AR012924A1 - Derivados de tiazolidindiona, oxazolidindiona y oxadiazolidindiona, proceso para su preparacion, composiciones y formulaciones farmaceuticas, usode dichos compuestos para la fabricacion de formulaciones y metodo de tratamiento - Google Patents
Derivados de tiazolidindiona, oxazolidindiona y oxadiazolidindiona, proceso para su preparacion, composiciones y formulaciones farmaceuticas, usode dichos compuestos para la fabricacion de formulaciones y metodo de tratamientoInfo
- Publication number
- AR012924A1 AR012924A1 ARP980102644A ARP980102644A AR012924A1 AR 012924 A1 AR012924 A1 AR 012924A1 AR P980102644 A ARP980102644 A AR P980102644A AR P980102644 A ARP980102644 A AR P980102644A AR 012924 A1 AR012924 A1 AR 012924A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- substituted
- alkylaryl
- formulations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados de tiazolidindiona, oxazolidindiona, y oxadiazolidindiona que tienen formula general I, e isomeros estereo y opticos y racematos del mismo,así como también sales solvatos e hidratos del mismo farmacéuticamente aceptables, en donde la línea punteada es un enlace simple o doble, R es H oalquilo, A es S, O o NH, B es C, CH o N, D está situado en la posicion orto, meta o para , y representa CN o -X-Y-Z, D está situado en la posicion orto,meta o para, y representa H, -O-alquilo,alquilo, halogeno o -X-Y-Z, en donde X es O, NR1, SO2 o S, R1 es H o alquilo, Y es SO2, CO, o un enlace químico, Z esalquilo, alquilo sustituido con uno o más átomos de fluoro o cloro, arilo, arilo sustituido, alquilarilo, OR2 o NHR3, en donde R2 es alquilo, arilo,alquilarilo, arilo sustituido o alquilo sustituido, R3 es H, alquilo, arilo alquilarilo, arilo sustituido o alquilo sustituido, siempre que cuando X es O oNR1, entonces Y es ya sea SO2 o CO, y Z es, cuando Y es a) SO2, seleccionado del grupo que consiste de alquilo, alquilo sustituido con uno o más átomos defluoro o cloro, arilo, arilo sustituido y alquilarilo, cuando Y es b) CO, seleccionado del grupo que consiste de OR2 y NHR3 en donde R2 y R3 son como sedefinen anteriormente, cuando X es SO2 entonces Y es un enlace químico y Z es seleccionado del grupo que consiste de alquilo, alquilo sustituido con uno omás átomos de fluoro o cloro, arilo sustituido, alquilarilo y OR2, en donde R2 es como se define con anterioridad, cuando X es S, entonces Y es un enlacequímico y Z es seleccionado del grupo que consiste de alquilo, alquilo sustituido con uno o más átomos de fluoro o cloro, arilo, arilo sustituido yalquilarilo, y además siempre que cuando B es N, A es O; proceso para su preparacion, composiciones y formulaciones farmacéuticas que los contienen
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702305A SE9702305D0 (sv) | 1997-06-17 | 1997-06-17 | New thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012924A1 true AR012924A1 (es) | 2000-11-22 |
Family
ID=20407407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102644A AR012924A1 (es) | 1997-06-17 | 1998-06-04 | Derivados de tiazolidindiona, oxazolidindiona y oxadiazolidindiona, proceso para su preparacion, composiciones y formulaciones farmaceuticas, usode dichos compuestos para la fabricacion de formulaciones y metodo de tratamiento |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6288096B1 (es) |
| EP (1) | EP0991632A1 (es) |
| JP (1) | JP2002503255A (es) |
| AR (1) | AR012924A1 (es) |
| AU (1) | AU732105B2 (es) |
| CA (1) | CA2293449A1 (es) |
| NZ (1) | NZ501428A (es) |
| SE (1) | SE9702305D0 (es) |
| WO (1) | WO1998057941A1 (es) |
| ZA (1) | ZA984795B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
| US7230016B2 (en) * | 2003-05-13 | 2007-06-12 | Synthon Ip Inc. | Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same |
| EP1622898A1 (en) * | 2003-05-13 | 2006-02-08 | Synthon B.V. | Processes for making thiazolidinedione derivatives and compounds thereof |
| WO2005080387A2 (en) * | 2004-02-20 | 2005-09-01 | Synthon B.V. | Processes for making pioglitazone and compounds of the processes |
| US7161756B2 (en) * | 2004-05-10 | 2007-01-09 | Tandberg Data Storage Asa | Method and system for communication between a tape drive and an external device |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| WO2006138328A1 (en) * | 2005-06-14 | 2006-12-28 | Merck & Co., Inc. | Process for the production of antidiabetic oxazolidinediones |
| TW200815377A (en) * | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| EP3788877A1 (en) | 2007-04-11 | 2021-03-10 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| WO2011133442A1 (en) | 2010-04-19 | 2011-10-27 | Metabolic Solutions Development Company | Novel synthesis for thiazolidinedione compounds |
| CA2796872A1 (en) * | 2010-04-19 | 2011-10-27 | Metabolic Solutions Development Company, Llc | Novel synthesis for thiazolidinedione compounds |
| JP5851506B2 (ja) | 2010-08-10 | 2016-02-03 | メタボリック ソリューションズ ディベロップメント カンパニー， エルエルシー | チアゾリジンジオン化合物のための合成 |
| ES2609837T3 (es) | 2010-08-10 | 2017-04-24 | Octeta Therapeutics, Llc | Nueva síntesis de compuestos de tiazolidindiona |
| HUE030062T2 (en) | 2010-11-08 | 2017-04-28 | Albireo Ab | IBAT inhibitors for the treatment of liver diseases |
| PT2637646T (pt) | 2010-11-08 | 2016-08-17 | Albireo Ab | Uma combinação farmacêutica que compreende um inibidor do ibat e um sequestrador de ácido biliar |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| US5223522A (en) | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
-
1997
- 1997-06-17 SE SE9702305A patent/SE9702305D0/xx unknown
-
1998
- 1998-06-03 ZA ZA984795A patent/ZA984795B/xx unknown
- 1998-06-04 CA CA002293449A patent/CA2293449A1/en not_active Abandoned
- 1998-06-04 EP EP98928757A patent/EP0991632A1/en not_active Withdrawn
- 1998-06-04 WO PCT/SE1998/001066 patent/WO1998057941A1/en not_active Application Discontinuation
- 1998-06-04 AR ARP980102644A patent/AR012924A1/es unknown
- 1998-06-04 US US09/091,875 patent/US6288096B1/en not_active Expired - Fee Related
- 1998-06-04 AU AU80475/98A patent/AU732105B2/en not_active Ceased
- 1998-06-04 JP JP50425699A patent/JP2002503255A/ja active Pending
- 1998-06-04 NZ NZ501428A patent/NZ501428A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0991632A1 (en) | 2000-04-12 |
| JP2002503255A (ja) | 2002-01-29 |
| WO1998057941A1 (en) | 1998-12-23 |
| AU732105B2 (en) | 2001-04-12 |
| CA2293449A1 (en) | 1998-12-23 |
| NZ501428A (en) | 2001-05-25 |
| US6288096B1 (en) | 2001-09-11 |
| ZA984795B (en) | 1999-01-04 |
| AU8047598A (en) | 1999-01-04 |
| SE9702305D0 (sv) | 1997-06-17 |
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