DE60000410D1 - Heterocyclische derivate als inhibitoren von faktor xa - Google Patents
Heterocyclische derivate als inhibitoren von faktor xaInfo
- Publication number
- DE60000410D1 DE60000410D1 DE60000410T DE60000410T DE60000410D1 DE 60000410 D1 DE60000410 D1 DE 60000410D1 DE 60000410 T DE60000410 T DE 60000410T DE 60000410 T DE60000410 T DE 60000410T DE 60000410 D1 DE60000410 D1 DE 60000410D1
- Authority
- DE
- Germany
- Prior art keywords
- heterocyclic derivatives
- inhibitors
- factor
- antithrombotic
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9902989.4A GB9902989D0 (en) | 1999-02-11 | 1999-02-11 | Heterocyclic derivatives |
PCT/GB2000/000354 WO2000047573A1 (en) | 1999-02-11 | 2000-02-08 | Heterocyclic derivatives as inhibitors of factor xa |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60000410D1 true DE60000410D1 (de) | 2002-10-10 |
DE60000410T2 DE60000410T2 (de) | 2003-06-05 |
Family
ID=10847476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60000410T Expired - Lifetime DE60000410T2 (de) | 1999-02-11 | 2000-02-08 | Heterocyclische derivate als inhibitoren von faktor xa |
Country Status (24)
Country | Link |
---|---|
US (1) | US6723723B1 (de) |
EP (1) | EP1150974B1 (de) |
JP (1) | JP2002536443A (de) |
KR (1) | KR20010102072A (de) |
AT (1) | ATE223402T1 (de) |
AU (1) | AU757738B2 (de) |
BR (1) | BR0008130A (de) |
CA (1) | CA2362392A1 (de) |
CZ (1) | CZ20012867A3 (de) |
DE (1) | DE60000410T2 (de) |
DK (1) | DK1150974T3 (de) |
ES (1) | ES2181637T3 (de) |
GB (1) | GB9902989D0 (de) |
HU (1) | HUP0105102A3 (de) |
IL (1) | IL144792A0 (de) |
NO (1) | NO20013921L (de) |
NZ (1) | NZ513350A (de) |
PL (1) | PL349220A1 (de) |
PT (1) | PT1150974E (de) |
RU (1) | RU2226193C2 (de) |
SK (1) | SK11462001A3 (de) |
TR (1) | TR200102306T2 (de) |
WO (1) | WO2000047573A1 (de) |
ZA (1) | ZA200106337B (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
AU2006235759B2 (en) * | 2005-04-06 | 2011-07-28 | Msd K.K. | 1,4-substituted piperazine derivative |
JP5214096B2 (ja) * | 2005-06-17 | 2013-06-19 | 富士フイルムファインケミカルズ株式会社 | 新規なビピリジン誘導体 |
JP2022538674A (ja) | 2019-07-01 | 2022-09-05 | トニックス ファーマ リミテッド | 抗cd154抗体およびその使用 |
AU2022205313A1 (en) | 2021-01-06 | 2023-07-20 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT340933B (de) | 1973-08-20 | 1978-01-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze |
US4167567A (en) | 1978-05-05 | 1979-09-11 | The Upjohn Company | Antihypertensive 4-aminoquinolines |
US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
SE8203887D0 (sv) | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | Nya trombininhiberande foreningar |
DE3246932A1 (de) | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
FR2557570B1 (fr) | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US4840963A (en) | 1984-03-14 | 1989-06-20 | Merck & Co., Inc. | 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure |
GB8601160D0 (en) | 1986-01-17 | 1986-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
GB8603120D0 (en) | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
GB8609630D0 (en) | 1986-04-19 | 1986-05-21 | Pfizer Ltd | Anti-arrhythmia agents |
GB8710494D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Antiarrhythmic agents |
JPH0696575B2 (ja) | 1987-09-17 | 1994-11-30 | 三菱化成株式会社 | 4−アミノピリジン誘導体及びその酸付加塩 |
US4871721A (en) | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
GB8817315D0 (en) | 1988-07-20 | 1988-08-24 | Pfizer Ltd | Triazole antifungal agents |
GB8819307D0 (en) | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
