PE20110773A1 - Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, y su preparacion - Google Patents
Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, y su preparacionInfo
- Publication number
- PE20110773A1 PE20110773A1 PE2011001127A PE2011001127A PE20110773A1 PE 20110773 A1 PE20110773 A1 PE 20110773A1 PE 2011001127 A PE2011001127 A PE 2011001127A PE 2011001127 A PE2011001127 A PE 2011001127A PE 20110773 A1 PE20110773 A1 PE 20110773A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidinone
- decan
- ona
- aza
- oxa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE TETRAHIDROPIRAN ESPIRO PIRROLIDINONA Y PIPERIDINONA SUSTITUIDOS DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C4), CF3 O ALCOXI(C1-C4)-ALQUILO(C1-C4); R2 ES H, HALOGENO, ALQUILO(C1-C4) O CF3; m, n Y p SON CADA UNO 1 O 2. SON COMPUESTOS PREFERIDOS: 2-[4-((2S,3'S)-2-METIL-[1,3']BIPIRROLIDINIL-1'-IL)-FENIL]-8-OXA-2-AZA-ESPIRO[4.5]DECAN-1-ONA; 2-{2-METIL-4-[4-((S)-2-METIL-PIRROLIDIN-1-IL)-PIPERIDIN-1-IL]-FENIL}-8-OXA-2-AZA-ESPIRO[4.5]DECAN-1-ONA; 2-[2-FLUORO-4-(2-ISOPROPIL-[1,3']BIPIRROLIDINIL-1'-IL)-FENIL]-8-OXA-2-AZA-ESPIRO[4.5]DECAN-1-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES DE HISTAMINA H3 SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, EPILEPSIA, INSOMNIO
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12008708P | 2008-12-05 | 2008-12-05 | |
FR0955909 | 2009-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110773A1 true PE20110773A1 (es) | 2011-10-26 |
Family
ID=41665099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001127A PE20110773A1 (es) | 2008-12-05 | 2009-12-04 | Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, y su preparacion |
Country Status (27)
Country | Link |
---|---|
US (2) | US8217052B2 (es) |
EP (1) | EP2373659B1 (es) |
JP (1) | JP5410544B2 (es) |
KR (1) | KR101682889B1 (es) |
CN (1) | CN102239170B (es) |
AR (1) | AR074467A1 (es) |
AU (1) | AU2009322243B2 (es) |
CA (1) | CA2745715C (es) |
CO (1) | CO6390059A2 (es) |
CR (1) | CR20110289A (es) |
DO (1) | DOP2011000166A (es) |
EC (1) | ECSP11011109A (es) |
ES (1) | ES2507574T3 (es) |
HN (1) | HN2011001487A (es) |
IL (1) | IL213292A (es) |
MA (1) | MA32945B1 (es) |
MX (1) | MX2011004791A (es) |
MY (1) | MY150789A (es) |
NZ (1) | NZ593150A (es) |
PA (1) | PA8852301A1 (es) |
PE (1) | PE20110773A1 (es) |
RU (1) | RU2519778C2 (es) |
TN (1) | TN2011000223A1 (es) |
TW (1) | TWI441826B (es) |
UA (1) | UA104880C2 (es) |
WO (1) | WO2010065798A1 (es) |
ZA (1) | ZA201103261B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
TW201206444A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
EP2569296A1 (en) * | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
TW201206889A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
JP5968307B2 (ja) * | 2010-05-11 | 2016-08-10 | サノフイ | 置換フェニルシクロアルキルピロリジン(ピペリジン)スピロラクタム類及びアミド類、それらの製造及び治療的使用 |
JP2013529198A (ja) | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたn−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3256276A (en) * | 1961-02-17 | 1966-06-14 | Geschickter Fund Med Res | Substituted spiroimides |
US3258276A (en) | 1964-04-06 | 1966-06-28 | Charles E Murcott | Utility chair |
WO2003031432A1 (en) * | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
US6889262B1 (en) | 2002-06-26 | 2005-05-03 | Advanced Micro Devices, Inc. | Direct transaction mode for peripheral devices |
AU2003287206A1 (en) * | 2002-10-23 | 2004-05-13 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
