 2018-12-05 Daiichi Sankyo Company, Limited Treatment method combining mdm2 inhibitor and btk inhibitor
CN108025084A (zh) * 2015-06-22 2018-05-11 拜耳医药股份有限公司 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc）
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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SG11201808728QA (en) 2016-04-06 2018-11-29 Univ Michigan Regents Mdm2 protein degraders
US10759808B2 (en) 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
JP6936498B2 (ja) 2016-04-21 2021-09-15 バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ， ＬＬＣ 抗アポトーシス性Ｂｃｌ−２ファミリータンパク質の分解を誘導する化合物及びその使用
CN105906610B (zh) * 2016-05-24 2018-10-23 绍兴文理学院 一种3-（4-苯基-1h-咪唑-5-基）-1h-吲哚衍生物及其制备方法和应用
DK3272745T3 (da) * 2016-07-21 2019-09-02 Inst Farmakologii Polskiej Akademii Nauk Imidazolylsubstituerede indolderivater, der binder 5-ht7-serotoninreceptor, og farmaceutiske sammensætninger deraf
JPWO2018074387A1 (ja) 2016-10-17 2019-08-08 第一三共株式会社 Ｍｄｍ２阻害剤とｄｎａメチルトランスフェラーゼ阻害剤との併用治療法
EP3544979B1 (en) * 2016-11-28 2021-08-04 F. Hoffmann-La Roche AG Oxadiazolones as transient receptor potential channel inhibitors
MX2019007641A (es) 2016-12-21 2019-09-09 Bayer Pharma AG Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente.
EP3592739A1 (en) 2017-03-07 2020-01-15 H. Hoffnabb-La Roche Ag Oxadiazole transient receptor potential channel inhibitors
MX2019011945A (es) 2017-04-05 2019-11-28 Boehringer Ingelheim Int Terapia de combinacion contra cancer.
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
EP3630109A4 (en) * 2017-05-26 2021-03-17 Rutgers, the State University of New Jersey BACTERIAL DRAIN PUMP INHIBITORS
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣３多肽之持續遞送
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Also Published As

Publication number Publication date
US20100125064A1 (en) 2010-05-20
ECSP099660A (es) 2009-10-30
SMP200900085B (it) 2010-11-12
EP2142535A2 (en) 2010-01-13
PA8774001A1 (es) 2008-11-19
NI200900177A (es) 2010-09-09
WO2008119741A3 (en) 2008-12-04
IL200862A0 (en) 2010-05-17
AR065860A1 (es) 2009-07-08
SMAP200900085A (it) 2010-01-19
BRPI0810082A2 (pt) 2014-10-21
MA31260B1 (fr) 2010-03-01
EA200901212A1 (ru) 2010-04-30
AU2008234954B2 (en) 2011-10-27
TW200843746A (en) 2008-11-16
TN2009000388A1 (en) 2010-12-31
CA2682483A1 (en) 2008-10-09
PE20081897A1 (es) 2009-02-09
US8053457B2 (en) 2011-11-08
DOP2009000229A (es) 2009-10-31
AU2008234954A1 (en) 2008-10-09
AU2008234954B9 (en) 2012-02-02
CN101679382A (zh) 2010-03-24
UY30987A1 (es) 2008-10-31
JP2010522723A (ja) 2010-07-08
MX2009010413A (es) 2009-10-20
CR11019A (es) 2009-10-20
CL2008000899A1 (es) 2009-02-20
GT200900256A (es) 2010-03-15
WO2008119741A2 (en) 2008-10-09
KR20090122403A (ko) 2009-11-27

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