CO6390058A2 - Piperidina espiro pirrolidinona y piperidinona sustituidas usadas como moduladores de h3 - Google Patents
Piperidina espiro pirrolidinona y piperidinona sustituidas usadas como moduladores de h3Info
- Publication number
- CO6390058A2 CO6390058A2 CO11068488A CO11068488A CO6390058A2 CO 6390058 A2 CO6390058 A2 CO 6390058A2 CO 11068488 A CO11068488 A CO 11068488A CO 11068488 A CO11068488 A CO 11068488A CO 6390058 A2 CO6390058 A2 CO 6390058A2
- Authority
- CO
- Colombia
- Prior art keywords
- modulators
- pirrolidinona
- piperidinona
- espiro
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención describe y reivindica una serie de carboxamidas N-fenil-bipirrolidina sustituidas de fórmula (I).Donde R1, R2, R3, m, n y p son como se describen en el presente documento. Más específicamente, los compuestos de esta invención son moduladores de los receptores H3 y, por lo tanto, son útiles como agentes farmacéuticos, especialmente en el tratamiento y/o prevención de una variedad de enfermedades moduladas por los receptores H3, incluyendo enfermedades asociadas con el sistema nervioso central. Además, la presente invención también describe métodos para la preparación de carboxamidas N-fenil-bipirrolidina sustituidas e intermedios para ello.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12008808P | 2008-12-05 | 2008-12-05 | |
FR0955431 | 2009-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6390058A2 true CO6390058A2 (es) | 2012-02-29 |
Family
ID=41647030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO11068488A CO6390058A2 (es) | 2008-12-05 | 2011-06-02 | Piperidina espiro pirrolidinona y piperidinona sustituidas usadas como moduladores de h3 |
Country Status (24)
Country | Link |
---|---|
US (2) | US8227481B2 (es) |
EP (1) | EP2373652B1 (es) |
JP (1) | JP5538421B2 (es) |
KR (1) | KR101687216B1 (es) |
CN (1) | CN102239168B (es) |
AR (1) | AR074466A1 (es) |
AU (1) | AU2009322248B2 (es) |
CA (1) | CA2745721C (es) |
CO (1) | CO6390058A2 (es) |
CR (1) | CR20110294A (es) |
DK (1) | DK2373652T3 (es) |
EC (1) | ECSP11011108A (es) |
ES (1) | ES2441221T3 (es) |
IL (1) | IL213290A (es) |
MA (1) | MA32943B1 (es) |
MX (1) | MX2011004939A (es) |
NZ (1) | NZ593151A (es) |
PE (1) | PE20120261A1 (es) |
PT (1) | PT2373652E (es) |
RU (1) | RU2011127401A (es) |
TN (1) | TN2011000233A1 (es) |
TW (1) | TWI481609B (es) |
WO (1) | WO2010065803A1 (es) |
ZA (1) | ZA201103448B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
WO2011143155A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
JP2013526530A (ja) * | 2010-05-11 | 2013-06-24 | サノフイ | 置換されたn−フェニルスピロラクタムビピロリジン、その製造及び治療上の使用 |
AR081908A1 (es) | 2010-05-11 | 2012-10-31 | Sanofi Aventis | N-heteroaril-espirolactama-bipirrolidinas sustituidas, preparacion y usos terapeuticos de las mismas |
EP2569297A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
EP2569303A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-alkyl and n-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
EP2906542B1 (en) * | 2012-10-11 | 2019-08-07 | Merck Sharp & Dohme Corp. | Substituted spiropiperidinyl compounds useful as gpr120 agonists |
US9197285B2 (en) * | 2012-12-20 | 2015-11-24 | Deere & Company | Methods and apparatus for ameliorating signal reception |
EP3704121B1 (en) * | 2017-11-03 | 2022-12-21 | Bristol-Myers Squibb Company | Diazaspiro rock inhibitors |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3256276A (en) | 1961-02-17 | 1966-06-14 | Geschickter Fund Med Res | Substituted spiroimides |
FR2816940A1 (fr) | 2000-11-23 | 2002-05-24 | Lipha | Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation |
WO2004009558A2 (en) * | 2002-07-24 | 2004-01-29 | Ptc Therapeutics, Inc. | Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations |
EP1556046A1 (en) * | 2002-10-23 | 2005-07-27 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP4524550B2 (ja) | 2003-08-19 | 2010-08-18 | オイレス工業株式会社 | 摺動部材用樹脂組成物および摺動部材 |
CA2551037A1 (en) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
CN101151244B (zh) * | 2005-04-01 | 2014-09-03 | 伊莱利利公司 | 组胺h3受体活性剂、制备和治疗用途 |
BRPI0619446A2 (pt) | 2005-12-05 | 2011-10-04 | Incyte Corp | compostos de lactama, suas composições e método de modulação da atividade de 11bhsd1 |
DE602006014305D1 (de) * | 2005-12-16 | 2010-06-24 | Hoffmann La Roche | Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors |
NZ570503A (en) * | 2006-02-15 | 2010-07-30 | Sanofi Aventis | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
