PE20091324A1 - Compuestos espiro como antagonistas del receptor npy y5 - Google Patents
Compuestos espiro como antagonistas del receptor npy y5Info
- Publication number
- PE20091324A1 PE20091324A1 PE2009000118A PE2009000118A PE20091324A1 PE 20091324 A1 PE20091324 A1 PE 20091324A1 PE 2009000118 A PE2009000118 A PE 2009000118A PE 2009000118 A PE2009000118 A PE 2009000118A PE 20091324 A1 PE20091324 A1 PE 20091324A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridinyl
- alkyl
- azaespiro
- decan
- ona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
REFERIDA A COMPUESTOS ESPIRO DE FORMULA (I) DONDE R ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO CON UNO O MAS HALO, ALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS; Z1 ES H, ALQUILO(C1-C4) O F; Z ES UN ENLACE, CH2, CH(ALQUILO C1-C4), ENTRE OTROS; A ES ARILO O HETEROARILO DE 5-6 MIEMBROS OPCIONALMENTES SUSTITUIDO CON HALO, ALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS; B ES H, FENILO, HETEROARILO DE 5-6 MIEMBROS, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: (TRANS)-3-FENIL-8-({[5-(TRIFLUOROMETIL)-2-PIRIDINIL]AMINO}METIL)-1-OXA-3-AZAESPIRO[4.5]DECAN-2-ONA, (TRANS)-3-(2-PIRIDINIL)-8-({[5-(TRIFLUOROMETIL)-2-PIRIDINIL]AMINO}METIL)-1-OXA-3-AZAESPIRO[4.5]DECAN-2-ONA, (TRANS)-3-(2-PIRIDINIL)-8-({[5-(2-PIRIMIDINIL)-2-PIRIDINIL]AMINO}METIL)-1-OXA-3-AZAESPIRO[4.5]DECAN-2-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR NPY Y5, SIENDO UTILES PARA EL TRATAMIENTO DE TRASTORNOS DE LA ALIMENTACION, TRASTORNOS DE LA BEBIDA, OBESIDAD O DEPRESION
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0801597A GB0801597D0 (en) | 2008-01-29 | 2008-01-29 | Chemical compounds |
GB0819112A GB0819112D0 (en) | 2008-10-17 | 2008-10-17 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091324A1 true PE20091324A1 (es) | 2009-09-25 |
Family
ID=40456386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000118A PE20091324A1 (es) | 2008-01-29 | 2009-01-28 | Compuestos espiro como antagonistas del receptor npy y5 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090203705A1 (es) |
AR (1) | AR070268A1 (es) |
CL (1) | CL2009000171A1 (es) |
PE (1) | PE20091324A1 (es) |
TW (1) | TW200944520A (es) |
UY (1) | UY31619A1 (es) |
WO (1) | WO2009095377A1 (es) |
Families Citing this family (44)
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WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
NZ566073A (en) * | 2005-09-21 | 2011-08-26 | 4Sc Ag | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors |
EA201001799A1 (ru) * | 2005-10-31 | 2011-06-30 | Янссен Фармацевтика Н.В. | Новые способы получения пиперазинильных и диазепанильных производных бензамида |
MX2008016008A (es) * | 2006-06-16 | 2009-01-16 | Lundbeck & Co As H | Formas cristalinas de 4-[2-(4-metilfenilsulfonil)-fenil] piperidina con inhibicion combinada de la recaptacion de serotonina y norepinefrina para el tratamiento del dolor neuropatico. |
CA2667345C (en) * | 2006-10-27 | 2016-03-22 | Signal Pharmaceuticals, Llc | Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol, compositions thereof, and uses therewith |
EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
AR071318A1 (es) * | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
CN102762551A (zh) | 2009-12-21 | 2012-10-31 | 拜尔农作物科学股份公司 | 噻吩基吡(嘧)啶基吡唑及其用于防治植物致病菌的用途 |
ES2742195T3 (es) | 2010-03-12 | 2020-02-13 | Omeros Corp | Inhibidores de PDE10 y composiciones y métodos relacionados |
CN103189360A (zh) * | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
JO3154B1 (ar) * | 2011-06-17 | 2017-09-20 | Glaxosmithkline Llc | عوامل مضادة لـ trpv4 |
WO2012174340A1 (en) * | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
EP2720546B1 (en) * | 2011-06-17 | 2016-04-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Spiro-cyclic trpv4 antagonists |
WO2013044816A1 (en) * | 2011-09-30 | 2013-04-04 | Sunshine Lake Pharma Co., Ltd. | Crystalline forms of azilsartan and preparation and uses thereof |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ630803A (en) * | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
BR112017021408B1 (pt) | 2015-04-08 | 2022-05-17 | Bayer Cropscience Aktiengesellschaft | Derivados de heterociclo bicíclico condensado, método para controlar pragas animais, e formulação agroquímica |
KR20170139074A (ko) | 2015-04-24 | 2017-12-18 | 오메로스 코포레이션 | Pde10 억제제 및 관련 조성물 및 방법 |
BR112018002571B1 (pt) | 2015-08-07 | 2022-04-05 | Bayer Cropscience Aktiengesellschaft | Derivados heterocíclicos condensados substituídos por 2-(het)arila como agentes de controle de praga, seu uso, formulação agroquímica, e método para controlar pragas animais |
