BR0307874A - Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7 - Google Patents

Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7

Info

Publication number
BR0307874A
BR0307874A BR0307874-4A BR0307874A BR0307874A BR 0307874 A BR0307874 A BR 0307874A BR 0307874 A BR0307874 A BR 0307874A BR 0307874 A BR0307874 A BR 0307874A
Authority
BR
Brazil
Prior art keywords
alpha7
compounds
activity
nicotinically
ring system
Prior art date
Application number
BR0307874-4A
Other languages
English (en)
Inventor
Eric Jon Jacobsen
Jason Kenneth Myers
Steven Charles Reitz
Brad A Acker
Daniel Patrick Walker
Donn Gregory Wishka
David Walter Piotrowski
Vincent Edward Groppi Jr
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR0307874A publication Critical patent/BR0307874A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"ATIVIDADE DE COMPOSTOS AZABICìCLICOS COM RECEPTOR DE ACETILCOLINA NICOTìNICA ALFA7". A presente invenção refere-se a compostos da Fórmula I: Fórmula I em que azabicicio é (2) W representa um sistema de anel heterocíclico de 6 membros tendo 1-2 átomos de nitrogênio ou um sistema de anéis fundidos de 10 membros bicíclico-seis-seis tendo até dois átomos de nitrogênio dentro de um ou em ambos os anéis, desde que nenhum nitrogênio esteja em uma ponte do sistema de anéis fundidos bicíclico-seis-seis, e tendo ainda 1-2 substituintes selecionados independentemente a partir de R~ 3~. Estes compostos podem estar na forma de sais ou composições, podem estar em forma enantiomérica pura ou como misturas racêmicas, e são úteis em produtos farmacêuticos para tratar doenças ou condições nos quais se sabe que <244>7 está envolvido.
BR0307874-4A 2002-02-20 2003-02-14 Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7 BR0307874A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35814602P 2002-02-20 2002-02-20
PCT/US2003/002688 WO2003072578A1 (en) 2002-02-20 2003-02-14 Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity

Publications (1)

Publication Number Publication Date
BR0307874A true BR0307874A (pt) 2004-12-28

Family

ID=27765951

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307874-4A BR0307874A (pt) 2002-02-20 2003-02-14 Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7

Country Status (8)

Country Link
US (1) US7001900B2 (pt)
EP (1) EP1478646A1 (pt)
JP (1) JP2005525357A (pt)
AU (1) AU2003214936A1 (pt)
BR (1) BR0307874A (pt)
CA (1) CA2475773A1 (pt)
MX (1) MXPA04007083A (pt)
WO (1) WO2003072578A1 (pt)

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Also Published As

Publication number Publication date
US7001900B2 (en) 2006-02-21
AU2003214936A1 (en) 2003-09-09
WO2003072578A1 (en) 2003-09-04
CA2475773A1 (en) 2003-09-04
JP2005525357A (ja) 2005-08-25
US20030236270A1 (en) 2003-12-25
MXPA04007083A (es) 2004-10-29
EP1478646A1 (en) 2004-11-24

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