PE20081791A1 - Dos derivados ciclicos de oxomorfolina - Google Patents

Dos derivados ciclicos de oxomorfolina

Info

Publication number
PE20081791A1
PE20081791A1 PE2008000381A PE2008000381A PE20081791A1 PE 20081791 A1 PE20081791 A1 PE 20081791A1 PE 2008000381 A PE2008000381 A PE 2008000381A PE 2008000381 A PE2008000381 A PE 2008000381A PE 20081791 A1 PE20081791 A1 PE 20081791A1
Authority
PE
Peru
Prior art keywords
oxazin
oxomorpholin
trifluorophenyl
ona
tetrahydro
Prior art date
Application number
PE2008000381A
Other languages
English (en)
Inventor
Teiji Kimura
Noritaka Kitazawa
Toshihiko Kaneko
Takehiko Miyagawa
Koki Kawano
Mamoru Takaishi
Takeo Sasaki
Eriko Doi
Koichi Ito
Nobuaki Sato
Original Assignee
Eisai Randd Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39716667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081791(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai Randd Man Co Ltd filed Critical Eisai Randd Man Co Ltd
Publication of PE20081791A1 publication Critical patent/PE20081791A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE OXOMORFOLINA DE FORMULA I, DONDE R1 ES ALQUILO C1-C3; R2 ES H, ALQUILO C1-C3 O R1 Y R2 JUNTO AL CARBONO AL QUE ESTAN UNIDO SON CICLOALQUILO C3-C6; Ar ES FENILO SUSTITUIDO O NO; X ES METILENO SUSTITUIDO O NO; m Y n SON 0-2. SON SELECCIONADOS: (Z)(1R, 6R, 9aR)-3-[3-METOXI-4-(4-METILIMIDAZOL-1-IL)BENCILIDEN]-1-METIL-6-(3,4,5-TRIFLUOROFENIL)TETRAHIDRO-[1,4]OXAZIN[3,4-c][1,4]-OXAZIN-4-ONA; (6R,9aR)-3-[1-[3-METOXI-4-(4-METIL-1H-IMIDAZOL-2-IL)FENIL-(Z)-METILIDEN]-1,1-DIMETIL-6-(3,4,5-TRIFLUOROFENIL)TETRAHIDRO[1,4[OXAZIN[3,4-c][1,4]OXAZIN-4-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON DE UTILIDAD EN EL TRATAMIENTO DE ENFERMEDADES ATRIBUIBLES A AMILOIDE BETA, TALES COMO ALZHEIMER, DEMENCIA SENIL, SINDROME DE DOWN O AMILOIDOSIS
PE2008000381A 2007-02-28 2008-02-26 Dos derivados ciclicos de oxomorfolina PE20081791A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89199707P 2007-02-28 2007-02-28
JP2007049085 2007-02-28

Publications (1)

Publication Number Publication Date
PE20081791A1 true PE20081791A1 (es) 2009-02-07

Family

ID=39716667

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000381A PE20081791A1 (es) 2007-02-28 2008-02-26 Dos derivados ciclicos de oxomorfolina

Country Status (11)

Country Link
US (2) US20080207900A1 (es)
EP (1) EP2125829B1 (es)
JP (1) JP5244096B2 (es)
KR (1) KR20090116704A (es)
CN (1) CN101622258B (es)
AU (1) AU2008221906C1 (es)
CA (1) CA2678100A1 (es)
CL (1) CL2008000582A1 (es)
PE (1) PE20081791A1 (es)
TW (1) TW200848054A (es)
WO (1) WO2008108378A2 (es)

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WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
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EP2401277A1 (en) 2009-02-26 2012-01-04 Eisai R&D Management Co., Ltd. Salt of tetrahydrotriazolopyridine derivative and crystal thereof
CA2753696A1 (en) 2009-02-26 2010-09-02 Noritaka Kitazawa Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
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TW201113269A (en) * 2009-06-24 2011-04-16 Boehringer Ingelheim Int New compounds, pharmaceutical composition and methods relating thereto
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JP5584352B2 (ja) 2010-03-15 2014-09-03 アムジエン・インコーポレーテツド β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途
EP2601197B1 (en) 2010-08-05 2014-06-25 Amgen Inc. Amino-iso-indole, amino-aza-iso-indole, amino-dihydroisoquinoline and amino-benzoxazine compounds as beta-secretase modulators and methods of use
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US9346827B2 (en) 2011-02-07 2016-05-24 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
WO2012112462A1 (en) 2011-02-15 2012-08-23 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
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WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
US9725469B2 (en) 2012-11-15 2017-08-08 Amgen, Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
EP3253755B1 (en) 2015-02-03 2020-08-26 Pfizer Inc Novel cyclopropabenzofuranyl pyridopyrazinediones
WO2019098256A1 (ja) * 2017-11-16 2019-05-23 株式会社幹細胞＆デバイス研究所 デバイス

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Also Published As

Publication number Publication date
AU2008221906A1 (en) 2008-09-12
JP5244096B2 (ja) 2013-07-24
TW200848054A (en) 2008-12-16
WO2008108378A3 (en) 2008-12-04
CN101622258B (zh) 2012-06-13
AU2008221906C1 (en) 2012-12-13
EP2125829A2 (en) 2009-12-02
KR20090116704A (ko) 2009-11-11
CL2008000582A1 (es) 2008-06-27
AU2008221906B2 (en) 2012-04-12
CN101622258A (zh) 2010-01-06
WO2008108378A2 (en) 2008-09-12
EP2125829B1 (en) 2013-01-16
JP2010520152A (ja) 2010-06-10
US8008293B2 (en) 2011-08-30
US20080207900A1 (en) 2008-08-28
CA2678100A1 (en) 2008-09-12
US20100113773A1 (en) 2010-05-06

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