PE20081480A1 - Derivados de 8-oxoadenina como inmunomoduladores - Google Patents

Derivados de 8-oxoadenina como inmunomoduladores

Info

Publication number
PE20081480A1
PE20081480A1 PE2007001780A PE2007001780A PE20081480A1 PE 20081480 A1 PE20081480 A1 PE 20081480A1 PE 2007001780 A PE2007001780 A PE 2007001780A PE 2007001780 A PE2007001780 A PE 2007001780A PE 20081480 A1 PE20081480 A1 PE 20081480A1
Authority
PE
Peru
Prior art keywords
alkyl
alkylene
alkenyl
amino
refers
Prior art date
Application number
PE2007001780A
Other languages
English (en)
Inventor
Roger Victor Bonnert
Thomas Mcinally
Tobias Mochel
Stephen Tom
Original Assignee
Astrazeneca Ab
Dainippon Sumitomo Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Dainippon Sumitomo Pharma Co filed Critical Astrazeneca Ab
Publication of PE20081480A1 publication Critical patent/PE20081480A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, C1-C6 ALCOXI, C5-C10 HETEROARILO, ENTRE OTROS; Y1 ES UNION SIMPLE, C1-C6 ALQUILENO; X1 ES UNION SIMPLE, O, S, SO2; NR3; Z1 ES C2-C6 ALQUILENO, C3-C8 CICLOALQUILENO; X2 ES NR4, CONR4, SO2NR4, ENTRE OTROS; Y2 ES UNION SIMPLE, C1-C6 ALQUILENO; n ES 0-2; R2 ES HALOGENO, CIANO, SO2NR10R11, NR10SO2R9, ENTRE OTROS; R3 ES H, C1-C6 ALQUILO; R4 ES H, ANILLO HETEROCICLICO SATURADO DE 3-8 MIEMBROS QUE COMPRENDE UN GRUPO O, NR6; R9 ES C1-C6 ALQUILO, C2-C6 ALQUENILO, ENTRE OTROS; R10 ES H, C1-C6 ALQUILO, C2-C6 ALQUENILO, ENTRE OTROS; R11 ES H, C1-C6 ALQUILO, C3-C6 CICLOALQUILO. UN COMPUESTO PREFERIDO: 6-AMINO-9-{3-[BENCIL(3-MORFOLIN-4-ILPROPIL)AMINO]PROPIL}-2-BUTOXI-7,9-DIHIDRO-8H-PURIN-8-ONA. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON DERIVADOS DE ADENINA, MODULADORES DE LA ACTIVIDAD TLR7, UTIL EN EL TRATAMIENTO DE ENFERMEDADES ALERGICAS O VIRALES O DISTINTOS TIPOS DE CANCER
PE2007001780A 2006-12-14 2007-12-13 Derivados de 8-oxoadenina como inmunomoduladores PE20081480A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86993006P 2006-12-14 2006-12-14

Publications (1)

Publication Number Publication Date
PE20081480A1 true PE20081480A1 (es) 2008-12-07

Family

ID=39135145

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001780A PE20081480A1 (es) 2006-12-14 2007-12-13 Derivados de 8-oxoadenina como inmunomoduladores

Country Status (9)

Country Link
US (1) US8067411B2 (es)
EP (1) EP2121693B1 (es)
JP (1) JP5506393B2 (es)
AR (1) AR064345A1 (es)
CL (1) CL2007003635A1 (es)
PE (1) PE20081480A1 (es)
TW (1) TW200831105A (es)
UY (1) UY30789A1 (es)
WO (1) WO2008071976A1 (es)

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JP5329444B2 (ja) * 2007-03-19 2013-10-30 アストラゼネカ・アクチエボラーグ Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
PT2132209E (pt) * 2007-03-19 2014-04-15 Astrazeneca Ab Compostos de 8-oxo-adenina substituídos na posição 9, como moduladores do recetor de tipo ¿toll¿ (tlr7)
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PL2155743T3 (pl) 2007-05-08 2013-01-31 Astrazeneca Ab Imidazochinoliny o właściwościach immunomodulacyjnych
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