AR070268A1 - Compuesto de oxa-azaspiro, su uso para la fabricacion de un medicamento para la modulacion de receptores y5 de npy y composicion farmaceutica que lo comprende - Google Patents
Compuesto de oxa-azaspiro, su uso para la fabricacion de un medicamento para la modulacion de receptores y5 de npy y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR070268A1 AR070268A1 ARP090100249A ARP090100249A AR070268A1 AR 070268 A1 AR070268 A1 AR 070268A1 AR P090100249 A ARP090100249 A AR P090100249A AR P090100249 A ARP090100249 A AR P090100249A AR 070268 A1 AR070268 A1 AR 070268A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- haloalkoxy
- haloalkyl
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Compuestos utiles para el tratamiento y/o profilaxis de trastornos de la alimentacion, tales como la obesidad. Reivindicacion 1: Un compuesto de oxa-azaspiro caracterizado porque es de la formula (1) o una sal farmacéuticamente aceptable del mismo, en la que R es un arilo o heteroarilo, que puede estar sustituido con uno o más halogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4 o ciano; Z1 es H, alquilo C1-4 o F; Z es CH2, CH(alquilo C1-4), C(alquilo C1-4)2 o un enlace; A es un arilo o heteroarilo de 6-10 miembros, que puede estar sustituido con uno o más halogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4 o ciano; o C(=O)-X; o -O(CH2)0-1R1; B es hidrogeno o es un heteroarilo de 5-6 miembros, o un heterociclo de 4-6 miembros, o fenilo, que puede estar sustituido con uno o más halogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, hidroxilo, ciano; donde A y B están unidos mediante cualquier átomo; R1 es -alquil C1-4-alcoxi C1-4; o cicloalquilo C3-8; o R1 es un arilo o heteroarilo, que puede estar sustituido con uno o más halogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4 o ciano; o R1 es un heterociclo de 4-6 miembros, que puede estar sustituido con uno o más halogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4 o ciano; X es OR2 o NR3R4; R2 es alquilo C1-4; R3 es hidrogeno o junto con R4 y el átomo de nitrogeno forma un anillo saturado de 5-6 miembros; R4 es cicloalquilo C3-8.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0801597A GB0801597D0 (en) | 2008-01-29 | 2008-01-29 | Chemical compounds |
| GB0819112A GB0819112D0 (en) | 2008-10-17 | 2008-10-17 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070268A1 true AR070268A1 (es) | 2010-03-25 |
Family
ID=40456386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100249A AR070268A1 (es) | 2008-01-29 | 2009-01-27 | Compuesto de oxa-azaspiro, su uso para la fabricacion de un medicamento para la modulacion de receptores y5 de npy y composicion farmaceutica que lo comprende |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090203705A1 (es) |
| AR (1) | AR070268A1 (es) |
| CL (1) | CL2009000171A1 (es) |
| PE (1) | PE20091324A1 (es) |
| TW (1) | TW200944520A (es) |
| UY (1) | UY31619A1 (es) |
| WO (1) | WO2009095377A1 (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1776365B1 (en) * | 2004-06-02 | 2011-08-03 | Sandoz Ag | Meropenem intermediate in crystalline form |
| EA018698B1 (ru) * | 2005-09-21 | 2013-10-30 | 4Сц Аг | Сульфонилпирролгидрохлориды как ингибиторы гистондезацетилазы |
| NZ567357A (en) * | 2005-10-31 | 2011-05-27 | Janssen Pharmaceutica Nv | Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives |
| MX2008016008A (es) * | 2006-06-16 | 2009-01-16 | Lundbeck & Co As H | Formas cristalinas de 4-[2-(4-metilfenilsulfonil)-fenil] piperidina con inhibicion combinada de la recaptacion de serotonina y norepinefrina para el tratamiento del dolor neuropatico. |
| EP2615091B1 (en) * | 2006-10-27 | 2016-01-20 | Signal Pharmaceuticals, LLC | Solid forms comprising 4-[9-(3S)-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9H-purin-2-ylamino]-trans-cyclohexan-1-ol, compositions thereof, and uses therewith |
| EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
| US7935817B2 (en) * | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
| AR071318A1 (es) * | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
| US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
| AR079545A1 (es) | 2009-12-21 | 2012-02-01 | Bayer Cropscience Ag | Tienilpiri(mi)dinilazol |
| ES2742195T3 (es) | 2010-03-12 | 2020-02-13 | Omeros Corp | Inhibidores de PDE10 y composiciones y métodos relacionados |
| CA2808904A1 (en) * | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-ht2c agonists |
| EP2720546B1 (en) * | 2011-06-17 | 2016-04-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Spiro-cyclic trpv4 antagonists |
| WO2012174340A1 (en) * | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
| JO3154B1 (ar) * | 2011-06-17 | 2017-09-20 | Glaxosmithkline Llc | عوامل مضادة لـ trpv4 |
| US9174973B2 (en) * | 2011-09-30 | 2015-11-03 | Sunshine Lake Pharma Co., Ltd. | Crystalline forms of azilsartan and preparation and uses thereof |