ATE547404T1 (de) * | 2003-09-22 | 2012-03-15 | Msd Kk | Piperidinderivate |
CN101263112B (zh) * | 2005-07-01 | 2012-10-10 | 伊莱利利公司 | 组胺h3受体药物、其制备和治疗用途 |
NZ568292A (en) * | 2005-11-10 | 2011-08-26 | Msd Kk | Spiro[cyclohexane-1,1'-(3'H)-4'-azaisobenzofuran]-4-carboxamide derivatives |
CN101331131A (zh) | 2005-12-16 | 2008-12-24 | 霍夫曼-拉罗奇有限公司 | 用作H3受体调节剂的吡咯并[2,3-b]吡啶衍生物 |
US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
JP2009537596A (ja) * | 2006-05-23 | 2009-10-29 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 6−(4−シクロプロピルピペリジン−1−イル)−2’−メチル−[3,4’]−ビピリジン及びその医薬としての使用 |
US7479493B2 (en) | 2006-06-29 | 2009-01-20 | Janssen Pharmaceutica N.V. | Substituted benzyl amine compounds |
WO2009039431A2 (en) | 2007-09-21 | 2009-03-26 | Neurogen Corporation | Substituted aryl-fused spirocyclic amines |
PT2205558E (pt) | 2007-10-17 | 2012-11-02 | Sanofi Sa | Amidas de n-fenil-pirrolidinilmetilpirrolidina substituídas e sua utilização terapêutica como moduladores do receptor h3 da histamina |
RU2477719C2 (ru) | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилбипирролидинкарбоксамиды и их терапевтическое применение |
MX2010003949A (es) * | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. |
AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
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2009
- 2009-12-03 AR ARP090104667A patent/AR074467A1/es unknown
- 2009-12-04 EP EP09775421.2A patent/EP2373659B1/en active Active
- 2009-12-04 PA PA20098852301A patent/PA8852301A1/es unknown
- 2009-12-04 NZ NZ593150A patent/NZ593150A/xx not_active IP Right Cessation
- 2009-12-04 TW TW098141444A patent/TWI441826B/zh not_active IP Right Cessation
- 2009-12-04 ES ES09775421.2T patent/ES2507574T3/es active Active
- 2009-12-04 KR KR1020117014404A patent/KR101682889B1/ko active IP Right Grant
- 2009-12-04 MY MYPI20112068 patent/MY150789A/en unknown
- 2009-12-04 WO PCT/US2009/066666 patent/WO2010065798A1/en active Application Filing
- 2009-12-04 CA CA2745715A patent/CA2745715C/en not_active Expired - Fee Related
- 2009-12-04 RU RU2011127382/04A patent/RU2519778C2/ru not_active IP Right Cessation
- 2009-12-04 PE PE2011001127A patent/PE20110773A1/es not_active Application Discontinuation
- 2009-12-04 MA MA33989A patent/MA32945B1/fr unknown
- 2009-12-04 MX MX2011004791A patent/MX2011004791A/es active IP Right Grant
- 2009-12-04 CN CN200980148490.7A patent/CN102239170B/zh active Active
- 2009-12-04 AU AU2009322243A patent/AU2009322243B2/en not_active Ceased
- 2009-12-04 JP JP2011539715A patent/JP5410544B2/ja active Active
- 2009-12-04 UA UAA201108412A patent/UA104880C2/uk unknown
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2011
- 2011-05-05 ZA ZA2011/03261A patent/ZA201103261B/en unknown
- 2011-05-06 TN TN2011000223A patent/TN2011000223A1/fr unknown
- 2011-05-27 CR CR20110289A patent/CR20110289A/es unknown
- 2011-05-31 IL IL213292A patent/IL213292A/en not_active IP Right Cessation
- 2011-06-01 DO DO2011000166A patent/DOP2011000166A/es unknown
- 2011-06-02 US US13/151,925 patent/US8217052B2/en active Active
- 2011-06-02 CO CO11068492A patent/CO6390059A2/es active IP Right Grant
- 2011-06-03 EC EC2011011109A patent/ECSP11011109A/es unknown
- 2011-06-03 HN HN2011001487A patent/HN2011001487A/es unknown
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2012
- 2012-05-30 US US13/483,503 patent/US8383814B2/en active Active
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FD | Application declared void or lapsed |