DE3905364A1 (de) | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
GB8905526D0 (en) | 1989-03-10 | 1989-04-19 | Fujisawa Pharmaceutical Co | N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same |
IE64358B1 (en) | 1989-07-18 | 1995-07-26 | Ici Plc | Diaryl ether heterocycles |
US5032604A (en) | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
DE3943225A1 (de) | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
CA2073776A1 (en) | 1990-11-15 | 1992-05-16 | Joerg Stuerzebecher | Meta-substituted phenyl alanine derivatives |
EP0495750A3 (en) | 1991-01-14 | 1992-09-16 | Ciba-Geigy Ag | Heterocyclic hydroxylamine |
IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
FR2676054B1 (fr) | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
EP0519449A1 (de) | 1991-06-21 | 1992-12-23 | Boehringer Mannheim Italia S.P.A. | 2-Amino-4-aryl-Thiazolderivate mit asthmahemmender und entzündungshemmender Wirkung auf die Atemwegen |
AU2573592A (en) | 1991-09-19 | 1993-04-27 | Smithkline Beecham Corporation | Pyridine compounds for treating leukotriene-related diseases |
US5541330A (en) | 1991-12-10 | 1996-07-30 | Eastman Kodak Company | Ion-sensitive compounds |
PH31294A (en) | 1992-02-13 | 1998-07-06 | Thomae Gmbh Dr K | Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them. |
HU211995B (en) | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
US5371091A (en) | 1992-08-31 | 1994-12-06 | Bristol-Myers Squibb Company | Heteroaromatic amine thrombin inhibitors |
FR2697252B1 (fr) | 1992-10-28 | 1994-12-09 | Fournier Ind & Sante | Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique. |
DE4243858A1 (de) | 1992-12-23 | 1994-06-30 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5332822A (en) | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
US5364865A (en) | 1992-12-30 | 1994-11-15 | Sterling Winthrop Inc. | Phenoxy- and phenoxyalkyl-piperidines as antiviral agents |
DE4302485A1 (de) | 1993-01-29 | 1994-08-04 | Merck Patent Gmbh | Piperazinderivate |
AU5878194A (en) | 1993-02-10 | 1994-08-29 | Pentapharm Ag | Piperazides of substituted phenylalanine derivates as thrombin inhibitors |
TW257757B (de) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
DE4306506A1 (de) | 1993-03-03 | 1994-09-08 | Boehringer Mannheim Gmbh | Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
DE4306873A1 (de) | 1993-03-05 | 1994-09-08 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridine-Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
AU692439B2 (en) | 1993-03-29 | 1998-06-11 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
ATE202345T1 (de) | 1993-03-29 | 2001-07-15 | Astrazeneca Ab | Heterozyklische derivate als plätchenaggregationsinhibitoren |
US5681954A (en) | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
WO1996005189A1 (de) | 1994-08-09 | 1996-02-22 | Pentapharm Ag | Neue inhibitoren vom benzamidintyp |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
JPH10511357A (ja) | 1994-12-22 | 1998-11-04 | スミスクライン・ビーチャム・コーポレイション | フィブリノゲン受容体拮抗物質 |
US6037343A (en) | 1994-12-22 | 2000-03-14 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
US5856326A (en) | 1995-03-29 | 1999-01-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IT1282797B1 (it) | 1995-04-21 | 1998-03-31 | Colla Paolo | Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids |
GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
GB9602294D0 (en) | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
EP0892780B1 (de) | 1996-02-22 | 2002-11-20 | Bristol-Myers Squibb Pharma Company | M-amidinophenyl-analoga als faktor-xa-inhibitoren |
CA2260872A1 (en) | 1996-08-14 | 1998-02-19 | Elaine Sophie Elizabeth Stokes | Substituted pyrimidine derivatives and their pharmaceutical use |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
EP0966460A1 (de) | 1997-02-13 | 1999-12-29 | Zeneca Limited | Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren verwendung finden |
AU5999798A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
GB9715892D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
GB9715894D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
US6753331B1 (en) | 1998-05-02 | 2004-06-22 | Astrazeneca Ab | Heterocyclic derivatives which inhibit factor Xa |
GB9809349D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
-
1999
- 1999-02-11 GB GBGB9902989.4A patent/GB9902989D0/en not_active Ceased
-
2000
- 2000-02-08 EP EP00902725A patent/EP1150974B1/de not_active Expired - Lifetime
- 2000-02-08 WO PCT/GB2000/000354 patent/WO2000047573A1/en not_active Application Discontinuation
- 2000-02-08 RU RU2001124855/04A patent/RU2226193C2/ru not_active IP Right Cessation
- 2000-02-08 HU HU0105102A patent/HUP0105102A3/hu unknown
- 2000-02-08 JP JP2000598493A patent/JP2002536443A/ja active Pending
- 2000-02-08 IL IL14479200A patent/IL144792A0/xx unknown
- 2000-02-08 SK SK1146-2001A patent/SK11462001A3/sk unknown
- 2000-02-08 PL PL00349220A patent/PL349220A1/xx not_active Application Discontinuation
- 2000-02-08 DE DE60000410T patent/DE60000410T2/de not_active Expired - Lifetime
- 2000-02-08 AT AT00902725T patent/ATE223402T1/de active
- 2000-02-08 CA CA002362392A patent/CA2362392A1/en not_active Abandoned
- 2000-02-08 ES ES00902725T patent/ES2181637T3/es not_active Expired - Lifetime
- 2000-02-08 CZ CZ20012867A patent/CZ20012867A3/cs unknown
- 2000-02-08 BR BR0008130-2A patent/BR0008130A/pt not_active IP Right Cessation
- 2000-02-08 DK DK00902725T patent/DK1150974T3/da active
- 2000-02-08 KR KR1020017010184A patent/KR20010102072A/ko not_active Application Discontinuation
- 2000-02-08 TR TR2001/02306T patent/TR200102306T2/xx unknown
- 2000-02-08 PT PT00902725T patent/PT1150974E/pt unknown
- 2000-02-08 AU AU24470/00A patent/AU757738B2/en not_active Ceased
- 2000-02-08 NZ NZ513350A patent/NZ513350A/xx unknown
- 2000-02-08 US US09/913,071 patent/US6723723B1/en not_active Expired - Fee Related
-
2001
- 2001-08-01 ZA ZA200106337A patent/ZA200106337B/en unknown
- 2001-08-10 NO NO20013921A patent/NO20013921L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6723723B1 (en) | 2004-04-20 |
DE60000410T2 (de) | 2003-06-05 |
BR0008130A (pt) | 2002-02-05 |
HUP0105102A2 (hu) | 2002-05-29 |
ZA200106337B (en) | 2002-11-01 |
PT1150974E (pt) | 2003-01-31 |
NZ513350A (en) | 2003-01-31 |
RU2226193C2 (ru) | 2004-03-27 |
AU757738B2 (en) | 2003-03-06 |
HUP0105102A3 (en) | 2003-01-28 |
IL144792A0 (en) | 2002-06-30 |
EP1150974B1 (de) | 2002-09-04 |
NO20013921L (no) | 2001-10-10 |
CA2362392A1 (en) | 2000-08-17 |
CZ20012867A3 (cs) | 2001-10-17 |
AU2447000A (en) | 2000-08-29 |
GB9902989D0 (en) | 1999-03-31 |
SK11462001A3 (sk) | 2001-12-03 |
KR20010102072A (ko) | 2001-11-15 |
ATE223402T1 (de) | 2002-09-15 |
PL349220A1 (en) | 2002-07-01 |
JP2002536443A (ja) | 2002-10-29 |
NO20013921D0 (no) | 2001-08-10 |
TR200102306T2 (tr) | 2001-12-21 |
ES2181637T3 (es) | 2003-03-01 |
DK1150974T3 (da) | 2002-12-02 |
EP1150974A1 (de) | 2001-11-07 |
WO2000047573A1 (en) | 2000-08-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |