BR9810924A - Composto heterocìclico espiroazabicìclico, composição farmacêutica, uso de um composto, e, processos de tratamento ou profilaxia de doenças humanas ou condições em que a ativação do receptor nicotìnico alfa7 seja benéfica, de distúrbios psicóticos ou distúrbios do enfraquecimento intelectual e do desequilìbrio do ritmo circadiano normal devido a viagens subsÈnicas ou supersÈnicas, da cessação de fumar, do vìcio da nicotina, da dor e da colite ulcerativa e de preparação de um composto - Google Patents
Composto heterocìclico espiroazabicìclico, composição farmacêutica, uso de um composto, e, processos de tratamento ou profilaxia de doenças humanas ou condições em que a ativação do receptor nicotìnico alfa7 seja benéfica, de distúrbios psicóticos ou distúrbios do enfraquecimento intelectual e do desequilìbrio do ritmo circadiano normal devido a viagens subsÈnicas ou supersÈnicas, da cessação de fumar, do vìcio da nicotina, da dor e da colite ulcerativa e de preparação de um compostoInfo
- Publication number
- BR9810924A BR9810924A BR9810924-3A BR9810924A BR9810924A BR 9810924 A BR9810924 A BR 9810924A BR 9810924 A BR9810924 A BR 9810924A BR 9810924 A BR9810924 A BR 9810924A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- alkyl
- disorders
- prophylaxis
- pain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"COMPOSTO HETEROCìCLICO ESPIROAZABICìCLICO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSOS DE TRATAMENTO OU PROFILAXIA DE DOENçAS HUMANAS OU CONDIçõES EM QUE A ATIVAçãO DO RECEPTOR NICOTìNICO ALFA7 SEJA BENéFICA, DE DISTúRBIOS PSICóTICOS OU DISTúRBIOS DO ENFRAQUECIMENTO INTELECTUAL E DO DESEQUILìBRIO DO RITMO CIRCADIANO NORMAL DEVIDO A VIAGENS SUBSÈNICAS OU SUPERSÈNICAS, DA CESSAçãO DE FUMAR, DO VìCIO DA NICOTINA, DA DOR E DA COLITE ULCERATIVA E DE PREPARAçãO DE UM COMPOSTO". Um composto de fórmula (I) em que n é 0 ou 1; m é 0 ou 1; p é 0 ou 1; X é oxigênio ou enxofre; Y é CH, N ou NO; W é oxigênio, H~ 2~ ou F~ 2~; A é N ou C(R²); G é N ou C(R³); D é N ou C(R^ 4^); com a condição de que não mais do que um dentre A, G e D seja nitrogênio, mas pelo menos um dentre Y, A, G e D seja nitrogênio ou NO; R. é hidrogênio ou alquila C~ 1~ a C~ 4~; R², R³ e R^ 4^ são independentemente hidrogênio, halógeno, alquila C~ 1~-C~ 4~, alquenila C~ 2~-C~ 4~, alquila C~ 2~-C~ 4~, arila, heteroarila, OH, alquila OC~ 1~-C~ 4~, CO~ 2~R~ 1~, -CN, -NO~ 2~, -NR^ 5^R^ 6^, -CF~ 3~, -OSO~ 2~CF~ 3~ ou R² e R³, ou R³ e R^ 4^, respectivamente, podem, juntos, formar outro anel aromático ou heteroaromático de seis membros compartilhado A e G, ou G e D, respectivamente, contendo entre zero e dois átomos de nitrogênio, e substituído por um a dois dos seguintes substituintes; independentemente hidrogênio, halógeno, alquila C~ 1~-C~ 4~, alquelina C~ 2~-C~ 4~, alquinila C~ 2~-C~ 4~, arila, heteroarila, OH, alquila OC~ 1~-C~ 4~, CO~ 2~R~ 1~, -CN, -NO~ 2~, -NR^ 5^R^ 6^, -CF~ 3~, -OSO~ 2~CF~ 3~; R^ 5^ e R^ 6^ são independentemente hidrogênio, alquila C~ 1~-C~ 4~, C(O)R^ 7^, C(O)NHR^ 8^, C(O)OR^ 9^, SO~ 2~R^ 10^, ou podem, juntos, ser (CH~ 2~)~ j~Q(CH~ 2~)~ k~, onde Q é O, S, NR^ 11^ ou uma ligação; j é de 2 a 7, k é de 0 a 2; R^ 7^, R^ 8^, R^ 9^, R^ 10^ e R^ 11^ são independentemente alquila C~ 1~-C~ 4~, arila ou heteroarila, ou um seu enantiómero, e os seus sais farmaceuticamente aceitáveis, processos para prepará-los, composição contendo-os, e seu uso em terapia, especialmente no tratamento ou profilaxia da distúrbios psicóticos e distúrbios de enfraquecimento intelectual.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702746A SE9702746D0 (sv) | 1997-07-18 | 1997-07-18 | New compounds |
| SE9800977A SE9800977D0 (sv) | 1998-03-24 | 1998-03-24 | New compounds |
| PCT/SE1998/001364 WO1999003859A1 (en) | 1997-07-18 | 1998-07-10 | Novel spiroazabicyclic heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9810924A true BR9810924A (pt) | 2000-08-15 |
Family
ID=26663041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9810924-3A BR9810924A (pt) | 1997-07-18 | 1998-07-10 | Composto heterocìclico espiroazabicìclico, composição farmacêutica, uso de um composto, e, processos de tratamento ou profilaxia de doenças humanas ou condições em que a ativação do receptor nicotìnico alfa7 seja benéfica, de distúrbios psicóticos ou distúrbios do enfraquecimento intelectual e do desequilìbrio do ritmo circadiano normal devido a viagens subsÈnicas ou supersÈnicas, da cessação de fumar, do vìcio da nicotina, da dor e da colite ulcerativa e de preparação de um composto |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US6110914A (pt) |
| EP (2) | EP1213291B1 (pt) |
| JP (1) | JP2001510194A (pt) |
| KR (1) | KR100560036B1 (pt) |
| CN (1) | CN1117755C (pt) |
| AR (2) | AR013184A1 (pt) |
| AT (2) | ATE283859T1 (pt) |
| AU (1) | AU739022B2 (pt) |
| BR (1) | BR9810924A (pt) |
| CA (1) | CA2296031C (pt) |
| DE (2) | DE69808631T2 (pt) |
| DK (1) | DK0996622T3 (pt) |
| EE (1) | EE04399B1 (pt) |
| ES (2) | ES2185185T3 (pt) |
| HK (3) | HK1025322A1 (pt) |
| HU (1) | HUP0003844A3 (pt) |
| ID (1) | ID25548A (pt) |
| IL (2) | IL134086A0 (pt) |
| IS (2) | IS2027B (pt) |
| MY (1) | MY116761A (pt) |
| NO (1) | NO325324B1 (pt) |
| NZ (1) | NZ502298A (pt) |
| PL (1) | PL193065B1 (pt) |
| PT (1) | PT996622E (pt) |
| RU (1) | RU2202553C2 (pt) |
| SA (1) | SA98190668B1 (pt) |
| SI (1) | SI0996622T1 (pt) |
| SK (1) | SK283484B6 (pt) |
| TR (1) | TR200000129T2 (pt) |
| TW (1) | TW515799B (pt) |
| WO (1) | WO1999003859A1 (pt) |
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| SE9900100D0 (sv) * | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
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| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
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| CN1294136C (zh) * | 2001-06-01 | 2007-01-10 | 阿斯特拉曾尼卡有限公司 | 用于治疗的烟碱乙酰胆碱受体新型配体 |
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