CN100402515C - 用作抗惊厥药的取代2-苯并[c]呋喃酮 - Google Patents
用作抗惊厥药的取代2-苯并[c]呋喃酮 Download PDFInfo
- Publication number
- CN100402515C CN100402515C CNB018120687A CN01812068A CN100402515C CN 100402515 C CN100402515 C CN 100402515C CN B018120687 A CNB018120687 A CN B018120687A CN 01812068 A CN01812068 A CN 01812068A CN 100402515 C CN100402515 C CN 100402515C
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- furanone
- benzo
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (19)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB001193295A CN1182127C (zh) | 2000-06-28 | 2000-06-28 | 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物 |
CN00119329.5 | 2000-06-28 | ||
PCT/IB2001/001535 WO2002000638A2 (en) | 2000-06-28 | 2001-06-27 | Substituted phthalides as anti-convulsive drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1440398A CN1440398A (zh) | 2003-09-03 |
CN100402515C true CN100402515C (zh) | 2008-07-16 |
Family
ID=4587601
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB001193295A Expired - Fee Related CN1182127C (zh) | 2000-06-28 | 2000-06-28 | 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物 |
CNB018120687A Expired - Fee Related CN100402515C (zh) | 2000-06-28 | 2001-06-27 | 用作抗惊厥药的取代2-苯并[c]呋喃酮 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB001193295A Expired - Fee Related CN1182127C (zh) | 2000-06-28 | 2000-06-28 | 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物 |
Country Status (19)
Country | Link |
---|---|
US (1) | US6689808B2 (zh) |
EP (1) | EP1320528A2 (zh) |
JP (1) | JP2004501909A (zh) |
KR (1) | KR20030024710A (zh) |
CN (2) | CN1182127C (zh) |
AR (1) | AR030239A1 (zh) |
AU (1) | AU2001280004A1 (zh) |
BR (1) | BR0112043A (zh) |
CA (1) | CA2413752A1 (zh) |
CZ (1) | CZ2003245A3 (zh) |
EA (1) | EA200300044A1 (zh) |
HU (1) | HUP0301567A3 (zh) |
MX (1) | MXPA02012569A (zh) |
NO (1) | NO20026154L (zh) |
NZ (1) | NZ523174A (zh) |
PL (1) | PL359373A1 (zh) |
SK (1) | SK1062003A3 (zh) |
WO (1) | WO2002000638A2 (zh) |
ZA (1) | ZA200210004B (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070082947A1 (en) * | 2003-05-14 | 2007-04-12 | D Orazio Daniel | Use of phthalide derivatives for the treatment and prevention of diabetes mellitus |
KR20060121887A (ko) | 2003-09-23 | 2006-11-29 | 디에스엠 아이피 어셋츠 비.브이. | 진성 당뇨병의 치료 및 예방용 조성물 |
CN1605336A (zh) | 2003-10-10 | 2005-04-13 | 中国医学科学院药物研究所 | 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用 |
EP1757286B1 (en) * | 2004-06-18 | 2017-09-06 | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthalide in preventing and treating alzheimer's disease |
CN106074497A (zh) * | 2010-01-13 | 2016-11-09 | 石药集团恩必普药业有限公司 | 丁苯酞及其衍生物在制备治疗帕金森病的药物中的应用 |
CN102260233A (zh) * | 2011-05-04 | 2011-11-30 | 武汉科技大学 | 3-丁基-1(3h)-异苯并呋喃酮衍生物及其制备方法 |
CN105367526B (zh) * | 2015-10-14 | 2017-07-28 | 济南诚汇双达化工有限公司 | 一种高纯度正丁基苯酞的制备方法 |
CN108727352B (zh) * | 2017-04-14 | 2021-04-23 | 四川大学 | 一类哌啶烷氨甲酰基苯酞类化合物、其制备方法和用途 |
WO2019179346A1 (zh) * | 2018-03-19 | 2019-09-26 | 河南真实生物科技有限公司 | 苯甲酸类化合物及其制备方法和应用 |
CN108752300B (zh) * | 2018-05-16 | 2022-03-25 | 中国科学院昆明植物研究所 | 苄烯叉苯肽类化合物及其药物组合物和其应用 |
CN109111415B (zh) * | 2018-10-25 | 2022-08-23 | 安徽中医药大学 | 一类石斛生物碱衍生物、制备方法和医药用途 |
CN112010827A (zh) * | 2019-05-28 | 2020-12-01 | 四川大学 | 一类苄胺基苯酞类化合物、其制备方法和用途 |
CN112010837B (zh) * | 2019-05-28 | 2021-12-17 | 四川大学 | 一类吡啶甲胺基苯酞类化合物、其制备方法和用途 |
CN110452203B (zh) * | 2019-08-29 | 2021-04-13 | 忻州师范学院 | 一种1-氧代-1,3-二氢-3-羟基苯并呋喃-5-甲酸的制备方法 |
CN112794831B (zh) * | 2021-04-06 | 2021-07-27 | 北京理工大学 | 3-(3′-羟基丁基)异苯并呋喃-1(3h)-酮衍生物及其组合物、制备方法和用途 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0151964A2 (en) * | 1984-02-02 | 1985-08-21 | Laboratorio Farmaceutico C.T. s.r.l. | New derivatives of alpha-amino-gamma-butyrolactone, method for the preparation thereof and pharmaceutical compositions containing them |
