UY32622A - Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) - Google Patents

Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Info

Publication number
UY32622A
UY32622A UY0001032622A UY32622A UY32622A UY 32622 A UY32622 A UY 32622A UY 0001032622 A UY0001032622 A UY 0001032622A UY 32622 A UY32622 A UY 32622A UY 32622 A UY32622 A UY 32622A
Authority
UY
Uruguay
Prior art keywords
beta
treatment
new compounds
pathologies related
relates
Prior art date
Application number
UY0001032622A
Other languages
English (en)
Inventor
Lo-Alfredsson Yvonne
Rakos Laszlo
Paulsen Kim
Waldman Magnus
Rotticci Didier
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY32622A publication Critical patent/UY32622A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención se refiere a novedosos compuestos de fórmula I y II y sales terapéuticamente aceptables de los mismos, sus composiciones farmacéuticas, procesos para prepararlos y su uso en métodos terapéuticos para el tratamiento y/o la prevención de distintas enfermedades. En particular, la invención se refiere a compuestos que interfieren con la y-secretasa y/o su sustrato y, por consiguiente, modulan la formación de péptidos AB(beta).
UY0001032622A 2009-05-12 2010-05-10 Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) UY32622A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17730509P 2009-05-12 2009-05-12
US28960009P 2009-12-23 2009-12-23

Publications (1)

Publication Number Publication Date
UY32622A true UY32622A (es) 2010-12-31

Family

ID=43069012

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032622A UY32622A (es) 2009-05-12 2010-05-10 Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Country Status (5)

Country Link
US (1) US20100292210A1 (es)
AR (1) AR076760A1 (es)
TW (1) TW201043635A (es)
UY (1) UY32622A (es)
WO (1) WO2010132015A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102272133A (zh) 2008-11-06 2011-12-07 阿斯利康(瑞典)有限公司 淀粉样β的调节剂
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
US20120122843A1 (en) * 2010-11-11 2012-05-17 Astrazeneca Ab Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases
US9006226B2 (en) 2012-02-23 2015-04-14 Boehringer Ingelheim International Gmbh Dihydropteridinones I
US8865716B2 (en) 2012-02-23 2014-10-21 Boehringer Ingelheim International Gmbh Dihydropteridinones II
JP6072308B2 (ja) 2013-02-21 2017-02-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノンｉｉ
EP2958919B1 (en) 2013-02-21 2019-05-22 Boehringer Ingelheim International GmbH Dihydropteridinones i
US9611254B2 (en) 2013-06-04 2017-04-04 Acturum Life Science AB Triazole compounds and their use as gamma secretase modulators
CN105263922B (zh) 2013-06-04 2018-08-17 阿克图拉姆生命科学股份公司 三唑化合物及其作为γ分泌酶调节剂的用途
JP6368777B2 (ja) * 2013-06-04 2018-08-01 アクチュラム・ライフ・サイエンス・アクチエボラーグ ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用
WO2017026538A1 (en) 2015-08-07 2017-02-16 Takeda Pharmaceutical Company Limited Production method of pyrazine
CA3023379A1 (en) * 2016-05-06 2017-11-09 Esteve Pharmaceuticals, S.A. Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions
WO2018124001A1 (ja) 2016-12-27 2018-07-05 国立研究開発法人理化学研究所 Ｂｍｐシグナル阻害化合物
CN117720541A (zh) 2018-03-09 2024-03-19 里科瑞尔姆Ip控股有限责任公司 取代的1,2-二氢-3H-吡唑并[3,4-d]嘧啶-3-酮
KR20230066328A (ko) * 2020-09-09 2023-05-15 (주)스파크바이오파마 신규 피리미도디아제핀 유도체 및 이의 용도
EP4329766A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Ripk1 inhibitors and methods of use
EP4329765A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Phenyl azepines as ripk1 inhibitors and methods of use thereof
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100549014C (zh) * 2003-07-16 2009-10-14 詹森药业有限公司 作为糖原合酶激酶3抑制剂的三唑并嘧啶衍生物
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
US7880009B2 (en) * 2004-05-26 2011-02-01 Eisai R&D Management Co., Ltd. Cinnamide compound
CN101448793A (zh) * 2006-05-19 2009-06-03 卫材R&D管理有限公司 脲型肉桂酰胺衍生物
AU2007252644A1 (en) * 2006-05-19 2007-11-29 Eisai R & D Management Co., Ltd. Heterocyclic type cinnamide derivative
US20090099195A1 (en) * 2007-05-08 2009-04-16 Astrazeneca Ab Therapeutic Compounds 570
AU2008250436B2 (en) * 2007-05-11 2013-03-28 F. Hoffmann-La Roche Ag Hetarylanilines as modulators for amyloid beta
US20110009392A1 (en) * 2007-08-06 2011-01-13 Schering Corporation Gamma secretase modulators
CN102272133A (zh) * 2008-11-06 2011-12-07 阿斯利康(瑞典)有限公司 淀粉样β的调节剂

Also Published As

Publication number Publication date
AR076760A1 (es) 2011-07-06
TW201043635A (en) 2010-12-16
WO2010132015A1 (en) 2010-11-18
US20100292210A1 (en) 2010-11-18

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Legal Events

Date Code Title Description
DESI Application deemed to be withdrawn

Effective date: 20130123