| NZ630810A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| NZ630803A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
| ES2779532T3 (es) | 2015-04-08 | 2020-08-18 | Bayer Cropscience Ag | Derivados de imidazo[1,2a]piridin-2-ilo como pesticidas y sus productos intermedios |
| CN107530313A (zh) | 2015-04-24 | 2018-01-02 | 奥默罗斯公司 | Pde10抑制剂以及相关组合物和方法 |
| PE20180783A1 (es) | 2015-08-07 | 2018-05-07 | Bayer Cropscience Ag | Derivados heterociclicos condensados sustituidos por 2-(het) arilo como pesticidas |
| RU2018119344A (ru) | 2015-10-26 | 2019-11-28 | Байер Кропсайенс Акциенгезельшафт | Конденсированные бициклические гетероциклические производные в качестве средства для борьбы с вредителями |
| CA3003611C (en) | 2015-11-04 | 2022-11-01 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
| WO2017093180A1 (de) | 2015-12-01 | 2017-06-08 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| WO2017144341A1 (de) | 2016-02-23 | 2017-08-31 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| WO2017174414A1 (de) | 2016-04-05 | 2017-10-12 | Bayer Cropscience Aktiengesellschaft | Naphthalin-derivate als schädlingsbekämpfungsmittel |
| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| EP3458451B1 (en) * | 2016-05-19 | 2020-06-03 | Glaxosmithkline Intellectual Property (No. 2) Limited | Trpv4 antagonist |
| AU2017298972B2 (en) | 2016-07-19 | 2021-03-04 | Bayer Cropscience Aktiengesellschaft | Condensed bicyclic heterocycle derivatives as pest control agents |
| JP6997420B2 (ja) | 2016-08-15 | 2022-01-17 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 有害生物防除剤としての縮合二環式ヘテロ環誘導体 |
| CN109789132A (zh) * | 2016-08-29 | 2019-05-21 | 德州大学系统董事会 | 用于治疗疾病的双亮氨酸拉链(dlk)激酶抑制剂 |
| US10611779B2 (en) | 2016-09-19 | 2020-04-07 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
| WO2018065288A1 (de) | 2016-10-07 | 2018-04-12 | Bayer Cropscience Aktiengesellschaft | 2-[2-phenyl-1-(sulfonylmethyl)vinyl]-imidazo[4,5-b]pyridin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel im pflanzenschutz |
| BR112019011801A2 (pt) | 2016-12-08 | 2019-10-29 | Univ Texas | composto, composição farmacêutica e método de inibição de dlk, método de tratamento de uma doença mediada por dlk, método de tratamento de câncer e redução do desenvolvimento de um distúrbio neurológico induzido por quimioterapia e método para alcançar um efeito em um paciente |
| AU2018208422B2 (en) | 2017-01-10 | 2021-11-11 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| WO2018130437A1 (de) | 2017-01-10 | 2018-07-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
| WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| CN110582503B (zh) | 2017-04-24 | 2022-05-31 | 拜耳公司 | 作为有害物防治剂的稠合双环杂环化合物衍生物 |
| EP3305786A3 (de) | 2018-01-22 | 2018-07-25 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| CN111741958A (zh) | 2018-02-21 | 2020-10-02 | 拜耳公司 | 作为害虫防治剂的稠合双环杂环衍生物 |
| WO2020173860A1 (en) | 2019-02-26 | 2020-09-03 | Bayer Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
| JP2022521439A (ja) | 2019-02-26 | 2022-04-07 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としての縮合二環式複素環式誘導体 |
| US11485727B2 (en) * | 2019-07-22 | 2022-11-01 | Boehringer Ingelheim International Gmbh | N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators |
| US11560366B2 (en) | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| CN111303230B (zh) * | 2020-03-09 | 2021-07-13 | 中国食品药品检定研究院 | 一种黄体酮共晶物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005030051A1 (de) * | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| AU2007293416A1 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| TW200900060A (en) * | 2007-02-01 | 2009-01-01 | Glaxo Group Ltd | Chemical compounds |
| US20100197699A1 (en) * | 2007-02-01 | 2010-08-05 | Glaxo Group Limited | I-OXA-3-Azaspiro (4.5) Decan-2-One And 1-OXA-3, 8-Diazaspiro (4.5) Decan-2-One Derivatives For The Treatment of Eating Disorders |
| GB0707934D0 (en) * | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
| EP2280703A1 (en) * | 2008-03-12 | 2011-02-09 | Københavns Universitet (University Of Copenhagen) | Use of npy y5 receptor antagonists for the prevention of psychostimulant and opioid abuse |
-
2009
- 2009-01-23 TW TW098102965A patent/TW200944520A/zh unknown
- 2009-01-27 WO PCT/EP2009/050867 patent/WO2009095377A1/en active Application Filing
- 2009-01-27 AR ARP090100249A patent/AR070268A1/es unknown
- 2009-01-27 CL CL2009000171A patent/CL2009000171A1/es unknown
- 2009-01-27 US US12/360,166 patent/US20090203705A1/en not_active Abandoned
- 2009-01-28 PE PE2009000118A patent/PE20091324A1/es not_active Application Discontinuation
- 2009-01-29 UY UY031619A patent/UY31619A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20091324A1 (es) | 2009-09-25 |
| WO2009095377A1 (en) | 2009-08-06 |
| US20090203705A1 (en) | 2009-08-13 |
| CL2009000171A1 (es) | 2009-11-27 |
| UY31619A1 (es) | 2009-08-31 |
| TW200944520A (en) | 2009-11-01 |
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