BR112018008440B1 (pt) | 2015-10-26 | 2021-12-21 | Bayer Cropscience Aktiengesellschaft | Derivados de heterociclo bicíclico fusionado como pesticidas |
CA3003611C (en) | 2015-11-04 | 2022-11-01 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
WO2017093180A1 (de) | 2015-12-01 | 2017-06-08 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2017144341A1 (de) | 2016-02-23 | 2017-08-31 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2017174414A1 (de) | 2016-04-05 | 2017-10-12 | Bayer Cropscience Aktiengesellschaft | Naphthalin-derivate als schädlingsbekämpfungsmittel |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
BR112018073700A2 (pt) * | 2016-05-19 | 2019-02-26 | Glaxosmithkline Intellectual Property (No. | antagonista trpv4 |
BR112019001135B1 (pt) | 2016-07-19 | 2022-11-01 | Bayer Cropscience Aktiengesellschaft | Derivados de heterociclo bicíclico fundido como pesticidas, seu uso, formulação agroquímica, e método para controlar pragas animais |
PE20190800A1 (es) | 2016-08-15 | 2019-06-10 | Bayer Cropscience Ag | Derivados del heterociclo biciclico condensado como agentes de control de plagas |
CA3035195A1 (en) * | 2016-08-29 | 2018-03-08 | Michael J. Soth | Inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
EP3515921B1 (de) | 2016-09-19 | 2021-10-27 | Bayer CropScience Aktiengesellschaft | Pyrazolo[1,5-a]pyridin- derivative und ihre verwendung als schädlingsbekämpfungsmittel |
WO2018065288A1 (de) | 2016-10-07 | 2018-04-12 | Bayer Cropscience Aktiengesellschaft | 2-[2-phenyl-1-(sulfonylmethyl)vinyl]-imidazo[4,5-b]pyridin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel im pflanzenschutz |
EP3551610B1 (en) | 2016-12-08 | 2021-08-11 | Board of Regents, The University of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
CN110382485B (zh) | 2017-01-10 | 2022-05-10 | 拜耳公司 | 作为害虫防治剂的杂环烯衍生物 |
KR102628073B1 (ko) | 2017-01-10 | 2024-01-22 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 헤테로사이클 유도체 |
WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
ES2923376T3 (es) | 2017-04-24 | 2022-09-27 | Bayer Ag | Derivados de heterociclos bicíclicos fusionados como plaguicidas |
EP3305786A3 (de) | 2018-01-22 | 2018-07-25 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
JP2021514949A (ja) | 2018-02-21 | 2021-06-17 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としての縮合二環式ヘテロ環誘導体 |
BR112021010430A2 (pt) | 2019-02-26 | 2021-08-24 | Bayer Aktiengesellschaft | Derivados de heterociclo bicíclico fundido como pesticidas |
KR20210133984A (ko) | 2019-02-26 | 2021-11-08 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 축합된 비시클릭 헤테로시클릭 유도체 |
US11560366B2 (en) | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
CN111303230B (zh) * | 2020-03-09 | 2021-07-13 | 中国食品药品检定研究院 | 一种黄体酮共晶物及其制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005030051A1 (de) * | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
JP2010502705A (ja) * | 2006-09-07 | 2010-01-28 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病の治療用としてのスピロピペリジンベータセクレターゼ阻害剤 |
JP2010517966A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | 摂食障害の処置のための1−オキサ−3−アザスピロ(4.5)デカン−2−オンおよび1−オキサ−3,8−ジアザスピロ(4.5)デカン−2−オン誘導体 |
WO2008092891A1 (en) * | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | 1-oxa-3-azaspiro(4.5)decan-2-one derivatives for the treatment of eating disorders |
GB0707934D0 (en) * | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
WO2009112033A1 (en) * | 2008-03-12 | 2009-09-17 | Københavns Universitet (University Of Copenhagen) | Use of npy y5 receptor antagonists for the prevention of psychostimulant and opioid abuse |
-
2009
- 2009-01-23 TW TW098102965A patent/TW200944520A/zh unknown
- 2009-01-27 AR ARP090100249A patent/AR070268A1/es unknown
- 2009-01-27 WO PCT/EP2009/050867 patent/WO2009095377A1/en active Application Filing
- 2009-01-27 CL CL2009000171A patent/CL2009000171A1/es unknown
- 2009-01-27 US US12/360,166 patent/US20090203705A1/en not_active Abandoned
- 2009-01-28 PE PE2009000118A patent/PE20091324A1/es not_active Application Discontinuation
- 2009-01-29 UY UY031619A patent/UY31619A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CL2009000171A1 (es) | 2009-11-27 |
UY31619A1 (es) | 2009-08-31 |
TW200944520A (en) | 2009-11-01 |
US20090203705A1 (en) | 2009-08-13 |
WO2009095377A1 (en) | 2009-08-06 |
AR070268A1 (es) | 2010-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |