MA28684B1 - 1-aza-bicyclo[3.3.1]nonanes - Google Patents

1-aza-bicyclo[3.3.1]nonanes

Info

Publication number
MA28684B1
MA28684B1 MA29564A MA29564A MA28684B1 MA 28684 B1 MA28684 B1 MA 28684B1 MA 29564 A MA29564 A MA 29564A MA 29564 A MA29564 A MA 29564A MA 28684 B1 MA28684 B1 MA 28684B1
Authority
MA
Morocco
Prior art keywords
substituted
unsubstituted
alkyl
formula
group
Prior art date
Application number
MA29564A
Other languages
English (en)
Inventor
Dominik Feuerbach
Werner Mueller
Bernard Lucien Roy
Thomas J Troxler
Konstanze Hurth
Mathias Frederiksen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA28684B1 publication Critical patent/MA28684B1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61P25/36—Opioid-abuse
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    • A61P27/02—Ophthalmic agents
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/06—Antiarrhythmics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

L'invention concerne des dérivés de 1-aza-bicycloalkyle de formule (I), dans laquelle les substituants sont tels que définis dans la description, ainsi que des procédés de production de ces dérivés et leur utilisation dans des médicaments et des compositions pharmaceutiques. Formule (I), dans laquelle : A représente O ou N(R1) ; Y représente un groupe de formule (I), (2), (3), (4), (5) ou (6), dans laquelle la liaison gauche est fixée sur le groupe A et la liaison droite est fixée sur le groupe R ; R représente aryle C5-C10 substitué ou non substitué, hétéro-C5-C10aryle substitué ou non substitué, un groupe N(R1)(R4) OU un groupe N(R2)(CHP3R4) ; R1 représente hydrogène, alkyle C1-C4 ou CF3 ; R2 représente hydrogène, alkyle C1-C4 ou CF3 ; R3 représente hydrogène, alkyle C1-C4 ou CF3 ; R4 représente aryle C5-C10 substitué ou non substitué ou hétéroaryle C5-C10 substitué ou non substitué ; sous forme de base libre ou de sel d'addition acide.
MA29564A 2004-06-18 2006-12-28 1-aza-bicyclo[3.3.1]nonanes MA28684B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58102004P 2004-06-18 2004-06-18

Publications (1)

Publication Number Publication Date
MA28684B1 true MA28684B1 (fr) 2007-06-01

Family

ID=35045272

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29564A MA28684B1 (fr) 2004-06-18 2006-12-28 1-aza-bicyclo[3.3.1]nonanes

Country Status (33)

Country Link
US (3) US20070249657A1 (fr)
EP (2) EP1761533B8 (fr)
JP (1) JP4944772B2 (fr)
KR (3) KR20120047317A (fr)
CN (1) CN1964968A (fr)
AR (1) AR049401A1 (fr)
AT (1) ATE506362T1 (fr)
AU (1) AU2005254689B2 (fr)
BR (1) BRPI0510940A (fr)
CA (1) CA2566155C (fr)
CY (1) CY1111528T1 (fr)
DE (1) DE602005027567D1 (fr)
DK (1) DK1761533T3 (fr)
EC (1) ECSP067053A (fr)
ES (1) ES2364971T3 (fr)
HK (1) HK1107559A1 (fr)
HR (1) HRP20110535T1 (fr)
IL (2) IL179611A (fr)
MA (1) MA28684B1 (fr)
MX (1) MXPA06014697A (fr)
MY (1) MY147262A (fr)
NO (1) NO20070339L (fr)
NZ (1) NZ551198A (fr)
PE (1) PE20060437A1 (fr)
PL (1) PL1761533T3 (fr)
PT (1) PT1761533E (fr)
RU (1) RU2445313C2 (fr)
SG (1) SG153834A1 (fr)
SI (1) SI1761533T1 (fr)
TN (1) TNSN06407A1 (fr)
TW (1) TWI370128B (fr)
WO (1) WO2005123732A1 (fr)
ZA (1) ZA200609255B (fr)

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BR112013023813A2 (pt) 2011-03-18 2016-12-13 Novartis Ag combinações de ativadores do receptor acetilcolina nicotínico alfa 7 e antagonistas de mglur5 para uso em dopamina induzida por discinesia na doença de parkinson
JO3766B1 (ar) 2011-10-20 2021-01-31 Novartis Ag منشط مستقبل أسيتيل كولين الفا - 7 النيكوتيني
EP3666272A1 (fr) * 2012-05-08 2020-06-17 Forum Pharmaceuticals Inc. Utilisation de l'encénicline dans le traitement de la déficience cognitive, de la maladie d'alzheimer, du déficit de mémoire
CA2890018A1 (fr) * 2012-11-05 2014-05-08 Nant Holdings Ip, Llc Derives indol-5-ole substitues et leurs applications therapeutiques
CA2894384C (fr) 2012-12-11 2018-03-06 Novartis Ag Biomarqueur de prediction de la sensibilite a un traitement par un activateur du recepteur alpha 7 nicotinique de l'acetylcholine
JP6338223B2 (ja) * 2013-01-15 2018-06-06 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アゴニストの使用
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
WO2014111751A1 (fr) 2013-01-15 2014-07-24 Novartis Ag Utilisation d'agonistes du récepteur nicotinique alpha 7 pour le traitement de la narcolepsie
KR101879919B1 (ko) * 2013-01-15 2018-07-18 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
WO2019028440A1 (fr) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. Méthodes et compositions permettant de moduler l'épissageé
WO2020163405A1 (fr) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Procédés et compositions pour moduler l'épissage
KR20210135507A (ko) 2019-02-06 2021-11-15 스카이호크 테라퓨틱스, 인코포레이티드 스플라이싱을 조절하는 방법 및 조성물

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IL225968A0 (en) 2013-06-27
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