NO20070339L - 1-aza-bicyklo[3 3.1]nonaner - Google Patents

1-aza-bicyklo[3 3.1]nonaner

Info

Publication number
NO20070339L
NO20070339L NO20070339A NO20070339A NO20070339L NO 20070339 L NO20070339 L NO 20070339L NO 20070339 A NO20070339 A NO 20070339A NO 20070339 A NO20070339 A NO 20070339A NO 20070339 L NO20070339 L NO 20070339L
Authority
NO
Norway
Prior art keywords
aza
nonanes
bicyclo
pharmaceuticals
substituents
Prior art date
Application number
NO20070339A
Other languages
English (en)
Inventor
Thomas J Troxler
Dominik Feuerbach
Werner Mueller
Bernard Lucien Roy
Konstanze Hurth
Mathias Frederiksen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20070339L publication Critical patent/NO20070339L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen angår 1-aza-bisykloalkylderivater med formelen (I) der substituentene er som definert i spesifikasjonen, fremgangsmåte for deres produksjon, deres anvendelse som legemidler og til farmasøytiske sammensetninger som omfatter dem.
NO20070339A 2004-06-18 2007-01-18 1-aza-bicyklo[3 3.1]nonaner NO20070339L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58102004P 2004-06-18 2004-06-18
PCT/EP2005/006566 WO2005123732A1 (en) 2004-06-18 2005-06-17 1-aza-bicyclo[3.3.1]nonanes

Publications (1)

Publication Number Publication Date
NO20070339L true NO20070339L (no) 2007-03-19

Family

ID=35045272

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070339A NO20070339L (no) 2004-06-18 2007-01-18 1-aza-bicyklo[3 3.1]nonaner

Country Status (33)

Country Link
US (3) US20070249657A1 (no)
EP (2) EP2336129A1 (no)
JP (1) JP4944772B2 (no)
KR (3) KR101343654B1 (no)
CN (1) CN1964968A (no)
AR (1) AR049401A1 (no)
AT (1) ATE506362T1 (no)
AU (1) AU2005254689B2 (no)
BR (1) BRPI0510940A (no)
CA (1) CA2566155C (no)
CY (1) CY1111528T1 (no)
DE (1) DE602005027567D1 (no)
DK (1) DK1761533T3 (no)
EC (1) ECSP067053A (no)
ES (1) ES2364971T3 (no)
HK (1) HK1107559A1 (no)
HR (1) HRP20110535T1 (no)
IL (2) IL179611A (no)
MA (1) MA28684B1 (no)
MX (1) MXPA06014697A (no)
MY (1) MY147262A (no)
NO (1) NO20070339L (no)
NZ (1) NZ551198A (no)
PE (1) PE20060437A1 (no)
PL (1) PL1761533T3 (no)
PT (1) PT1761533E (no)
RU (1) RU2445313C2 (no)
SG (1) SG153834A1 (no)
SI (1) SI1761533T1 (no)
TN (1) TNSN06407A1 (no)
TW (1) TWI370128B (no)
WO (1) WO2005123732A1 (no)
ZA (1) ZA200609255B (no)

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AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
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TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
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CA2830458A1 (en) * 2011-03-18 2012-09-27 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mglur5 antagonists for use in dopamine induced dyskinesia in parkinson's disease
EP2768507B1 (en) 2011-10-20 2019-12-11 Novartis AG Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
RU2635522C2 (ru) * 2012-05-08 2017-11-13 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
CN104955459B (zh) * 2012-11-05 2019-02-01 南特知识产权控股有限责任公司 取代的吲哚-5-酚衍生物及其治疗应用
KR102043309B1 (ko) 2012-12-11 2019-11-11 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 활성화제 치료에 대한 반응성의 예측 바이오마커
BR112015016995B8 (pt) 2013-01-15 2022-07-26 Novartis Ag Uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
WO2014111751A1 (en) 2013-01-15 2014-07-24 Novartis Ag Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
BR112015016992A8 (pt) 2013-01-15 2018-01-23 Novartis Ag uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
CN111499615B (zh) 2017-08-04 2024-02-02 斯基霍克疗法公司 用于调节剪接的方法和组合物
EP3920915A4 (en) 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
EP3920928A4 (en) 2019-02-06 2022-09-28 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING

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