US4855320A (en) * | 1986-05-05 | 1989-08-08 | Dr. Willmar Schwabe Gmbh & Company | 5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them |
EP0341081A2 (en) * | 1988-05-06 | 1989-11-08 | Ono Pharmaceutical Co., Ltd. | Novel amino acid derivatives |
CN1106032A (zh) * | 1993-09-17 | 1995-08-02 | 希巴-盖吉股份公司 | 苯并呋喃-2-酮用作稳定剂 |
CN1210564A (zh) * | 1996-05-10 | 1999-03-10 | 巴斯福股份公司 | 2-苯并[c]呋喃酮类化合物的制备方法 |
CN1216987A (zh) * | 1996-07-03 | 1999-05-19 | 巴斯福股份公司 | 2-苯并[c]呋喃酮的制备方法 |
-
2000
- 2000-06-28 CN CNB001193295A patent/CN1182127C/zh not_active Expired - Fee Related
-
2001
- 2001-06-27 SK SK106-2003A patent/SK1062003A3/sk unknown
- 2001-06-27 KR KR1020027017839A patent/KR20030024710A/ko not_active Application Discontinuation
- 2001-06-27 CZ CZ2003245A patent/CZ2003245A3/cs unknown
- 2001-06-27 WO PCT/IB2001/001535 patent/WO2002000638A2/en not_active Application Discontinuation
- 2001-06-27 MX MXPA02012569A patent/MXPA02012569A/es unknown
- 2001-06-27 NZ NZ523174A patent/NZ523174A/en unknown
- 2001-06-27 US US10/312,650 patent/US6689808B2/en not_active Expired - Fee Related
- 2001-06-27 CN CNB018120687A patent/CN100402515C/zh not_active Expired - Fee Related
- 2001-06-27 EA EA200300044A patent/EA200300044A1/ru unknown
- 2001-06-27 JP JP2002505386A patent/JP2004501909A/ja active Pending
- 2001-06-27 BR BR0112043-3A patent/BR0112043A/pt not_active IP Right Cessation
- 2001-06-27 HU HU0301567A patent/HUP0301567A3/hu unknown
- 2001-06-27 EP EP01958282A patent/EP1320528A2/en not_active Withdrawn
- 2001-06-27 PL PL01359373A patent/PL359373A1/xx not_active Application Discontinuation
- 2001-06-27 AR ARP010103051A patent/AR030239A1/es not_active Application Discontinuation
- 2001-06-27 CA CA002413752A patent/CA2413752A1/en not_active Abandoned
- 2001-06-27 AU AU2001280004A patent/AU2001280004A1/en not_active Abandoned
-
2002
- 2002-12-10 ZA ZA200210004A patent/ZA200210004B/en unknown
- 2002-12-20 NO NO20026154A patent/NO20026154L/no not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0151964A2 (en) * | 1984-02-02 | 1985-08-21 | Laboratorio Farmaceutico C.T. s.r.l. | New derivatives of alpha-amino-gamma-butyrolactone, method for the preparation thereof and pharmaceutical compositions containing them |
US4855320A (en) * | 1986-05-05 | 1989-08-08 | Dr. Willmar Schwabe Gmbh & Company | 5-arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and processes for the preparation thereof and medicaments containing them |
EP0341081A2 (en) * | 1988-05-06 | 1989-11-08 | Ono Pharmaceutical Co., Ltd. | Novel amino acid derivatives |
CN1106032A (zh) * | 1993-09-17 | 1995-08-02 | 希巴-盖吉股份公司 | 苯并呋喃-2-酮用作稳定剂 |
CN1210564A (zh) * | 1996-05-10 | 1999-03-10 | 巴斯福股份公司 | 2-苯并[c]呋喃酮类化合物的制备方法 |
CN1216987A (zh) * | 1996-07-03 | 1999-05-19 | 巴斯福股份公司 | 2-苯并[c]呋喃酮的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
US20030220393A1 (en) | 2003-11-27 |
MXPA02012569A (es) | 2004-05-17 |
CN1440398A (zh) | 2003-09-03 |
US6689808B2 (en) | 2004-02-10 |
BR0112043A (pt) | 2003-10-28 |
AU2001280004A1 (en) | 2002-01-08 |
EA200300044A1 (ru) | 2003-06-26 |
CA2413752A1 (en) | 2002-01-03 |
AR030239A1 (es) | 2003-08-13 |
SK1062003A3 (en) | 2003-05-02 |
JP2004501909A (ja) | 2004-01-22 |
HUP0301567A3 (en) | 2005-08-29 |
WO2002000638A3 (en) | 2002-05-23 |
HUP0301567A2 (hu) | 2003-09-29 |
KR20030024710A (ko) | 2003-03-26 |
CZ2003245A3 (cs) | 2003-05-14 |
NO20026154D0 (no) | 2002-12-20 |
ZA200210004B (en) | 2003-12-10 |
NZ523174A (en) | 2004-06-25 |
CN1330069A (zh) | 2002-01-09 |
CN1182127C (zh) | 2004-12-29 |
PL359373A1 (en) | 2004-08-23 |
WO2002000638A2 (en) | 2002-01-03 |
WO2002000638A8 (en) | 2003-08-28 |
NO20026154L (no) | 2003-02-20 |
EP1320528A2 (en) | 2003-06-25 |
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