NO20013921L - Heterocykliske derivater som inhibitorer av faktor Xa - Google Patents

Heterocykliske derivater som inhibitorer av faktor Xa

Info

Publication number
NO20013921L
NO20013921L NO20013921A NO20013921A NO20013921L NO 20013921 L NO20013921 L NO 20013921L NO 20013921 A NO20013921 A NO 20013921A NO 20013921 A NO20013921 A NO 20013921A NO 20013921 L NO20013921 L NO 20013921L
Authority
NO
Norway
Prior art keywords
heterocyclic derivatives
antithrombotic
inhibitors
factor
methods
Prior art date
Application number
NO20013921A
Other languages
English (en)
Other versions
NO20013921D0 (no
Inventor
Peter William Rodney Caulkett
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20013921D0 publication Critical patent/NO20013921D0/no
Publication of NO20013921L publication Critical patent/NO20013921L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det er beskrevet heterocykliske derivater eller farmasøytisk akseptable salter derav med formel (I) hvor: A er en evt substituert 5- eller 6-leddet monocyklisk aromatisk ring inneholdende 1, 2 eller 3 ring heteroatomer valgt fra oksygen, nitrogen og svovel atomer; idet de har antitrombotisk og antikoagulant egenskaper og er følgelig nyttige i fremgangsmåter for behandling av menneske eller dyr. Det er også beskrevet fremgangsmåter for fremstilling av heterocykliske derivater, farmasøytiske preparater inneholdende disse og anvendelse for fremstilling av medikamenter for anvendelse i dannelse av en antitrombotisk eller antikoagulant effekt.
NO20013921A 1999-02-11 2001-08-10 Heterocykliske derivater som inhibitorer av faktor Xa NO20013921L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9902989.4A GB9902989D0 (en) 1999-02-11 1999-02-11 Heterocyclic derivatives
PCT/GB2000/000354 WO2000047573A1 (en) 1999-02-11 2000-02-08 Heterocyclic derivatives as inhibitors of factor xa

Publications (2)

Publication Number Publication Date
NO20013921D0 NO20013921D0 (no) 2001-08-10
NO20013921L true NO20013921L (no) 2001-10-10

Family

ID=10847476

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013921A NO20013921L (no) 1999-02-11 2001-08-10 Heterocykliske derivater som inhibitorer av faktor Xa

Country Status (24)

Country Link
US (1) US6723723B1 (no)
EP (1) EP1150974B1 (no)
JP (1) JP2002536443A (no)
KR (1) KR20010102072A (no)
AT (1) ATE223402T1 (no)
AU (1) AU757738B2 (no)
BR (1) BR0008130A (no)
CA (1) CA2362392A1 (no)
CZ (1) CZ20012867A3 (no)
DE (1) DE60000410T2 (no)
DK (1) DK1150974T3 (no)
ES (1) ES2181637T3 (no)
GB (1) GB9902989D0 (no)
HU (1) HUP0105102A3 (no)
IL (1) IL144792A0 (no)
NO (1) NO20013921L (no)
NZ (1) NZ513350A (no)
PL (1) PL349220A1 (no)
PT (1) PT1150974E (no)
RU (1) RU2226193C2 (no)
SK (1) SK11462001A3 (no)
TR (1) TR200102306T2 (no)
WO (1) WO2000047573A1 (no)
ZA (1) ZA200106337B (no)

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US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
EP1870401A4 (en) * 2005-04-06 2011-06-15 Msd Kk SUBSTITUTE DERIVATIVE PIPERAZINE IN 1,4
JP5214096B2 (ja) * 2005-06-17 2013-06-19 富士フイルムファインケミカルズ株式会社 新規なビピリジン誘導体
US20220380478A1 (en) 2019-07-01 2022-12-01 Tonix Pharma Holdings Limited Anti-cd154 antibodies and uses thereof
EP4274587A1 (en) 2021-01-06 2023-11-15 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

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Also Published As

Publication number Publication date
BR0008130A (pt) 2002-02-05
CA2362392A1 (en) 2000-08-17
ZA200106337B (en) 2002-11-01
DE60000410D1 (de) 2002-10-10
GB9902989D0 (en) 1999-03-31
CZ20012867A3 (cs) 2001-10-17
NZ513350A (en) 2003-01-31
DK1150974T3 (da) 2002-12-02
RU2226193C2 (ru) 2004-03-27
US6723723B1 (en) 2004-04-20
SK11462001A3 (sk) 2001-12-03
HUP0105102A2 (hu) 2002-05-29
EP1150974A1 (en) 2001-11-07
ES2181637T3 (es) 2003-03-01
AU757738B2 (en) 2003-03-06
PL349220A1 (en) 2002-07-01
EP1150974B1 (en) 2002-09-04
DE60000410T2 (de) 2003-06-05
AU2447000A (en) 2000-08-29
HUP0105102A3 (en) 2003-01-28
JP2002536443A (ja) 2002-10-29
PT1150974E (pt) 2003-01-31
NO20013921D0 (no) 2001-08-10
WO2000047573A1 (en) 2000-08-17
KR20010102072A (ko) 2001-11-15
TR200102306T2 (tr) 2001-12-21
IL144792A0 (en) 2002-06-30
ATE223402T1 (de) 2002-09-15

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