PE20090248A1 - Moduladores de beta-amiloide - Google Patents

Moduladores de beta-amiloide

Info

Publication number
PE20090248A1
PE20090248A1 PE2008000822A PE2008000822A PE20090248A1 PE 20090248 A1 PE20090248 A1 PE 20090248A1 PE 2008000822 A PE2008000822 A PE 2008000822A PE 2008000822 A PE2008000822 A PE 2008000822A PE 20090248 A1 PE20090248 A1 PE 20090248A1
Authority
PE
Peru
Prior art keywords
methyl
phenyl
beta
metoxy
hetaryl
Prior art date
Application number
PE2008000822A
Other languages
English (en)
Inventor
Karlheinz Baumann
Alexander Flohr
Helmut Jacobsen
Synese Jolidon
Thomas Luebbers
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090248A1 publication Critical patent/PE20090248A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA I, EN LA QUE HETARILO I ES a), b) O c); HETARILO II ES d), e) O f); R1 ES H, ALCOXI INFERIOR O CIANO; R2 Y R3 SON H, ALQUILO INFERIOR, -CH2-C(O)-PIPERIDIN-1-ILO, ENTRE OTROS; R4 ES H, -C(O)-FENILO OPCIONALMENTE SUSTUIDO POR HALOGENO, -CH2-CH2-FENILO, ENTRE OTROS; R5 ES H, HALOGENO O ALQUILO INFERIOR; n ES 0 O 1. SON SELECCIONADOS [5-(3-CLORO-BENCIL)-4-METIL-TIAZOL-2-IL]-[3-METOXI-4-(4-METIL-IMIDAZOL-1-IL)-FENIL]-AMINA, 2-METOXI-1-{2-[3-METOXI-4-(4-METIL-IMIDAZOL-1-IL)-FENILAMINO]-6,7-DIHIDRO-4H-TIAZOLO[5,4-c]PIRIDIN-5-IL}-ETANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES BETA AMILOIDE, UTILES EN EL TRATAMIENTO DE ALZHEIMER, ANGIOPATIA CEREBRAL AMILOIDE, HCHWA-D, DEMENCIA MULTIINFARTO O PUGILISTICA O SINDROME DE DOWN
PE2008000822A 2007-05-11 2008-05-09 Moduladores de beta-amiloide PE20090248A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07108004 2007-05-11

Publications (1)

Publication Number Publication Date
PE20090248A1 true PE20090248A1 (es) 2009-03-27

Family

ID=39758855

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000822A PE20090248A1 (es) 2007-05-11 2008-05-09 Moduladores de beta-amiloide

Country Status (20)

Country Link
US (1) US7910740B2 (es)
EP (1) EP2155740B1 (es)
JP (1) JP5264890B2 (es)
KR (1) KR101138045B1 (es)
CN (1) CN101675045B (es)
AR (1) AR066509A1 (es)
AT (1) ATE496915T1 (es)
AU (1) AU2008250436B2 (es)
BR (1) BRPI0811993A2 (es)
CA (1) CA2686754C (es)
CL (1) CL2008001347A1 (es)
DE (1) DE602008004769D1 (es)
ES (1) ES2358863T3 (es)
IL (1) IL201566A (es)
MX (1) MX2009012163A (es)
PE (1) PE20090248A1 (es)
RU (1) RU2009140182A (es)
TW (1) TW200904420A (es)
WO (1) WO2008138753A1 (es)
ZA (1) ZA200907585B (es)

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JP5221144B2 (ja) * 2005-11-24 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 モルホリンタイプ・シンナミド化合物
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CA2694401C (en) 2007-08-31 2012-12-04 Eisai R&D Management Co., Ltd. Polycyclic compound
JP5395808B2 (ja) * 2007-12-21 2014-01-22 エフ．ホフマン−ラ ロシュ アーゲー オレキシン受容体アンタゴニストとしてのヘテロアリール誘導体
KR101244517B1 (ko) 2008-01-11 2013-03-18 에프. 호프만-라 로슈 아게 아밀로이드 베타에 대한 조절제
CA2712095A1 (en) * 2008-01-28 2009-08-06 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
MX2010008700A (es) * 2008-02-22 2010-08-30 Hoffmann La Roche Moduladores de beta-amiloide.
AU2009301210B2 (en) * 2008-10-09 2014-05-15 F. Hoffmann-La Roche Ag Modulators for amyloid beta
CN102272133A (zh) * 2008-11-06 2011-12-07 阿斯利康(瑞典)有限公司 淀粉样β的调节剂
MX2011004954A (es) * 2008-11-10 2011-05-30 Hoffmann La Roche Moduladores heterociclicos de gamma-secretasa.
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TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
US8835482B2 (en) * 2009-05-07 2014-09-16 Janssen Pharmaceuticals, Inc. Substituted indazole and aza-indazole derivatives as gamma secretase modulators
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
US8946266B2 (en) 2009-07-15 2015-02-03 Janssen Pharmaceuticals, Inc. Substituted triazole and imidazole derivatives as gamma secretase modulators
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JP6106745B2 (ja) 2012-05-16 2017-04-05 ヤンセン ファーマシューティカルズ，インコーポレーテッド （特に）アルツハイマー病の治療に有用な置換３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
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CN103664819A (zh) * 2013-12-16 2014-03-26 山东汇海医药化工有限公司 一种2-氨基-4-甲基噻唑-5-甲酸乙酯的制备方法
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
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Also Published As

Publication number Publication date
KR101138045B1 (ko) 2012-04-24
ZA200907585B (en) 2010-07-28
AU2008250436B2 (en) 2013-03-28
MX2009012163A (es) 2009-12-01
RU2009140182A (ru) 2011-06-20
ES2358863T3 (es) 2011-05-16
JP2010526847A (ja) 2010-08-05
CL2008001347A1 (es) 2009-05-29
CN101675045B (zh) 2012-11-28
AU2008250436A1 (en) 2008-11-20
EP2155740B1 (en) 2011-01-26
KR20100008791A (ko) 2010-01-26
US7910740B2 (en) 2011-03-22
EP2155740A1 (en) 2010-02-24
CA2686754C (en) 2014-10-28
DE602008004769D1 (en) 2011-03-10
CA2686754A1 (en) 2008-11-20
BRPI0811993A2 (pt) 2014-11-18
IL201566A0 (en) 2010-05-31
WO2008138753A1 (en) 2008-11-20
JP5264890B2 (ja) 2013-08-14
CN101675045A (zh) 2010-03-17
TW200904420A (en) 2009-02-01
US20080280948A1 (en) 2008-11-13
AR066509A1 (es) 2009-08-26
ATE496915T1 (de) 2011-02-15
IL201566A (en) 2013-08-29

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