US20080247964A1 (en) | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
EP2049473A2 (en) | 2006-06-29 | 2009-04-22 | Janssen Pharmaceutica N.V. | Substituted benzyl amine compounds |
WO2008142859A1 (ja) * | 2007-05-18 | 2008-11-27 | Kowa Company, Ltd. | 新規なスピロオキシインドール化合物及びこれを含有する医薬 |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
US20100317679A1 (en) * | 2007-09-21 | 2010-12-16 | Ligand Pharmaceuticals, Inc. | Substituted aryl-fused spirocyclic amines |
RU2477721C2 (ru) * | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилпирролидинилметилпирролидинамиды и их терапевтическое применение в качестве модуляторов рецептора н3 гистамина |
AU2008312635B2 (en) | 2007-10-17 | 2013-05-16 | Sanofi | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
CN101903339B (zh) * | 2007-10-17 | 2012-06-27 | 赛诺菲-安万特 | 取代的n-苯基-联吡咯烷羧酰胺及其治疗用途 |
PE20110777A1 (es) | 2008-11-23 | 2011-10-29 | Pfizer | Nuevas lactamas como inhibidores de beta secretasa |
AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
-
2009
- 2009-12-03 AR ARP090104666A patent/AR074466A1/es not_active Application Discontinuation
- 2009-12-04 PE PE2011001148A patent/PE20120261A1/es not_active Application Discontinuation
- 2009-12-04 DK DK09793649.6T patent/DK2373652T3/da active
- 2009-12-04 MX MX2011004939A patent/MX2011004939A/es active IP Right Grant
- 2009-12-04 MA MA33987A patent/MA32943B1/fr unknown
- 2009-12-04 ES ES09793649.6T patent/ES2441221T3/es active Active
- 2009-12-04 PT PT97936496T patent/PT2373652E/pt unknown
- 2009-12-04 RU RU2011127401/04A patent/RU2011127401A/ru not_active Application Discontinuation
- 2009-12-04 CN CN200980148493.0A patent/CN102239168B/zh not_active Expired - Fee Related
- 2009-12-04 NZ NZ593151A patent/NZ593151A/xx not_active IP Right Cessation
- 2009-12-04 KR KR1020117015340A patent/KR101687216B1/ko active IP Right Grant
- 2009-12-04 JP JP2011539716A patent/JP5538421B2/ja not_active Expired - Fee Related
- 2009-12-04 AU AU2009322248A patent/AU2009322248B2/en not_active Ceased
- 2009-12-04 CA CA2745721A patent/CA2745721C/en not_active Expired - Fee Related
- 2009-12-04 EP EP09793649.6A patent/EP2373652B1/en active Active
- 2009-12-04 TW TW098141445A patent/TWI481609B/zh not_active IP Right Cessation
- 2009-12-04 WO PCT/US2009/066673 patent/WO2010065803A1/en active Application Filing
-
2011
- 2011-05-11 TN TN2011000233A patent/TN2011000233A1/fr unknown
- 2011-05-11 ZA ZA2011/03448A patent/ZA201103448B/en unknown
- 2011-05-31 IL IL213290A patent/IL213290A/en not_active IP Right Cessation
- 2011-06-01 CR CR20110294A patent/CR20110294A/es unknown
- 2011-06-02 US US13/151,946 patent/US8227481B2/en active Active
- 2011-06-02 CO CO11068488A patent/CO6390058A2/es not_active Application Discontinuation
- 2011-06-03 EC EC2011011108A patent/ECSP11011108A/es unknown
-
2012
- 2012-06-19 US US13/527,147 patent/US8604046B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6390058A2 (es) | Piperidina espiro pirrolidinona y piperidinona sustituidas usadas como moduladores de h3 | |
CO6390059A2 (es) | Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, su preparación y su uso terapéutico | |
CY1112083T1 (el) | Υποκαθιστουμενα ν-φαινυλο-διπυρρολιδινο καρβοξαμιδια και η θεραπευτικη τους χρηση | |
CY1112683T1 (el) | Υποκατεστημενες καρβοξαμιδες ν-φαινυλ-διπυρρολιδινης και θεραπευτικες χρησεις τους | |
GT201300174A (es) | Compuestos de indol o análogos de los mismos útiles para el tratamiento de la degeneración macular relacionada con la edad (dme) | |
CY1112391T1 (el) | Υποκατεστημενες ν-φαινυλ-διπυρρολιδινη ουριες και θεραπευτικες χρησεις αυτων | |
NI201100162A (es) | Derivados de indol como antagonistas del receptor crth2 | |
ECSP088210A (es) | Bencimidazoles sustituidos y métodos de preparación | |
CR9734A (es) | Derivados de 3-sulfonilindazol sustituido como ligandos de 5-hidroxitriptamina-6 | |
NI201100094A (es) | Piperidina espiro pirrolidinona y piperidinona sustituidas, su preparación y su uso terapéutico. | |
NI201100090A (es) | Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, su preparación y su uso terapéutico. | |
UY32294A (es) | Tetrahidropiran espiro pirrolidinona y piperidinona sustituidas, su preparación y su uso terapéutico | |
GT200600005A (es) | Un derivado de 2-(aminocarbonilo ciclico)-indolina y una composicion farmaceutica que lo contiene |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |