PE20120261A1 - Piperidina espiro pirrolidinona y piperidinonas sustitudos como moduladores de los receptores h3 - Google Patents

Piperidina espiro pirrolidinona y piperidinonas sustitudos como moduladores de los receptores h3

Info

Publication number
PE20120261A1
PE20120261A1 PE2011001148A PE2011001148A PE20120261A1 PE 20120261 A1 PE20120261 A1 PE 20120261A1 PE 2011001148 A PE2011001148 A PE 2011001148A PE 2011001148 A PE2011001148 A PE 2011001148A PE 20120261 A1 PE20120261 A1 PE 20120261A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
modulators
receptors
diaza
Prior art date
Application number
PE2011001148A
Other languages
English (en)
Inventor
Zhongli Gao
Daniel Hall
Ryan Hartung
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PE20120261A1 publication Critical patent/PE20120261A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO PIPERIDINA ESPIRO PIRROLIDONA Y PIPERIDINONA DE FORMULA (I), DONDE m, n Y p SON 1 O 2; R1 ES H, ALQUILO C1-C4, CF3, ALCOXI C1-C4-ALQUILO C1-C4; R2 ES H, HALOGENO, ALQUILO C1-C4, CF3; R3 ES H, ALQUILO C1-C4, ALQUILOXICARBONILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ESTER TERC-BUTILICO DE ACIDO 2-[2-METIL-4-((2R,3'S)-2-METIL-[1,3']BIPIRROLIDINIL-1'-IL)-FENIL]-1-OXO-2,8-DIAZA-ESPIRO[4.5]DECANO-8-CARBOXILICO, ESTER TERC-BUTILICO DE ACIDO 2-[2-METIL-4-((2S,3'S)-2-METIL-[1,3']BIPIRROLIDINIL-1'-IL)-FENIL]-1-OXO-2,9-DIAZA-ESPIRO[5.5]UNDECANO-9-CARBOXILICO, ESTER TERC-BUTILICO DE ACIDO 2-{4-[4-(2S-2-METIL-PIRROLIDIN-1-IL)-PIPERIDINIL-1-IL]-FENIL}-1-OXO-2,8-DIAZA-ESPIRO[4.5]DECANO-8-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES H3 DE HISTAMINA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SUENO, ESCLEROSIS MULTIPLE, TRASTORNO COGNITIVO, DEMENCIA, ENTRE OTROS
PE2011001148A 2008-12-05 2009-12-04 Piperidina espiro pirrolidinona y piperidinonas sustitudos como moduladores de los receptores h3 PE20120261A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12008808P 2008-12-05 2008-12-05
FR0955431 2009-07-31

Publications (1)

Publication Number Publication Date
PE20120261A1 true PE20120261A1 (es) 2012-04-04

Family

ID=41647030

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001148A PE20120261A1 (es) 2008-12-05 2009-12-04 Piperidina espiro pirrolidinona y piperidinonas sustitudos como moduladores de los receptores h3

Country Status (24)

Country Link
US (2) US8227481B2 (es)
EP (1) EP2373652B1 (es)
JP (1) JP5538421B2 (es)
KR (1) KR101687216B1 (es)
CN (1) CN102239168B (es)
AR (1) AR074466A1 (es)
AU (1) AU2009322248B2 (es)
CA (1) CA2745721C (es)
CO (1) CO6390058A2 (es)
CR (1) CR20110294A (es)
DK (1) DK2373652T3 (es)
EC (1) ECSP11011108A (es)
ES (1) ES2441221T3 (es)
IL (1) IL213290A (es)
MA (1) MA32943B1 (es)
MX (1) MX2011004939A (es)
NZ (1) NZ593151A (es)
PE (1) PE20120261A1 (es)
PT (1) PT2373652E (es)
RU (1) RU2011127401A (es)
TN (1) TN2011000233A1 (es)
TW (1) TWI481609B (es)
WO (1) WO2010065803A1 (es)
ZA (1) ZA201103448B (es)

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AR074467A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
TW201206444A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
AR081382A1 (es) 2010-05-11 2012-08-29 Sanofi Aventis Derivados de n-heterocicloalquil bipirrolidinilfenil amida sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central.
WO2011143150A1 (en) 2010-05-11 2011-11-17 Sanofi Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
EP2569303A1 (en) 2010-05-11 2013-03-20 Sanofi Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
JP5833105B2 (ja) * 2010-05-11 2015-12-16 サノフイ 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用
TW201206901A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
WO2011143163A1 (en) * 2010-05-11 2011-11-17 Sanofi Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof
US9708270B2 (en) 2012-10-11 2017-07-18 Merck Sharp & Dohme Corp. Substituted spiropiperidinyl compounds useful as GPR120 agonists
US9197285B2 (en) * 2012-12-20 2015-11-24 Deere & Company Methods and apparatus for ameliorating signal reception
CN111278825B (zh) * 2017-11-03 2023-05-02 百时美施贵宝公司 二氮杂螺rock抑制剂

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AR074467A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.

Also Published As

Publication number Publication date
AR074466A1 (es) 2011-01-19
TWI481609B (zh) 2015-04-21
JP5538421B2 (ja) 2014-07-02
IL213290A0 (en) 2011-07-31
NZ593151A (en) 2012-11-30
WO2010065803A1 (en) 2010-06-10
KR20110100639A (ko) 2011-09-14
EP2373652B1 (en) 2013-10-09
ES2441221T3 (es) 2014-02-03
KR101687216B1 (ko) 2016-12-16
PT2373652E (pt) 2014-01-16
CN102239168B (zh) 2014-03-12
IL213290A (en) 2014-01-30
US20120258979A1 (en) 2012-10-11
ECSP11011108A (es) 2011-11-30
CN102239168A (zh) 2011-11-09
CR20110294A (es) 2011-09-21
MA32943B1 (fr) 2012-01-02
DK2373652T3 (da) 2014-01-20
US20110257213A1 (en) 2011-10-20
CO6390058A2 (es) 2012-02-29
ZA201103448B (en) 2012-01-25
MX2011004939A (es) 2011-05-25
AU2009322248B2 (en) 2015-07-16
US8227481B2 (en) 2012-07-24
CA2745721A1 (en) 2010-06-10
RU2011127401A (ru) 2013-01-10
TN2011000233A1 (en) 2012-12-17
EP2373652A1 (en) 2011-10-12
US8604046B2 (en) 2013-12-10
JP2012511012A (ja) 2012-05-17
AU2009322248A1 (en) 2011-06-23
CA2745721C (en) 2013-09-24
TW201036974A (en) 2010-10-16

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