PE20110777A1 - Nuevas lactamas como inhibidores de beta secretasa - Google Patents
Nuevas lactamas como inhibidores de beta secretasaInfo
- Publication number
- PE20110777A1 PE20110777A1 PE2011001066A PE2011001066A PE20110777A1 PE 20110777 A1 PE20110777 A1 PE 20110777A1 PE 2011001066 A PE2011001066 A PE 2011001066A PE 2011001066 A PE2011001066 A PE 2011001066A PE 20110777 A1 PE20110777 A1 PE 20110777A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- alkyl
- halogen
- secretase inhibitors
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ESPIROPIPERIDINA DE FORMULA (I) DONDE B ES ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON R3, EN DONDE R3 ES HALOGENO, CN, OH, ENTRE OTROS; A ES ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON R4, EN DONDE R4 ES ALQUILO, HALOGENO, CN, ENTRE OTROS; CUANDO ---- ES UN ENLACE SENCILLO R1a Y R1b SON CADA UNO H, ALQUILO, ALQUENILO, ENTRE OTROS; Y CUANDO ---- ES UN DOBLE ENLACE R1b ESTA AUSENTE Y R1a ES H, ALQUILO, (CH2)t-CICLOALQUILO, ENTRE OTROS, DONDE t ES DE 0 A 3; n ES DE 1 A 3; R2 ES ALQUILO, CICLOALQUILO O ALQUENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH O CN. SON COMPUESTOS PREFERIDOS: (5R,7S)-8-(4-HIDROXI-3-ISOPROPOXI-BENCIL)-7-METIL-1-FENIL-1,8-DIAZA-ESPIRO[4,5]DECAN-2-ONA; N-{4-[(5R,7S)-8-(4-HIDROXI-3-ISOPROPOXI-BENCIL)-7-METIL-2-OXO-1,8-DIAZA-ESPIRO[4,5]DEC-1-IL]-FENIL}-ACETAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA BETA-SECRETASA (BACE) SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ISQUEMIA CEREBRAL, DEMENCIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11722508P | 2008-11-23 | 2008-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110777A1 true PE20110777A1 (es) | 2011-10-29 |
Family
ID=41481076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001066A PE20110777A1 (es) | 2008-11-23 | 2009-11-12 | Nuevas lactamas como inhibidores de beta secretasa |
Country Status (28)
Country | Link |
---|---|
US (1) | US20110224231A1 (es) |
EP (1) | EP2370439A1 (es) |
JP (2) | JP4932065B2 (es) |
KR (1) | KR20110086769A (es) |
CN (1) | CN102317289A (es) |
AP (1) | AP2011005725A0 (es) |
AU (1) | AU2009318855A1 (es) |
BR (1) | BRPI0922799A2 (es) |
CA (1) | CA2743584A1 (es) |
CL (1) | CL2011001147A1 (es) |
CO (1) | CO6361924A2 (es) |
CR (1) | CR20110269A (es) |
CU (1) | CU20110113A7 (es) |
DO (1) | DOP2011000134A (es) |
EA (1) | EA201170722A1 (es) |
EC (1) | ECSP11011073A (es) |
GE (1) | GEP20135806B (es) |
IL (1) | IL212869A0 (es) |
MA (1) | MA32929B1 (es) |
MX (1) | MX2011005346A (es) |
NI (1) | NI201100096A (es) |
NZ (1) | NZ592823A (es) |
PE (1) | PE20110777A1 (es) |
SV (1) | SV2011003916A (es) |
TN (1) | TN2011000252A1 (es) |
UA (1) | UA99787C2 (es) |
WO (1) | WO2010058333A1 (es) |
ZA (1) | ZA201103738B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
AR075854A1 (es) | 2009-03-13 | 2011-05-04 | Vitae Pharmaceuticals Inc | Inhibidores de beta- secretasa |
AU2010294214B2 (en) | 2009-09-11 | 2015-05-07 | Vivoryon Therapeutics N.V. | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
EP3372580B1 (de) * | 2011-01-25 | 2020-07-22 | Bayer CropScience Aktiengesellschaft | Verfahren zur herstellung von 1-h-pyrrolidin-2,4-dion-derivaten |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
TWI557112B (zh) * | 2012-03-05 | 2016-11-11 | 百靈佳殷格翰國際股份有限公司 | β-分泌酶抑制劑 |
EP2900650A1 (en) | 2012-09-28 | 2015-08-05 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
US9926317B2 (en) | 2014-07-14 | 2018-03-27 | Merck Sharp Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2016008064A1 (en) * | 2014-07-14 | 2016-01-21 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
EP3233799B1 (en) | 2014-12-19 | 2021-05-19 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
CN113045484B (zh) * | 2019-12-27 | 2024-01-26 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876260A (en) * | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
FR2824901B1 (fr) * | 2001-05-21 | 2003-09-12 | Poudres & Explosifs Ste Nale | Procede et installation de destruction de fusee montee sur une munition |
PL380482A1 (pl) * | 2003-12-22 | 2007-02-05 | Schering Corporation | Farmaceutyczne kompozycje |
CA2554920C (en) * | 2004-02-17 | 2011-12-06 | Herm. Sprenger Gmbh & Co. Kg | Double-jointed bit for horses |
JP2008515895A (ja) * | 2004-10-07 | 2008-05-15 | メルク エンド カムパニー インコーポレーテッド | Cgrp受容体拮抗薬 |
CA2583342A1 (en) * | 2004-10-13 | 2006-04-27 | Merck And Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease |
GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
EP1885713A1 (en) * | 2005-05-18 | 2008-02-13 | Pfizer Limited | 1, 2, 4 -triazole derivatives as vasopressin antagonists |
WO2007011810A1 (en) * | 2005-07-18 | 2007-01-25 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
BRPI0520556A2 (pt) * | 2005-09-20 | 2009-05-12 | Sca Hygiene Prod Ab | distribuidor |
WO2007139833A2 (en) * | 2006-05-26 | 2007-12-06 | Eisai R & D Management Co., Ltd | Imidazoazephinone compounds |
MX2008015037A (es) * | 2006-05-26 | 2008-12-10 | Eisai R&D Man Co Ltd | Compuestos de imidazoazepinona. |
WO2007143847A1 (en) * | 2006-06-14 | 2007-12-21 | Virochem Pharma Inc. | Spirotropane compounds |
AU2007293416A1 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
AU2007307170A1 (en) * | 2006-10-06 | 2008-04-17 | Merck & Co., Inc. | Macrocyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
EP2091328B1 (en) * | 2006-10-30 | 2011-12-28 | Merck Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
-
2009
- 2009-11-12 PE PE2011001066A patent/PE20110777A1/es not_active Application Discontinuation
- 2009-11-12 MA MA33879A patent/MA32929B1/fr unknown
- 2009-11-12 AU AU2009318855A patent/AU2009318855A1/en not_active Abandoned
- 2009-11-12 EP EP09764055A patent/EP2370439A1/en not_active Withdrawn
- 2009-11-12 MX MX2011005346A patent/MX2011005346A/es not_active Application Discontinuation
- 2009-11-12 CN CN2009801552711A patent/CN102317289A/zh active Pending
- 2009-11-12 EA EA201170722A patent/EA201170722A1/ru unknown
- 2009-11-12 UA UAA201106359A patent/UA99787C2/ru unknown
- 2009-11-12 KR KR1020117014375A patent/KR20110086769A/ko active IP Right Grant
- 2009-11-12 NZ NZ592823A patent/NZ592823A/xx not_active IP Right Cessation
- 2009-11-12 GE GEAP200912232A patent/GEP20135806B/en unknown
- 2009-11-12 WO PCT/IB2009/055043 patent/WO2010058333A1/en active Application Filing
- 2009-11-12 JP JP2011536976A patent/JP4932065B2/ja not_active Expired - Fee Related
- 2009-11-12 AP AP2011005725A patent/AP2011005725A0/xx unknown
- 2009-11-12 BR BRPI0922799A patent/BRPI0922799A2/pt not_active IP Right Cessation
- 2009-11-12 US US13/130,192 patent/US20110224231A1/en not_active Abandoned
- 2009-11-12 CA CA2743584A patent/CA2743584A1/en not_active Abandoned
-
2011
- 2011-05-11 NI NI201100096A patent/NI201100096A/es unknown
- 2011-05-12 IL IL212869A patent/IL212869A0/en unknown
- 2011-05-12 DO DO2011000134A patent/DOP2011000134A/es unknown
- 2011-05-17 TN TN2011000252A patent/TN2011000252A1/fr unknown
- 2011-05-17 CU CU20110113A patent/CU20110113A7/es unknown
- 2011-05-17 CL CL2011001147A patent/CL2011001147A1/es unknown
- 2011-05-20 ZA ZA2011/03738A patent/ZA201103738B/en unknown
- 2011-05-23 CR CR20110269A patent/CR20110269A/es not_active Application Discontinuation
- 2011-05-23 SV SV2011003916A patent/SV2011003916A/es unknown
- 2011-05-23 EC EC2011011073A patent/ECSP11011073A/es unknown
- 2011-05-24 CO CO11063882A patent/CO6361924A2/es not_active Application Discontinuation
-
2012
- 2012-01-20 JP JP2012009735A patent/JP2012107029A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP4932065B2 (ja) | 2012-05-16 |
CU20110113A7 (es) | 2012-01-31 |
CL2011001147A1 (es) | 2011-09-30 |
SV2011003916A (es) | 2011-07-28 |
MA32929B1 (fr) | 2012-01-02 |
BRPI0922799A2 (pt) | 2019-09-24 |
ECSP11011073A (es) | 2011-06-30 |
ZA201103738B (en) | 2012-01-25 |
AU2009318855A1 (en) | 2010-05-27 |
KR20110086769A (ko) | 2011-07-29 |
UA99787C2 (en) | 2012-09-25 |
WO2010058333A1 (en) | 2010-05-27 |
GEP20135806B (en) | 2013-04-10 |
EP2370439A1 (en) | 2011-10-05 |
AP2011005725A0 (en) | 2011-06-30 |
NI201100096A (es) | 2011-10-31 |
CO6361924A2 (es) | 2012-01-20 |
MX2011005346A (es) | 2011-06-16 |
CN102317289A (zh) | 2012-01-11 |
CR20110269A (es) | 2011-07-04 |
EA201170722A1 (ru) | 2011-10-31 |
IL212869A0 (en) | 2011-07-31 |
JP2012509310A (ja) | 2012-04-19 |
NZ592823A (en) | 2012-12-21 |
DOP2011000134A (es) | 2011-07-31 |
CA2743584A1 (en) | 2010-05-27 |
JP2012107029A (ja) | 2012-06-07 |
TN2011000252A1 (fr) | 2012-12-17 |
US20110224231A1 (en) | 2011-09-15 |
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